Biomedical subjects

J F White

Publications and source records attributed to J F White.

112 records · Page 7Linked to original sources

PubMedDate not supplied

The function and fate of neutrophils at the inflamed site: prospects for therapeutic intervention.

Neutrophils play a key role in the immediate non-specific immune response, and defects in their function increase host susceptibility to a range of infective agents. However, excess activation and/or delayed clearance of these cells from an inflamed site can lead to significant tissue damage. Neutrophil priming by agents such as endotoxin, granulocyte macrophage colony stimulating factor (GM-CSF), platelet activating factor (PAF) and tumour necrosis factor-alpha (TNF alpha) may play a pivotal role in modulating the adhesive and secretory properties of these cells. Priming also appears to affect the survival of neutrophils by delaying constitutive apoptosis. The unique signal transduction events that control neutrophil priming and apoptosis, and particularly the importance of the phospholipase C and phosphoinositide 3-kinase pathways, suggest opportunities for selective pharmacological intervention.

Apoptosis↗

PubMedDate not supplied

Symptomatic carotid pathology detected by duplex ultrasound with minimal disease on angiography.

Carotid duplex ultrasound has been shown to give a more thorough picture of carotid plaque morphology than a carotid arteriogram. As a result, the question has arisen regarding what should be done for the patient who presents with classical hemispheric transient ischemic attacks (TIA) with ulcerative carotid plaque as documented by carotid duplex ultrasound, but with minimal disease on arteriography. This article presents a case illustration of this problem.

Aged↗

PubMedDate not supplied

Thoracic outlet syndrome with arm ischemia as a complication of cervical rib.

Thoracic outlet syndrome is the causative factor in less than 5% of patients with upper extremity ischemia. Congenital bony abnormalities (cervical rib) are most often responsible for the arterial complications of this syndrome. This article presents the case report of a patient who presented with ischemia of an upper extremity caused by embolization from subclavian artery stenosis and an aneurysm secondary to cervical rib. The treatment plan included excision of the cervical rib, repair of the subclavian artery aneurysm and a bypass graft which achieved a satisfactory outcome.

Adult↗

PubMedDate not supplied

Developing an international nursing partnership with Nicaragua.

With health conditions in the "least developed countries persisting at levels that are so limiting and destructive of human potential ... as to be unacceptable to the global community", WHO has put out a call for mandates to address these problems with "new approaches ... new partnerships." One answer to this call has come from the US' Duquesne University School of Nursing, which has founded an education and service partnership with Nicaragua that can serve as a "grass roots" model others can follow.

Humans↗