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Biomedical subjects

J F Seeger

Publications and source records attributed to J F Seeger.

At least 37 records · Page 2Linked to original sources

Digital subtraction angiography in head and neck radiology.

Intravenous digital subtraction angiography (IVDSA) was used to evaluate 44 patients with suspected otolaryngologic abnormalities. Sixteen had IVDSA for pulsatile tinnitus or suspected glomus tumor of the petrous bone. Nine patients were evaluated because of pulsatile neck masses, and 12 others had suspected tumors of the neck, face, and paranasal sinuses. Seven had IVDSA following head and neck trauma. The technique of examination is described. The current indications of IVDSA in head and neck radiology are discussed. It is concluded that IVDSA is a suitable substitute for conventional angiography for many otolaryngologic conditions and, because of its safety, can be used more liberally.

Adult↗

Intravenous digital subtraction angiography of the nearly occluded internal carotid artery.

Three patients with nearly occluded internal carotid artery origins were evaluated with intravenous digital subtraction angiography and subsequently had successful carotid endarterectomies. The angiographic features are described. Although conventional arterial angiography offers superior spatial resolution and selectivity, the thorough mixing of blood and contrast medium that occurs with the intravenous technique minimizes the tendency toward layering beyond a high-grade stenosis, which may occur with selective arterial injection. In cooperative patients, the intravenous digital technique may be sufficiently reliable in the detection of the nearly occluded internal carotid artery to obviate conventional selective common carotid angiography.

Aged↗

Radiologic evaluation of the carotid arteries.

In recent years the radiologist has been faced with a host of new imaging modalities which provide structural as well as physiologic information about the carotid arteries. Although conventional intra-arterial angiography is considered the standard of comparison for precise anatomic definition of the cervical and intracranial carotid arteries, it is being replaced in many instances by other techniques. CT scanning may provide valuable information regarding the relationship of the carotid arteries to soft tissue structures in the neck, and dynamic CT scanning has been used to measure cerebral blood flow. Other noninvasive techniques, such as B-mode scanning and Doppler imaging and spectral analysis, can provide accurate information about carotid stenoses and occlusions, although mostly limited to the region of the common carotid bifurcation. The recent development of digital subtraction intravenous angiography provides a revolutionary new and safe way to evaluate the entire carotid arteries, from their origins to their intracranial branches. The advantages and disadvantages, as well as the current roles of these modalities in the radiologic evaluation of the carotid arteries, will be discussed.

Adolescent↗

Intracranial applications of digital subtraction angiography.

Digital subtraction angiography (DSA) is becoming an important method of studying the intracranial vascular structures. In patients being evaluated for cervicocerebral atherosclerosis, patency of and flow patterns in the major intracranial arteries can be determined. Quantitative as well as qualitative data on relative hemispheric contrast transit times are obtainable. Intracranial aneurysms and vascular malformations can be demonstrated by intravenous DSA, but this technique is unlikely to replace selective intraarterial catheter angiography for the definitive work-up of these conditions. In selected cases, vascular tumors of the intracranial compartment and skull base can be satisfactorily evaluated by intravenous DSA, particularly if precise and intricate anatomic detail is not required. The dural venous sinuses are optimally demonstrated by this modality. Postoperative intravenous DSA is useful for determining the results of surgical treatment of certain conditions, and is suitable for assessing the patency of surgical bypass grafts. The disadvantages of using intravenous DSA for intracranial studies include poorer spatial resolution as compared to conventional angiography, superimposition of vessels, and serious degradation of image quality by patient motion. When greater selectivity and better resolution are required, intraarterial DSA can be performed. Advantages of intraarterial DSA over conventional angiography include the availability of immediate subtraction images, the ability to use dilute concentrations of contrast agent, and lesser film cost. Intraarterial DSA shortens procedure time when therapeutic embolization is performed.

Brain Neoplasms↗

Neuroradiology of the skull base.

Newer imaging modalities, especially high resolution computed tomographic scanning, have radically altered and expanded the role of radiology in the evaluation and management of lesions affecting the skull base. The location, extent, and tissue characteristics of these lesions can be determined with greater precision than ever before. When necessary, diagnostic and therapeutic angiography can be performed more rapidly and more safely with digital subtraction techniques. In the near future magnetic resonance imaging may prove to be an even more precise imaging tool than computed tomography. Magnetic resonance studies may also determine physiologic and biochemical properties of lesions that are not possible to evaluate with any other techniques.

Brain Diseases↗

Digital subtraction angiography. Comparison of meglumine-Na diatrizoate with iohexol.

A slight improvement in image quality occurred with the use of iohexol when compared with meglumine-Na diatrizoate. There is less swallowing with iohexol, which gives better image registration when looking at the extracranial carotid arteries. A single significant tachycardia occurred with the ionic medium, but not with iohexol. Overall discomfort and minor adverse reactions were less with iohexol than with diatrizoate.

Adult↗

Comparison of iohexol with meglumine-Na diatrizoate for intravenous digital subtraction angiography.

Iohexol, a new non-ionic water-soluble contrast medium, was tested for digital intravenous angiography of the cervical and intracranial vessels. In a double blind study involving 40 adult patients, iohexol and meglumine-Na diatrizoate were compared for safety, patient tolerance, and radiographic image quality. Iohexol was shown to be safe and generally produced less patient discomfort, leading to a lower incidence of motion, swallowing or cough artifacts.

Adult↗

Intracranial applications of digital intravenous subtraction angiography.

The intracranial vessels of 175 patients were examined with digital intravenous subtraction angiography. The equipment and the technique of the examination are briefly described. Of these patients, 129 underwent intravenous cerebral angiography in conjunction with examination of the extracranial carotid arteries for suspected arteriosclerotic disease. Postoperative and occasionally preoperative studies of intracranial aneurysms and arteriovenous malformations were performed in 16 patients, patency and flow patterns of extracranial-to-intracranial bypass grafts were evaluated in 11 instances, and selected vascular cranial and intracranial neoplasms were studied in 16 cases. Venous sinus occlusion has also been diagnosed by this technique. In many instances, digital intravenous subtraction angiography can replace conventional cerebral angiography.

Adult↗

New implantable continuous administration and bolus dose intracarotid drug delivery system for the treatment of malignant gliomas.

A totally implantable system for the continuous and bolus delivery of intra-arterial chemotherapeutic agents to patients with malignant gliomas is described. The system utilizes an Infusaid pump (Infusaid Corp., Sharon, Massachusetts), which discharges the drug directly into the internal carotid artery and is percutaneously refillable. This system has been utilized experimentally in primates and in the treatment of six patients with malignant gliomas. It seems that this system can be utilized safely as an experimental technique in the treatment of malignant gliomas.

Adult↗

Digital video subtraction angiography of the cervical and cerebral vasculature.

A digital video subtraction angiography unit developed at the University of Arizona is described. The system allows the angiographic evaluation of the cervical and cerebral vasculature by means of intravenous injection of contrast material. The procedure is performed on outpatients and is reliable, safe, and economical. The authors have evaluated suspected arterial and venous occlusive disease, certain aneurysms and tumors, and postoperative results of vascular bypass procedures and aneurysm clipping. The clinical application of the technique is shown with appropriate case presentations.

Aged↗

Computed tomographic and angiographic evaluation of hemangioblastomas.

The computed tomographic (CT) and angiographic findings in 14 patients with proved cerebellar hemangioblastomas were reviewed. Although the CT scan was abnormal in all patients who had hemangioblastomas which produced symptoms, angiography was far more sensitive than CT in detecting hemangioblastoma nodules and was usually more specific in characterizing the lesions. Angiography is recommended in any patients with CT demonstration of a cerebellar cyst, whether or not a mural nodule is apparent, and in patients with von Hippel-Lindau disease who have an abnormal cranial CT scan.

Adult↗

The nearly occluded internal carotid artery: a diagnostic trap.

Nine cases of nearly occluded internal carotid artery (ICA) origins, usually simulating total occlusion, are presented. Correct diagnosis is aided by an awareness of the possibility of near occlusion of the ICA origin and by careful study of selective common carotid angiography with a long imaging sequence and subtraction. Carotid endarterectomy is the operative procedure of choice, since there may be startling apparent increase in size of the arterial lumen distal to the surgical repair. Many cases reported previously as internal carotid artery occlusion with successful endarterectomy may actually have been severe stenoses.

Aged↗

Radiology of cerebral vein occlusion without dural sinus occlusion.

The angiographic findings in eight patients having cerebral vein occlusion without dural sinus occlusion are presented. The role of other radiologic examinations is discussed. Occlusive disease involving the dural venous sinuses and/or cerebral veins is a more frequent cause of cerebral symptoms than is generally assumed. An increased awareness of the variable clinical and computed tomographic manifestations is recommended, with liberal recourse to more definitive angiography in suspected cases.

Adult↗

Prospective comparison of epidural venography and iophendylate myelography in the diagnosis of herniated lumbar disks.

Fifty consecutive patients with suspected herniated nucleus pulposus at L4-5 or L5-S1 were evaluated prospectively with both epidural venography and iophendylate myelography. The two procedures were compared with respect to diagnostic accuracy, ease of performance, and complications. Evaluation of both the L4-5 and L5-S1 disk space levels was attempted in every patient, for a total of 100 levels. Surgical confirmation was obtained for 37 levels in 30 patients. While epidural venography is useful, myelography remains the procedure of choice.

Adult↗