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J F Kreul

Publications and source records attributed to J F Kreul.

7 recordsLinked to original sources
PubMed1990

Doxacurium and mivacurium do not trigger malignant hyperthermia in susceptible swine.

The role of succinylcholine in the precipitation of malignant hyperthermia (MH) necessitates the testing of new neuromuscular relaxants for their ability to trigger MH in MH-susceptible swine before general human use. We tested doxacurium and mivacurium, two new nondepolarizing bis-benzylisoquinolinium neuromuscular relaxants, at ED95 and at four times ED95 doses in swine previously documented to be MH-susceptible. In none of the 16 animals was MH triggered after administration of these relaxants, whereas all animals developed fatal MH after administration of halothane or halothane plus succinylcholine. Muscle biopsy specimens taken before administration of the relaxant confirmed that all animals had increased sensitivity to halothane, caffeine, or both. Thus, we conclude that doxacurium and mivacurium are not triggering agents of malignant hyperthermia in MH-susceptible swine.

Animals↗
PubMed1979

Heat stroke.

Explore the source record for details and available documents.

Body Temperature↗
PubMed1977

A comparison of central venous pressure and pleural pressure in supine dogs.

Respiration induced changes in central venous pressure were analyzed and compared with intrapleural pressure changes in dogs. During normal breathing intrapleural pressure changes were transmitted to the vena cava with distortion consisting of attenuation, addition of cardiac and mean pressure components, and a slight temporal delay. Attenuation and temporal delay increased in a regular manner as mean central venous pressure increased. Cardiac components could be removed by electronic filters. The presence of these distortions suggest the need for caution in interpreting intrapleural pressure changes from central venous pressure.

Animals↗
PubMedDate not supplied

Patient monitoring in the operating room--an anesthetist's viewpoint.

The spectrum of patient monitoring techniques and equipment presently available in the operating room is reviewed from the anesthetist's viewpoint. Although electronic monitoring instruments are becoming more sophisticated with self-contained microprocessors or computer interfaces, few are designed for performance specifically within the hostile environment of the operating room. Intraoperative patient monitoring equipment lacks interchangeable transducers, facilities for automatic collection of physiological data, and methods for the display of trends in the patient's condition. Event recording during anesthesia depends upon the time-honored but inefficient handmade record of the anesthetist. Within the context of developing a computer-assisted monitoring and display system, this commentary presents the physician's perspective of instrumentation limitation and successes.

Anesthesiology↗