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J F Newcombe

Publications and source records attributed to J F Newcombe.

16 recordsLinked to original sources
PubMed1987

Axillary artery thrombosis: a complication of axillo-femoral bypass grafts.

We report three cases of late axillary artery thrombosis after axillofemoral bypass grafting. In each patient the artery was found to have been pulled down by the graft and angulated sharply. This is an important complication, which resulted in the loss of a limb in one patient. It is recommended that the upper anastomosis must be explored without delay. Anticoagulation or attempts to clear the thrombus with the more distal branchial artery approach are unlikely to be successful and serve only to delay definitive management.

Aged↗
PubMed1969

Antagonism of the response of human isolated arteries to noradrenaline.

1. Spirally-cut strips from human visceral arteries isolated in vitro were contracted by noradrenaline and this contraction was antagonized by the alpha-receptor blocking agent, thymoxamine.2. The cumulative log dose-response curves to noradrenaline in the presence of thymoxamine were moved to the right of and parallel to the curve for noradrenaline alone. The blockade was surmountable and reversible.3. The quantitative criteria for simple competitive antagonism were satisfied. When log (x - 1) was plotted against pA(x) the points fitted a straight line with a slope (-n) of 0.91. The pA(2) for thymoxamine was 7.54 and the mean value for log K(2) was 7.82. These values are in approximate agreement with those previously reported for animal isolated arterial strips.

Arteries↗