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Biomedical subjects

J F Munro

Publications and source records attributed to J F Munro.

At least 91 records · Page 5Linked to original sources
PubMed1970

Further experience with prolon- ged therapeutic starvation in gross refractory obesity.

Twenty-five patients suffering from gross refractory obesity agreed to be starved in hospital until they weighed not more than 25% over their ideal weight. Two discharged themselves prematurely, four defaulted from follow-up, and seven who for various reasons were discharged before completing their treatment have since regained weight. After a mean follow-up period of nearly 18 months 8 of the remaining 12 remained near their weight on discharge. Some kind of initial psychological assessment might improve these results, but prolonged therapeutic starvation may be of value in young patients with gross refractory obesity who are psychologically suitable and socially able to undergo such treatment.

Adolescent↗
PubMed1969

Weight-reducing effect of diguanides in obese non-diabetic women.

A double-blind trial was carried out to assess the weight-reducing effect of the diguanides in 90 women with refractory obesity and normal oral glucose tolerance. The daily dosage of phenformin and metformin was increased at weekly intervals up to 300 mg. and 3 g. respectively, and patients were maintained at this dose or on the maximum they could tolerate without anorexia or other gastrointestinal side-effects. Seventy-seven completed the 16-week period of study. There was a statistically significant difference between the mean weight change of the control and the treated groups, but no difference between those treated by phenformin or metformin. The weight-losing influence of the diguanides appeared to be no longer significant after the twelfth week of treatment.

Adult↗