STUDIES ON THE KINETICS OF NAD-DECOMPOSITION.
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Biomedical subjects
Publications and source records attributed to J FODOR.
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An epidemiological study of the prevalence of heart disease in a representative rural population in Jamaica was carried out in 1962. Six hundred adults aged 35-64 years were selected at random from an agricultural population of which a census had been taken previously, and this report describes the clinical and electrocardiographic findings in 548 of these subjects.It is clear from the results of this survey that symptoms and physical signs of heart disease are common in this population; electrocardiographic evidence of myocardial damage-frequently interpreted as due to myocardial ischaemia-has also an unexpectedly high prevalence for an ethnic group in which a number of careful pathological studies have shown myocardial infarction and occlusive coronary artery disease to be comparatively rare.Much of the heart disease found was wholly unexplained, and it is thought that many of these subjects may have a type of cardiomyopathy of unknown etiology. A number of reports from the tropics and subtropics have drawn attention to this problem, but this is, so far as is known, the first investigation of its epidemiology.
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Thiopentone anaesthesia in dogs and rats was accompanied by a sharp fall in blood nonesterified fatty acids and a small increase in blood sugar. No pronounced changes in the blood concentrations of cholesterol, phospholipids or fatty acid esters were observed. Ether anaesthesia had no effect on the blood non-esterified fatty acids in rats. The fall in non-esterified fatty acids during thiopentone anaesthesia is therefore not related to the state of anaesthesia itself.
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