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Biomedical subjects

J F Jovanovich

Publications and source records attributed to J F Jovanovich.

5 recordsLinked to original sources
PubMed1983

The risk of hepatitis B among select employee groups in an urban hospital.

Hospital employees are at various degrees of risk for development of hepatitis B infections. A retrospective review of surveillance records in five clinical areas at high risk for hepatitis B exposure was carried out to determine its prevalence and incidence in each area. The area surveyed with the highest risk was the emergency department. It was followed, in descending order, by the operating room, the medical and surgical intensive care units, and the dentistry-oral surgery clinic. The surveyed area at the lowest risk was the hemodialysis unit. Strict infection-control guidelines probably minimize the employees' risk to hepatitis in the hemodialysis unit. In the emergency department, however, employees may be increasingly exposed to hepatitis B by dealing with life-threatening problems in an uncontrolled setting.

Dentistry↗
PubMed1983

Cephapirin therapy in infective endocarditis.

Ten patients, eight of them heroin addicts, with infective endocarditis were treated with cephapirin. Causative organisms included Staphylococcus aureus in six patients and viridans streptococci, S bovis, and S pneumoniae in one patient each. In one of the patients with endocarditis, both S aureus and an organism of the beta-Streptococcus group were simultaneously isolated. All patients except two, both with monomicrobial S aureus endocarditis, were cured. All isolates were inhibited by less than or equal to 0.5 micrograms/ml of cephapirin. Peak serum bactericidal activity greater than or equal to 32 times the minimal inhibitory concentration (MIC) of the causative organism was achieved in all cases after giving 2 gm IV every four hours. After using large inoculums of staphylococci for in vitro tests, we found that twofold to eightfold increases in MIC occurred. Cephapirin was well tolerated intravenously and high levels in serum were achieved without toxicity or accumulation of the drug.

Adult↗
PubMed1981

Failure of probenecid to alter the pharmacokinetics of ceforanide.

This investigation evaluated the effect of probenecid on ceforanide concentrations in eight healthy volunteers. Each volunteer was given 1 or 2 g of ceforanide either alone or with 1 g of probenecid. Concentrations of ceforanide in plasma, urine, and saliva were then measured. Probenecid did not alter the plasma concentrations of ceforanide, nor did it affect the urinary excretion of this agent. Ceforanide was not secreted into saliva in any detectable amount either when administered alone or with probenecid. It is not clear why probenecid has a negligible effect on ceforanide concentrations in plasma. It may be that tubular secretion plays less of a role in the excretion of ceforanide than expected, or that the physical properties of ceforanide prevent probenecid from affecting its excretion.

Adult↗