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Biomedical subjects

J F Stalder

Publications and source records attributed to J F Stalder.

At least 91 records · Page 5Linked to original sources
PubMed1985

[Migration of polynuclear neutrophils in vivo. Standardization of the technic].

The migration of neutrophils across a skin barrier is a commonly employed method for the study of the inflammatory response. This report aims at comparing the leukocyte migration in the presence of two different chemoattractants : autologous serum and pool of serum. The reproducibility of this method has proved to be increasing by using duplicate skin chambers in 30 healty volunteers. The neutrophil migration with the pool of serum appears more homogeneous than with autologous serum. These results permit to obtain a standard curve of the neutrophil migration using a pool of serum.

Cell Migration Inhibition↗
PubMed1984

Variations in cutaneous zinc concentrations after oral administration of zinc gluconate.

The assessment of zinc levels after oral administration of 100 mg of zinc gluconate was performed over a 72-hour period in 3 sectors: plasma, blister fluid and epidermis. The results show that zinc taken orally reaches the epidermis after 72 h and indicate the existence of an intermediary compartment between plasma and epidermis, represented by blister fluid, in which zinc concentration is 243.9 +/- 32.2 micrograms/l, that is, the ratio blister fluid/plasma = 0.33.

Administration, Oral↗
PubMed1984

[Cutaneous achromia and malignant melanoma].

A cutaneous depigmentation occurring either far, or the primary tumour, or about the excision scar, or appearing in different other conditions was noted 29 times among 500 cases of malignant melanoma. Before excision, a vitiliginous depigmentation was present only in two patients. Nevertheless 9 patients observed a vitiligo after surgical excision of the tumour (2.5 years after, as an average) this proportion must conjecturally increase thereafter and so represent a minimal score. Twice, an achromic halo was obvious around the primary melanoma. In seven patients there was evidence of secondary depigmentation around the excision. Seven times a localized achromia was observed on the site of BCG-application or DNCB-test. Two patients had a halo-naevus (Sutton naevus). These varying achromias accompanying malignant melanoma were largely studied in animal pathology (horse and chimpanzee). They are usually in animals a factor of good prognosis. This good prognosis was likewise related in human malignant melanoma, but our series is against the assertion of any prognosis significance.

Female↗
PubMed1983

[Alcoholic neuroacropathy. Recent diagnostic and pathogenic attainments].

The authors report the results of a prospective study of 28 patients with alcoholic neuroacropathy or the Bureau and Barrière syndrome. The investigations included biochemical analysis of the alcoholism, electrophysiological studies and, in 4 cases, electron microscopy of the musculocutaneous nerve biopsy. Bone scintigraphy with foot and hand scans was carried out in all cases for a more exact and above all, earlier diagnosis of the neurological osteoarthropathy. The clinical syndrome was attributed to a polyneuropathy with a large sensory component of the alcoholic "dying back" variety in all cases. High VGM levels associated with high serum IgA levels appears to be a biochemical diagnostic criteria of this condition. The latter parameter was not closely related to the hepatocytic status of the patient but suggests a direct or indirect effect of the neuropathy on humoral immunity. All cases had characteristic bone scans with high uptake at points of mechanical stress of the anterior part of the foot (first metatarsophalangeal joint). This finding, which is also observed in alcoholic sensory neuropathy without trophic disturbances prompts the authors to define a preacropathic state and an evolutive and pathogenic outline of the disease.

Alcoholism↗
PubMed1982

[Eosinophilic fasciitis and Hodgkin's disease].

A case of eosinophilic fasciitis (EF) associated with Hodgkin disease is described. In eight previously published cases, EF was associated with immunologic diseases, such as autoimmune marrow aplasia. The relation between EF and Hodgkin disease should be studied by investigating the physiopathologic meaning of eosinophils in both conditions.

Aged↗
PubMed1982

[Functional anomalies of polymorphonuclears in Papillon-Lefèver disease (author's transl)].

Polymorphonuclear functions were studied in 3 patients of the same brotherhood with Papillon-Lefèvre disease (hyperkeratosis palmaris and plantaris and acute periodontosis resulting in loss of teeth) who developed severe and recurrent infections. Chemotaxis, oxygen consumption and production of H2 O2 were investigated by polarography, O2 production by quantitative reduction of nitroblue tetrazolium and iodination by the Pinus and Klebanoff technique. functional anomalies of polymorphonuclears involving chemotaxis, induced O2 consumption and H2 O2 production were detected in all three patients. This study confirms the presence of polymorphonuclear functional anomalies in patients with Papillon-Lefèvre disease. Analysis of the family tree of the patients, which went back to 1761, showed that this was probably not a chance association.

Adult↗