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Biomedical subjects

J F Soothill

Publications and source records attributed to J F Soothill.

At least 91 records · Page 5Linked to original sources
PubMed1977

Serum immune complexes and disease activity in lupus nephritis.

Raised levels of circulating soluble immune complexes were found in sera of 21 of 29 patients with lupus nephritis. They correlated well with clinical disease activity in the group as a whole and with the course of individual patients. In 2 patients, high-dose methylprednisolone reduced levels of immune complexes and led to clinical improvement. The size of the IgG complexes was studied in 7 patients. The complexes were very large (2-5-4X10(6) M.W.) in 6, but only the 4 with diffuse proliferative glomerulonephritis had medium-sized IgG complexes (1-1-5X10(6) M.W.) as well.

Adolescent↗
PubMed1977

A defect of the alternative pathway of complement.

The sera of patients defective at opsonization for yeast phagocytosis fix haemolytic complement poorly following incubation with the alternative pathway complement activators, inulin and bacterial endotoxin. This suggests that the defect lies early in the alternative pathway of complement.

Adult↗
PubMed1977

A test for antigen--antibody complexes in human sera using IgM of rabbit antisera to human immunoglobulins.

A simple semi-quantitative test for soluble antigen--antibody complexes using characterized non-human reagents and permitting analysis of their constituents is described. The agglutination of immunoglobulin-coated latex particles by rabbit IgM antibodies to the immunoglobulin is inhibited by complex-containing sera. No inhibition is obtained with monomer immunoglobulins. Semi-quantitative measurement of complexes may be made by electronically counting residual unagglutinated latex particles. The new method of linking proteins to latex by DNP coupling permits the technique to be applied to all constituents of complexes; immunoglobulins, complement and antigens. A new method of decomplementing sera by EDTA-Sigma cell-IgG absorption allows analysis of sera without the false positives and false negatives other methods give. The test gave positive results for IgG complexes in most of twenty-four patients with SLE nephritis. IgA complexes were identified in a patient with Henoch-Schonlein purpura nephritis.

Animals↗
PubMed1977

HLA in eczema and hay fever.

The presumed HLA haplotype A1:B8 was more frequent and the combination of A3 and B7 was less frequent in allergic subjects presenting with eczema, than in those presenting with hayfever. A1:B8 was most frequent (36%) in eczema complicated by asthma and/or hay fever, and least frequent (5%) in hay fever alone, considerably above and below the frequency in the general population (17%).

Adolescent↗
PubMed1976

HLA antigens and atopic features in steroid-responsive nephrotic syndrome of childhood.

Atopic systems were more common in children with steroid-responsive nephrotic syndrome (S.R.N.S.) than in matched controls, and HLA-B12 was more common in children with S.R.N.S. than in adult controls. Atopic symptoms (particularly hayfever), positive prick tests with grass pollen antigens, and a higher mean serum concentration of IgE antibody to timothy grass pollen were more common in nephrotic children with HLA-B12 than in those without HLA-B12. There was also an increased frequency of the haplotype HLA-A1 and HLA-B8, mainly among the non-atopic patients.

Adolescent↗
PubMed1976

Cystic fibrosis heterozygosity in the pathogenesis of allergy.

47% of cystic fibrosis (C.F.) heterozygotes had positive prick skin tests of 1 or more of 9 antigens and 53% had histories of allergic disease, both occurring significantly more often than in a control group. Since 1 in 20 of the population are C.F. carriers, this would contribute to allergy in the community.

Allergens↗
PubMed1976

Predisposing factors and the development of reaginic allergy in infancy.

In a prospective study of fifty-eight newborn infants of parents with reaginic allergy, twenty-seven developed eczema and twenty-eight positive prick tests to one or more of six antigens during the first year of life. These reaginic manifestations were related to presymptomatic transient IgA deficiency. The development of positive skin tests was also related to HLA A1 B8, and to season of birth. The order of frequency of positivity was Dermatophagoides, grass pollens, cat fur, feathers and cow's milk. The skin tests were often positive in infants in whom serum IgE was not detected. The eczema disappeared and the skin tests became negative in some infants at the end of the first year. This work suggests that sensitization in the new-born period is important in the subsequent development of disease.

Antibodies↗
PubMed1976

Defective opsonization. A common immunity deficiency.

Serum opsonization of yeasts for phagocytosis by normal polymorphonuclear leucocytes was defective in 11 of 43 children with unexplained frequent infections. The children had a range of infections, largely bacterial, and only 3 had diarrhoea and rash in infancy. A similar defect in at least 6 of the 9 mothers of these children (of either sex), with normal function in the fathers, suggests that the defect was primary and was transmitted by an unusual form of dominant inheritance. Four of 72 healthy adults and 1 of 11 children with unrelated disease showed similar defective function, but the incidence of the defect in the patients with frequent infection was significantly greater than this. The defective function can be corrected, in vitro and in vivo, by normal plasma at concentrations too low to be effective alone. This suggests that there is a defective factor rather than an inhibitor, and that different factors are limiting in normal and in defective plasma. Sera from affected members of the same family do not correct each other, but defective sera from different families usually do.

Adult↗
PubMed1976

Association of cystic fibrosis with allergy.

Immediate skin hypersensitivity to various inhalant allergens was present in 59% of 123 children with cystic fibrosis (CF), a much higher percentage than in the general population. This is consistent with the idea that atopy arises as a result of impaired handling of antigen at mucosal surfaces. The allergic CF children had more chest infections, a worse chest x-ray appearance, and lower peak expiratory flow rates. Allergic diseases were also frequent in the CF obligate heterozygotes (32% of mothers and 26% of fathers). It is suggested that the heterozygotes may also have a mucosal abnormality resulting in defective antigen handling.

Adolescent↗
PubMed1976

Differential protein clearances and response to treatment in Nigerian nephrotic children.

Remission followed prednisolone therapy in 9 out of 21 Nigerian children with the nephrotic syndrome who had highly selective proteinuria (CG/CA less than 15%). Of these, 5 patients have remained well off all treatment during a follow-up of nearly 5 years, 4 have relapsed more than once but have responded to further courses of prednisolone. 3 of 21 with less selective proteinuria also remitted but all relapsed and only one of these has responded again. The other two have relapsed and further courses of prednisolone have not totally abolished their proteinuria though they are asymptomatic and in good health. Toxicity (hypertension, sometimes with encephalopathy and infection) was commoner in the patients with less selective proteinuria treated with steroids than in those with highly selective proteinuria. 3 steroid-sensitive patients who had had repeated relapses became free from relapse off all treatment after a course of cyclophosphamide, given during steroid-maintained remission. All but 2 of the renal biopsies taken were regarded as abnormal. The lesions were less severe in those who responded than in those who did not. There is some evidence to suggest that Plasmodium malariae may be a cause of some of the steroid-sensitive disease, as well as the steroid-resistant.

Age Factors↗