PubMed Health⌕ Search

Biomedical subjects

J F Kennedy

Publications and source records attributed to J F Kennedy.

At least 109 records · Page 6Linked to original sources
PubMed1973

Poly(N-acryloyl-4- and -5-aminosalicylic acids. II. Antibacterial properties and uses for the preparation of active, insoluble antibiotics.

The antibacterial properties of poly(N-acryloyl-4- and -5-aminosalicylic acids) and their borate complexes were evaluated. Poly(N-acryloyl-4- and 5-aminosalicylic acids) were used to render the antibiotics streptomycin and gentamicin insoluble. The antibacterial properties of the resultant water-insoluble streptomycin and gentamicin derivatives were evaluated, and the results show that the polymers are suited to the preparation of active insoluble antibiotics. Potential antimicrobial applications of the polymers are discussed.

Acrylates↗
PubMed1973

Active insolubilized antibiotics based on cellulose and cellulose carbonate.

The coupling of a number of antibiotics to cellulose and cellulose trans-2,3-carbonate under a series of coupling conditions has been investigated, and it has been shown that by such couplings active insoluble derivatives of antibiotics can be produced. It was found that the antibiotics became firmly bound to cellulose itself, whereas use of cellulose carbonate extended the range of antibacterial activity retained. In the case of cellulose, it was considered that physical adsorption phenomena were operating, whereas a covalent bond was more likely in the case of cellulose carbonate where the antibiotic amino groups could attack the electrophilic cyclic carbonate carbon atoms. The release of antibiotic from the matrix during testing of antibacterial activity was likely due to the action of a cellulase or additionally an esterase in the case of cellulose carbonate. The importance and potential of these new types of chemical derivatives are discussed in terms of new outlets for the commerical use of cellulose.

Anti-Bacterial Agents↗
PubMed1972

Structural investigation of the carbohydrate element of human pituitary follicle-stimulating hormone by methylation analysis.

A preparation of human follicle-stimulating hormone has been subjected to methylation analysis by using the methyl sulphinyl carbanion-dimethyl sulphoxide-methyl iodide method. The hydrolysis products of the methylated glycoprotein were reduced, acetylated, analysed by gas-phase chromatography and mass spectrometry and identified by comparison with standards. Methylation analysis demonstrated that (1) the d-galactose, mannose, fucose and 2-amino-2-deoxyglucose units exist in the pyranose forms, (2) the 2-amino-2-deoxyglucose units are N-acetylated, (3) the fucopyranose units occupy terminal non-reducing positions, (4) the d-galactopyranose units are linked in the 1- and 2-positions, (5) the mannopyranose units exist in three forms, some as terminal non-reducing residues, some as 1,6-linked residues and some as 1,3,4-linked branch points, and (6) the 2-acetamido deoxyglucopyranose units are 1,6-linked. These structural assignments are compared with other data previously obtained for the carbohydrate moieties of follicle-stimulating hormone.

Acetylation↗
PubMed1970

Isolation and analysis of the nucleic acids and polysaccharides from Clostridium welchii.

A method previously described for the use of bentonite in the isolation of the nucleic acids from two gram-positive organisms was applied to the isolation of the nucleic acids from two strains of Clostridium welchii. The nucleic acids were separated from polysaccharides by the fractional precipitation of their cetyltrimethyl-ammonium salts from sodium chloride solution, and the base composition of the nucleic acids was determined. One strain of C. welchii investigated (NCTC 10578) was shown to produce considerable quantities of an acidic and also a weakly acidic or neutral polysaccharide; the other strain (ATCC 10543) gave very small quantities of the latter but none of the former polysaccharide. The monosaccharide composition of these polysaccharides was determined and the acidic polysaccharide was shown to resemble dermatan sulfate.

Aluminum Silicates↗