Why are drug development programs growing in size and cost? A view from industry.
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Drug Approval↗
Biomedical subjects
J F Niblack
Publications and source records attributed to J F Niblack.
Use of a synthetic adjuvant in an effective vaccination of monkeys against malaria.
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Adjuvants, Immunologic↗
CP-20,961: a structurally novel, synthetic adjuvant.
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Adjuvants, Immunologic↗
Studies with low molecular weight inducers of interferon in man.
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Animals↗
Letter: Clotrimazole and rheumatoid arthritis.
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Animals↗
N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl) propanediamine: antiviral activity and interferon stimulation in mice.
CP-20,961, N,N-dioctadecyl-N', N'-bis(2-hydroxyethyl)propanediamine, is an antiviral drug with low acute toxicity in mice. Parenteral injection of this compound protected mice against lethal infections with encephalomyocarditis and Semliki Forest viruses and effectively suppressed pox formation by vaccinia infection. Maximal antiviral effects were observed when CP-20,961 was administered 6 to 12 h before infection. An interferon detected in plasma 12 to 20 h after the drug was given appeared to mediate these effects. Comparison of the minimal effective and lethal doses in mice established a therapeutic index of 300.
Animals↗
Relationship of biological activities of poly I-poly C to homopolymer molecular weights.
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Animals↗
A phage-initiated polysaccharide depolymerase in Pseudomonas putida.
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Bacteriophages↗
Density heterogeneity in Pseudomonas putida bacteriophage preparations.
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Bacteriophages↗