Biomedical subjects
Publications and source records attributed to J F Weekers.
A study was made during 1994 about microbiological contamination on the donor eyes before enucleation of whole globe. We studied the efficiency of the decontamination method by checking sterility of corneal storage medium after two days. We give results of serological tests on 252 donors.
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A comparative study of four preservation medium was made (Corneal Storage Solution, K-Sol, RPMI Hepes buffer, RPMI bicarbonate buffer). After a five days preservation delay there is no statistical difference between the percentage of the endothelial cellular mortality amongst the three first medium. In the fourth medium the cellular mortality is statistically higher. For longer preservation delay between 5 and 15 days, only the corneas preserved in K-Sol medium have a cellular mortality under 20% and could be used for keratoplasty.
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The endothelial cell density of 44 eyes after an acute attack of angle-closure glaucoma is statistically lower than the cellular density of 174 control eyes. The decrease in endothelial cell density increases the risk of edematous corneal dystrophy, more specially after surgery (e.g. cataract extraction). The modifications in corneal endothelial cell density are compared with the alterations of the iris after a crisis of angle-closure glaucoma.
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A retrospective specular microscopic study of 118 clear corneal grafts shows that the endothelium of these grafts is progressively destroyed during the two first years. The reduction of cellular density is rapid at the beginning of postoperative period, stabilizing after two years. The comparison of endothelial cellular density in fresh non selected grafts versus grafts preserved in culture seems to indicate a longer survival of preserved grafts. This study shows the utility of wide-field specular microscopy in the follow-up of clear corneal grafts. This technique furnishes useful information for postoperative management and long-term prognosis.
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A double-staining technique allowing calculation of the percentage of dead endothelial cells in corneas during medium-term storage is described. A positive correlation was found between the thickness of the cornea and the time since death, and between the percentage of dead endothelial cells and the thickness of the cornea. A negative correlation existed between age and cellular density of the endothelium. Conclusions of these data provides practical applications for the selection of corneas for keratoplasty.
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Human corneas from enucleated eyes get thicker during perfusion with B.S.S. On the contrary, their thickness decreases when perfused with T.C. Earle solution. Addition of reduced glutathion and adenosine does not change the results obtained with T.C. Earle. Histological study of the endothelium after a 24 hours perfusion demonstrates a better conservation of the cells with T.C. Earle and T.C. Earle glutathion--adenosine than with B.S.S.
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