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Biomedical subjects

J Faller

Publications and source records attributed to J Faller.

At least 37 records · Page 2Linked to original sources
PubMed1995

The interaction between hepatic arterial and portal venous blood flows; simultaneous measurement by transit time ultrasonic volume flowmetry.

Intra-operative measurement of the afferent circulation of the liver, namely hepatic artery and portal venous flow was carried out in 14 anesthetized patients with carcinoma of the splanchnic area, mainly in the head of the pancreas, by means of transit time ultrasonic volume flowmetry. The hepatic artery flow, portal venous flow and total hepatic flow were 0.377 +/- 0.10; 0.614 +/- 0.21; 0.992 +/- 0.2761/min, respectively. The ratio of hepatic arterial flow to portal venous flow was 0.66 +/- 0.259. There was a sharp, significant increase in hepatic arterial flow (29.8 +/- 6.1%, p < 0.01) after the temporary occlusion of portal vein, while the temporary occlusion of the hepatic artery did not have any significant effect on portal venous circulation. The interaction between hepatic arterial flow and portal venous flow is much in dispute, but, as the data presented here show, there is no doubt that the decrease in portal venous flow immediately gives rise to a significant increase in hepatic artery circulation.

Blood Flow Velocity↗
PubMed1994

["Serrated" adenoma--a little known type of colorectal tumors].

Eight cases and review of the literature on serrated adenoma of the colon were reported. This distinct entity of colorectal tumors was described in recent years. The tumors contain hyperplastic and adenomatous areas. Their tendency for malignant transformation is similar to pure adenomas to contrary to benign hyperplastic polyps. Three tumors of eight reported cases were pedunculated, while five were sessile. Four patients were operated on because of narrowing of intestinal lumen by the tumors. Malignant transformation of tumors was observed in three cases. Several biopsies were performed before major operations. Histology showed false benign hyperplastic tumors. Importance of multiple tissue sample for histology was emphasised. Electron microscopy showed disturbed differentiation and pathological mucus production of tumor cells.

Adenoma↗
PubMed1994

The afferent circulation of the transplanted liver during the recirculatory phase in dogs.

The relationship between the changes in portal venous and hepatic arterial blood flows, e.g. the interaction of the two vascular systems in the liver always was a much disputed question, although it has tremendous significance in the practice of transplantation, and the explanation has been known since 1981, when Lautt published the so-called "adenosine washout theory" /9/. According to our earlier observations the decrease of portal pressure of flow generally and consistently led to an increase in hepatic artery flow. At the same time, changes in hepatic artery flow or pressure seemed to produce only inconsistent effects on the portal circulation. In the present experiments liver transplantations were carried out on mongrel dogs by Starzl's method /14/. Electromagnetic flow probes were placed on the hepatic artery and the portal vein before removal of recipient's liver, and after completion of all vascular anastomoses of newly inserted liver, e.g. in the recirculatory phase of OLTX. The flow probes were connected to Hellige electromagnetic flowmeter, portal venous and systemic arterial pressures were recorded too. The control HAF was 241 +/- 23 ml/min, the average PVF was 517 +/- 47 ml/min before removal of the recipient's liver. In the recirculatory phase the HAF increased to 414 +/- 39 ml/min, by 71 +/- 12% (p < 0.001). The PVF decreased in most animals after OLTX. The decrease was in average -40.2 +/- 3.5% (p < 0.001). The THBF calculated by adding the HAF and PVF showed a small, but not significant decrease during recirculation. The control THBF was 758 +/- 50 ml or 39.0 +/- 3.1 ml/min/kg. In the recirculatory phase 754 +/- 48 ml/min HBF could be measured, respectively. The systemic arterial pressure slightly decreased, portal vein pressure rose in most animals after OLTX, accordingly there was a substantial increase of portal inflow resistance and of prehepatic arteriolar resistance, decrease of hepatic arterial resistance. The decrease of PVF after OLTX can be explained by a progressive fluid accumulation in the liver parenchyma and increased sinusoidal and portal inflow resistance. The prolonged and continuous increase of hepatic artery flow during recirculatory phase of OLTX may be due to the decrease of portal flow. The exact mechanism, by which a change in portal flow leads to arteriolar dilatation, can be most probably explained by "adenosine washout theory" of Lautt.

Animals↗
PubMed1994

Blood flow measurement in patients with hepatocellular carcinomas.

Since the data regarding the afferent circulation of the liver in patients having primary hepatocellular carcinoma are controversial or missing. Authors carried out the measurement of hepatic arterial and portal venous flow intraoperatively by transit time ultrasonic volume flowmetry. In patients with primary hepatocellular carcinoma the hepatic artery flow increased to 0.55 +/- 0.211 compared with the control value of 0.37 +/- 0.102 1/min (p < 0.01). The portal venous flow decreased from 0.61 +/- 0.212 1/min to 0.47 +/- 1/min (p < 0.01). Due to the opposite changes in the afferent circulation the total hepatic blood flow did not change significantly. The ratio of hepatic arterial flow to portal vein flow elevated to 1.239 +/- 0.246 in patients with hepatocellular carcinoma, which is the double of the basic control value (0.66 +/- 0.259 1/min). After resection this ratio practically did not change. The surgical intervention, that is the resection of the liver did not alter the hepatic artery and portal venous flow significantly, although the total hepatic blood flow has decreased significantly (p < 0.01). The prominent and marked increase in the ratio of hepatic arterial flow may be attributed to the decrease of portal venous flow caused by the primary hepatocellular carcinoma. The decrease of venous flow can be explained most probable by compression and infiltration of the intrahepatic branches of the portal vein. As we pointed out the decrease in portal venous circulation consequently causes increase in hepatic arterial flow.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1993

Enantioselective and nonenantioselective degradation of organic pollutants in the marine ecosystem.

Enantiomeric ratios of 11 chiral environmental pollutants determined in different compartments of the marine ecosystem by chiral capillary gas chromatography and chiral high-performance liquid chromatography allow discrimination between the following processes: enantioselective decomposition of both enantiomers with different velocities by marine microorganisms (alpha-HCH, beta-PCCH, gamma-PCCH); enantioselective decomposition of one enantiomer only by marine microorganisms (DCPP); enantioselective decomposition by enzymatic processes in marine biota (alpha-HCH, beta-PCCH, trans-chlordane, cis-chlordane, octachlordane MC4, octachlordane MC5, octachlordane MC7, oxychlordane, heptachlor epoxide); enantioselective active transport through the "blood-brain barrier" (alpha-HCH); nonenantioselective photochemical degradation (alpha-HCH, beta-PCCH).

Adipose Tissue↗
PubMed1993

Complications following major abdominal surgery in cirrhotic patients.

The morbidity and mortality associated with major abdominal surgical interventions in 34 histologically proven cirrhotic patients are analyzed by the authors. The surgical interventions were carried out as urgent, absolute and elective indications. Thirty-seven general and surgical complications were observed following major abdominal surgery in 34 cirrhotics. Seven out of 34 patients died, giving a mortality rate of 21%. Suture-line insufficiency, peritonitis, sepsis and other inflammatory processes turned out to be the most common complications. Statistical analysis showed that the Child criteria, prothrombin level and white blood cell count were useful prognostic factors.

Abdomen↗
PubMed1992

[Malignant fibrous hystiocytomas of unusual localizations].

25 cases of malignant fibrous histiocytomas of different localisation were diagnosed in the St. John's Hospital (Budapest, Hungary) in a 10-year period from 1982 to 1992. In the present study ten patients are reported with rare localisation of this tumor caused abdominal complications. Special attention is payed to diagnostic difficulties. The importance of morphological diagnosis is emphasized because modern therapeutic methods favourably influence the prognosis of this tumor.

Aged↗
PubMed1992

[Clinical aspects and management of a retroperitoneal abscess].

14 patients with retroperitoneal abscess have been collected by the authors since June 1, 1988. The retroperitoneal abscess of multifactorial origin can be considered as a secondary disease. The physical clinical signs (e.g. psoas rigidity sign, palpable mass, costolumbal sensitivity) play central role in setting up of diagnosis, and these signs were present in more than 75% of the cases. The physical signs generally indicate advanced retroperitoneal abscess, and at the same time the contour of psoas muscle disappears and concavity of lumbal vertebras can be seen on plane abdominal X ray film. The exact diagnosis was achieved in mean 45 days after the on set of complaints, this fact urges, that the up-to-date imaging modalities (US, CT, NMR) should be applied earlier in septic conditions of unknown origin. Retroperitoneal surgical intervention was performed in their patients, in the future the percutaneous drainage procedure has to be considered as first intervention for retroperitoneal abscess. Retroperitoneal abscess secondary to malignant disease has unfavorable prognosis, 2 out of 14 patients with retroperitoneal abscess died, both of them had underlying malignancy.

Abscess↗
PubMed1992

[Prinzmetal angina pectoris causing diagnostic and therapeutic problems].

A 53 year old patient was hospitalized because of retrosternal oppression which was unrelated to effort and recurred in the early morning hours. An esophageal diverticulum and a hiatal hernia were found. The patient had complaints in spite of medical therapy and an operation was performed because of his oesophageal disorders. After operation the patient had the same pain. A cardiologist was asked, who suggested Prinzmetal variant angina. During arteriography coronary artery disease was found. Coronary bypass surgery was indicated and performed, after that procedure the patient was and remained free of any complaints. This observation reaffirmed Prinzmetal original statement "The key to the diagnosis ... is the taking of a painstaking history".

Angina Pectoris, Variant↗
PubMed1991

[Complications of abdominal surgery in patients with liver cirrhosis].

The morbidity and mortality of major abdominal surgical interventions in 34 histologically proven cirrhotic patients are analysed by the authors. The surgical interventions were carried out by urgent, absolute and elective indications. 37 general and surgical complications could have been observed following the major abdominal surgery of 34 cirrhotics. 7 out of 34 patients died. Suture-line insufficiency, peritonitis, sepsis and other inflammatory processes turned out most frequently among the complications. The Child criteria, the prothrombin level and white blood cell count proved to be useful prognostic factors by statistical analysis.

Abdomen↗
PubMed1991

Foot and ankle disorders resulting from Lyme disease.

Ten cases of Lyme disease involving the foot and ankle are reported. Onset of symptoms was months to years before diagnosis. A variety of clinical foot and ankle problems resulted. Careful case histories and serologic testing resulted in proper diagnosis and treatment.

Adolescent↗
PubMed1991

Gastrointestinal angiodysplasia.

In the recent four years, 8 cases of gastrointestinal angiodysplasia (a.d.) were observed by the authors. Analysing the conclusions drawn from the patients course of disease, they found a.d. to be the cause of an unknown gastrointestinal bleeding. a.d. can be basically diagnosed by angiography. It is often associated with liver cirrhosis or arteriostenosis. The treatment of a.d. is surgical. The recurrence and repeated appearance of bleeding can be expected even after a thoroughly performed resection.

Adolescent↗
PubMed1991

Complications following major abdominal surgery in cirrhotic patients.

The morbidity and mortality of major abdominal surgical interventions in 34 histologically proven cirrhotic patients are analysed by the authors. The surgical interventions were carried out based on vital absolute and elective indications. 37 general and surgical complications were observed following the major abdominal surgery of 34 cirrhotics. 7 out of 34 patients died, the mortality was 21%. Suture insufficiency, peritonitis, sepsis and other inflammatory processes occurred most frequently among the complications. The Child criteria, the prothrombin level and white blood cell count proved to be useful prognostic factors.

Abdomen↗
PubMed1990

[Liver tumors caused by androgenic steroids].

11 hepatocellular tumours associated with the long term use of androgenic steroids were reported. Three of the tumours were seen on the basis of diffuse peliosis hepatis. One of the 11 tumours was benign hepatocellular adenoma. In one case malignant transformation of an adenoma was observed. Nine tumours proved to be highly differentiated hepatocellular carcinomas. Metastases were observed in three cases. Histological and electron microscopical peculiarities of the tumours were the accumulation of glycogen in the cytoplasm of tumour cells, nuclear inclusions, and great number of peculiar formed vessels. The last case is a rarity. One year after the needle biopsy implantation of hepatocellular carcinoma was observed with several tumorous metastases at the site of the previous biopsy. The authors suggest regular hepatic control by ultrasound examinations of patients on sexual steroid hormones.

Adult↗
PubMed1990

Inflammatory pseudotumour of the liver.

In view of their own case, authors review the diagnostic and clinical characteristics of the inflammatory "pseudotumours" of the liver. They state that this liver disease is important from the differential diagnostic point of view. The inflammatory pseudotumours should be basically differentiated from malignant tumours in which the imaging procedures and their repetition are significant. Authors review their case in connection with 13 cases collected from the literature.

Aged↗
PubMed1990

Prognostic factors and treatment tactics in the surgery of liver abscesses.

The prognostic factors of 21 patients with pyogenic liver abscess were analyzed. It was stated that survival is unfavourably influenced by hyperbilirubinaemia, the mixed bacterial population, the associated diseases as well as the tumorous process. As a result of portal antibiotic perfusion, there was no difference in the mortality rates of multiple and solitary liver abscesses. Based on the analysis of the prognostic factors, the surgical tactics is developed, i.e. a need for surgical exposure is supported, which imposes three tasks: exposure of the abscess/es, management of the primary process inducing the abscess and introduction of a cannula for portal antibiotic perfusion. Besides some criteria, although the author do not have experience in this field, they suggest the use of percutaneous drainage controlled by echography or CT, basically because of the lower mortality rate.

Aged↗
PubMed1989

Management and care of the precanceroses of the stomach in the 11-year material of our clinic.

The present paper surveys over the past 11 years the cases of the endoscopic laboratory of our clinic which, according to criteria accepted all over the world, were considered as precancerous states of the stomach. According to the authors' experience, an advance in the management of malignant diseases can only be expected by referring to operation the cases in their early stage, if the examination and regular control of the patients are carried out with the predisposing factors being considered by a team involving the surgeon, endoscopist and pathologist.

Adenocarcinoma↗