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Biomedical subjects

J Fabregas

Publications and source records attributed to J Fabregas.

6 recordsLinked to original sources

Effect of oil and dispersant on growth and chlorophyll a content of the marine microalga Tetraselmis suecica.

Low hydrocarbon concentrations stimulated the growth of Tetraselmis suecica, whereas higher concentrations (200 ppm) inhibited growth. The content of chlorophyll a in this microalga was affected in a similar way. Crude oil had the most marked effects. Dispersant SEAKLIN-101-NT and mixtures of oil and SEAKLIN-101-NT did not show selective toxicity for the microalga, although inhibitory effects could be observed at high concentrations.

Chlorophyll

Tetrafungin, a new polyene macrolide antibiotic. I. Fermentation, isolation, characterization, and biological properties.

A new polyene macrolide antifungal antibiotic, named tetrafungin, was isolated from the cultured mycelium of a Streptomyces strain. Fermentation, isolation, physico-chemical and biological properties of the antibiotic are described. Its UV absorption spectrum and its physico-chemical characteristics place this antibiotic in the group 2.2.2.3 of the Berdy classification.

Anti-Bacterial Agents

Tetrafungin, a new polyene macrolide antibiotic. II. Taxonomy of the producing organism and comparison with nystatin by means of high performance liquid chromatography.

Tetrafungin, a new polyene macrolide antibiotic, is produced by a Streptomyces strain identified as a new subspecies of Streptomyces albulus and named Streptomyces albulus subsp. tetrafungini. Tetrafungin and nystatin have been investigated and compared by HPLC. It has been demonstrated that tetrafungin and nystatin differ qualitatively in, at least, one component, and quantitatively in their relative amounts of common components.

Anti-Bacterial Agents

Differentiation of Candida guilliermondii varieties by lectin-like substances from marine algae.

Lectin-like substances of 54 marine algae, corresponding to 30 red algae and 24 brown algae, were studied to estimate the agglutination activity against Candida guilliermondii. Extracts of Dictyopteris membranacea, Bifurcaria bifurcata, Halidrys siliquosa, Ascophyllum nodosum, Fucus serratus and F. spiralis algae showed selective agglutinating activities for C. guilliermondii "sensu stricto" and some of its varieties. According to their response to agglutination (positive or negative), certain algal extracts enabled the differentiation of varieties of C. guilliermondii independently of the titre values. Three extracts of brown algae were sufficient to identify 4 varieties of C. guilliermondii. The results suggest that lectin-like substances from marine algae may be valuable reagents as assistant tools for the identification of yeast strains.

Agglutination