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Biomedical subjects

J F Mahony

Publications and source records attributed to J F Mahony.

At least 73 records · Page 4Linked to original sources
PubMed1976

Renal transplantation. Effect on the ischemic heart disease of essential malignant hypertension.

In 14 of 204 consecutive cadaveric renal allograft recipients, the primary diagnosis was essential hypertension. Four patients had manifest ischemic heart disease before transplantation. Three of these patients died within 31 months of transplantation from recurrent myocardial infarction, and the fourth experienced coronary insufficiency. Cadaveric renal transplantation does not prevent the progression of coronary artery disease in patients whose renal failure was due to essential hypertension. In the presence of angina or previous myocardial infarction, these patiemts may be better treated by maintenance hemodialysis.

Adult↗
PubMed1976

Clinical evaluation of a dialysate regeneration system for maintenance haemodialysis.

A commercially available sorbent-based dialysate regeneration system has been compared to conventional single-pass dialysate delivery systems for treatment periods of six weeks in 13 patients on maintenance dialysis. The results of treatment were virtually identical in comparing sorbent and conventional systems except that seven of the eight patients using 2-5 M2 dialysers for 3--4 hours thrice per week developed asymptomatic metabolic acidosis with the dialysate regeneration system. This complication was not seen in the five patients using 1-3 M2 dialysers and having a 6--7 hour treatment thrice weekly. Dialysate regeneration systems are particularly suited for use when water supplies are limited or of insufficient purity for single-pass dialysis, and when a portable artificial kidney is required. To avoid metabolic acidosis with this system, using currently available disposable cartridges, each dialysis treatment should be of at least 4-5 hours duration.

Acidosis↗
PubMed1975

Serum doxycycline levels after intravenous administration in haemodialysis patients.

Serum doxycycline levels were measured after intravenous administration of doxycycline to three patients receiving regular haemodialysis therapy. Drug levels were predictable, fell within the therapeutic range, and remained so throughout dialysis. Doxycycline did not accumulate and may be used safely in these patients. A dosage regimen is recommended for maintenance dialysis patients.

Adult↗
PubMed1975

Hyperparathyroidism after renal transplantation.

Renal transplantation reduced circulating parathyroid hormone in recipients of renal allografts. Nevertheless, biochemical and histological evidence of mild hyperparathyroidism persisted up to eight years after renal transplantation despite good graft function.

Bone and Bones↗
PubMed1975

Diseases causing end-stage renal failure in New South Wales.

The nature of the original renal disease was determined in 403 consecutive cases of end-stage renal failure, in 317 of which the clinical diagnosis was corroborated by histological examination of the kidney. Five diseases accounted for 20 or more cases--glomerulonephritis (31% of the total), analgesic nephropathy (29%), primary vesicoureteral reflux (8%), essential hypertension (6%), and polycystic kidneys (5%). In only four cases did renal failure result from chronic pyelonephritis without a demonstrable primary cause. Greater use of micturating cystography and cystoscopy and routine urine testing for salicylate are advocated for earlier diagnosis of the major causes of "pyelonephritis". The incidence of end-stage renal failure in people aged 15-55 in New South Wales was estimated to be at least 34 new cases per million of total population each year.

Acetaminophen↗
PubMed1975

Cold agglutinin formation in patients undergoing haemodialysis. A possible relationship to dialyser re-use.

Cold agglutinins with anti-N characteristics were shown to develop in as short a time as four months in patients on home dialysis. It appeared that the development of such antibodies is related to dialyser re-use. Those who were treated without re-using their dialyser did not develop these antibodies. Anti-N may cause early graft failure associated with agglutination in a cold allograft. Moreover, if these antibodies develop in patients on dialysis there may be problems with extracorporeal dialysis and blood transfusion.

Agglutinins↗
PubMed1975

[Ascites in patients under chronic hemodialysis].

In this collaborative study 9 cases of intractable ascites in chronic hemodialysis patients are evaluated. Six patients died within 14, two more within 18 months after onset of ascites. Possible causes of the pathogenesis (repeated fluid overload, hydrostatic and oncotic pressure flux forces, alteration of membrane permeability) are discussed. Renal homograft transplantation seems to be the only successful treatment.

Adult↗
PubMed1974

Deaths from occlusive arterial disease in renal allograft recipients.

In a series of 325 recipients of cadaveric renal transplants sudden occlusive arterial disease was found to be responsible for 12% of deaths. Acute myocardial infarction (9%) occurred 25 times more than expected in the normal population and cerebral thrombosis (3%) 300 times more. The greatest loss was in the initial three-month period after transplantation. Patients with renal failure due to essential hypertension were especially at risk, accounting for six of the 12 deaths.

Adult↗