Metabolism of palmitaldehyde-1-14C in the rat brain.
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Biomedical subjects
Publications and source records attributed to J F Mead.
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The muscle of Latimeria chalumnae contains 30 to 71 percent (dry weight) of lipid deposited extracellularly. Wax esters constituted 90 percent or more of the lipids from muscle and fat storage tissues. These esters, by gaschromatographic analysis, consisted of C(30) to C(40) homologs with one or two double bonds.
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An enzyme system consisting of washed acetone powder of pig brain, adenosine triphosphate, nicotinamide adenine dinucleotide, magnesium, fumaric acid, and ascorbic acid was found to catalyze the oxidative decarboxylation of 2-ketostearic acid. The products were carbon dioxide and heptadecanoic acid. Washing the enzyme powder with ethylene-diaminetetraacetate and other chelating agents destroyed the activity. Further properties of the enzyme system are described. It is believed that this enzyme system accounts in part for the 1-carbon degradation route for brain fatty acids.
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