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J F Pasternak

Publications and source records attributed to J F Pasternak.

42 records · Page 3Linked to original sources
PubMed1977

Ventricular dilation preceding rapid head growth following neonatal intracranial hemorrhage.

We describe two patients in whom ventricular dilation began within a week of neonatal intraventricular hemorrhage and preceded rapid head growth and clinical signs of increased intracranial pressure by days to weeks. The posthemorrhagic ventricular dilation is readily demonstrated in the neonatal period by computerized tomography of the cranium. These data indicate the importance of careful follow-up of survivors of intraventricular hemorrhage, early demonstration of ventricular dilation and prompt therapeutic intervention to prevent brain injury.

Cephalometry↗
PubMed1975

On the "selectivity" of the Golgi-Cox method.

The randomness of the impregnation of layer IV cortical neurons by the Golgi-Cox method (Van der Loos, '56) has been assessed directly in Barrel C-1 of the mouse SmI. All Golgi-Cox impregnated neurons and unimpregnated neurons which were revealed with a Nissl counterstain were counted and measured in ten cerebral hemispheres cut tangential to the pia overlying the barrel field. The percentage of Golgi stained neurons varied considerably in different preparations from 0.73% to 2.26% with an average of 1.29%. The size distributions of both the Golgi impregnated and Nissl stained cells are similar but the difference of the means is statistically significant. However, if the means are equated there is no statistical difference in the two populations. When the Golgi precipitate is removed and the cells re-measured following Nissl staining there is a systematic reduction of the perikaryal cross-sectional area which is compatible with the differences in the means observed for the two populations as a whole. Finally, the frequency with which Golgi impregnated neurons are found in the barrel sides and hollows parallels the frequency with which Nissl stained neurons are observed in these two locations. We conclude that this variant of the Golgi method impregnates barrel neurons randomly. The value of this information for quantitative studies of cerebral cortex is discussed as is the potential of the system for elucidating some of the mechanisms responsible for Golgi impregnation.

Animals↗
PubMedDate not supplied

Neonatal asphyxia: vulnerability of basal ganglia, thalamus, and brainstem.

Two infants who suffered acute intrapartum asphyxia resulting in severe neonatal encephalopathy are described. Although computed tomography revealed no abnormalities, magnetic resonance imaging documented unequivocal lesions in the thalamus, basal ganglia, parasagittal cortex, brainstem tectum, and midline cerebellum in one patient and in the basal ganglia and parasagittal cortex in the other. Thus, magnetic resonance imaging was more sensitive than computed tomography in detecting acute brain damage after neonatal asphyxia and may become an important tool in improving our understanding of the relationship between adverse perinatal events, neonatal encephalopathy, and neurologic morbidity.

Asphyxia Neonatorum↗
PubMedDate not supplied

Flunarizine does not delay the development of generalized seizures by amygdala kindling.

Adult rats underwent amygdala kindling after the administration of vehicle, flunarizine 20 mg/kg/day, or flunarizine 40 mg/kg/day. Stimuli were delivered thrice daily at current intensities twice after-discharge threshold (ADT). Flunarizine did not alter initial or post-kindling ADT and did not affect the latency (number of stimuli) to the first stage 5 seizure. Apart from a tendency to increase the latency between the first and the 4th stage 5 seizures, flunarizine had little if any effect on amygdala kindling in this protocol.

Amygdala↗