PubMed Health⌕ Search

Biomedical subjects

J F Sei

Publications and source records attributed to J F Sei.

7 recordsLinked to original sources
PubMed1983

[Familial portuguese type amyloid polyneuropathy. Attempt at a pathogenetic interpretation].

The pathogenesis of familial portuguese amyloid polyneuropathy, a form of hereditary peripheral neuropathy is at present uncertain. Our hypothesis is that there may be a genetic modification in the metabolism of the Schwann cell. Normally this cell produces myelin, however with genetic modification perhaps it could switch its production to the protein precursor for amyloid. Therefore, the abnormality would reside primarily in the nervous tissue with the amyloid deposits being secondary but contributing to the axonal degeneration.

Amyloid↗
PubMedDate not supplied

[Kaposi's sarcoma complicating long-term corticotherapy for severe asthma].

Kaposi's sarcoma frequently develops in patients with immune deficiency which may be drug-induced (corticosteroids, immunodepressants). We report a case of Kaposi's sarcoma in a 75-year old man who had been taking oral prednisone continually for 7 years as treatment of severe asthma. Data from the literature clearly show that corticosteroid therapy may trigger the development of Kaposi's sarcoma in patients who usually possess several other pathogenetic factors of that disease, such as pre-existing immune deficiency, environmental (viruses) or genetic factors. In some cases, withdrawing corticosteroids may result in complete remission of the cutaneous lesions.

Aged↗