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Biomedical subjects

J F Marquet

Publications and source records attributed to J F Marquet.

At least 19 recordsLinked to original sources

Psychoacoustical tuning curves. Normative data for clinical use.

This normative study presents a clinically applicable method with which to obtain Psychoacoustical Tuning Curves: data are obtained with clinical audiometers, and measurements are performed on normal-hearing non-trained volunteers. A simultaneous masking method with test frequency of 4,000 Hz was used, withmasking being incremented in 5 dB or 1 dB steps. One group of subjects was tested three times with 5 dB incrementing steps to evaluate the method's reproducibility. A second group of subjects was measured twice with 1 dB incrementing steps, to compare the reproducibility of the 1-dB step measurements, and the difference between the 1-dB step and 5-dB step measurements. All the data were evaluated as normative values. The method presented proves to have a good reproducibility. Although testing with 1-dB incrementing steps provides more accurate measurements and curves with steeper slopes, the 5-dB incrementing step method is more practicable. Interest variability evaluation indicates that differences between two measurements performed on the same person exceeding 120 Hz (2 SD) bandwidth can be interpreted as significant.

Acoustic Stimulation↗

Effect of isepamicin dosing scheme on concentration in cochlear tissue.

To investigate the possible effect of the dosing scheme of aminoglycosides on their concentration in the cochlear tissue, we gave two groups of 12 guinea pigs subcutaneous doses of 45 mg of isepamicin (ca. 30 mg of active product) per kg of body weight daily for eight consecutive days. The first group received the drug by continuous infusion, while the second group received it by single daily injection. On the final day of administration, the animals were sacrificed and the cochlear tissue was removed. The tissues from the cochleas of pairs of guinea pigs were pooled. The isepamicin concentrations in the cochlear duct tissue (organ of Corti plus lateral wall) and the cochlear nerve tissue were determined separately. Hearing levels before and after treatment were assessed by means of frequency-specific auditory brain stem responses (ABR). The creatinine level in serum was determined on the last day of the administration. None of the animals in either group showed signs of renal insufficiency or of hearing impairment. The median isepamicin concentration in the cochlear duct was 2.40 micrograms/mg of protein after continuous administration and 2.50 micrograms/mg of protein after once-daily administration, compared with the concentration in the cochlear nerve, where it was 1.93 micrograms/mg of protein after continuous administration and 2.59 micrograms/mg of protein after once-daily administration. These differences are statistically insignificant. The results give evidence for linear uptake kinetics of isepamicin in the inner ear tissue and may be directly relevant to the clinical dosing of the drug.

Animals↗

The solitary schwannoma of the eighth cranial nerve. An immunohistochemical study of the cochlear nerve-tumor interface.

Given recent controversy concerning hearing preservation surgery of the acoustic neurinoma, an immunohistochemical study was undertaken to investigate the cochlear nerve-tumor interface. Ten intact medium-sized acoustic neurinomas were studied by means of classic staining procedures and an immunohistochemical technique using monoclonal mouse antibodies to human neurofilaments. Our observations indicate that the cochlear nerve is histologically involved in the tumoral process in those cases in which macroscopically visible adherences between the cochlear nerve and the tumor are present. We were not able to discern a clear cleavage plane. Six of the 10 specimens showed tumoral invasion of the cochlear nerve. Several therapeutic attitudes are discussed in view of these observations and reports from the international literature. In conclusion, the principle of hearing preservation surgery is rejected in favor of total tumor removal in every case in which surgery is indicated.

Aged↗

A pharyngeal hairy polyp causing neonatal airway obstruction: a case study.

A case of neonatal respiratory distress due to an oropharyngeal hairy polyp is reported with its MRI assessment. The place of hairy polyps in the differential diagnosis of upper respiratory tract obstruction is discussed. Early and rapid diagnosis and treatment may be lifesaving for the newborn.

Airway Obstruction↗

[The Audiant Bone Conductor. Clinical experience in 2 patients].

In this paper we present you our clinical experience of 2 cases in which we implanted the Audiant Bone Conductor (by J. Hough). Our conclusion is that we should be very careful in making the decision to do such an implant; indications and limitations should be known by every surgeon who intends to do an implant.

Audiometry, Speech↗

The UIA-KUL cochlear implant. Goals and status praesens.

The authors describe the characteristics and specific advantages of their 8 channel bipolar intrascalar stimulator, its main asset being flexibility. They emphasize the need for caution in the use of cochlear implants in children.

Adult↗

[Homograft tympanic membrane and ossicular chain (author's transl)].

Ten years study of the use of homografts in reconstructive surgery of the ear have enabled the author to achieve excellent results, from both a functional as well as anatomical standpoint. At present, restoration of auditory function is almost always possible. The viability of homografts of the tympanic membrane, the annulus, tendons, ligaments and periosteum seems to pose no problem but revitalisation of the ossicles is less certain. A description is given of the different methods used for the removal of transplant material, its fixation, selection and conservation.

Chronic Disease↗

Neurofibroma of the vagus nerve in the head and neck: a case report.

A case of a tumor of the vagus nerve, showing typical features of a neurofibroma, is presented. The natural history is reviewed, and several technical investigations, with particular reference to the contributions of magnetic resonance imaging and immunohistochemical techniques in the differential diagnosis, are discussed.

Adult↗