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Biomedical subjects

J Fallingborg

Publications and source records attributed to J Fallingborg.

At least 37 records · Page 2Linked to original sources
PubMed1989

pH-profile and regional transit times of the normal gut measured by a radiotelemetry device.

The pH of the gut lumen was measured in 39 healthy persons using a pH-sensitive, radiotransmitting capsule. Thirteen persons were studied twice. The location of the capsule was determined by X-ray. The pH rose from 6.4 in the duodenum to 7.3 in the distal part of the small intestine. In 17 persons the pH dropped by 0.1-0.8 pH units during the last hours of the small intestinal transit. The pH was 5.7 in the caecum, but rose to 6.6 in the rectum. Gastric residence time was 1.1 h, small intestinal transit was 8 h, and colonic transit time was 17.5 h (median values). The results provide a firmer basis for prediction of the level, and the rate of release of active substance from pH-dependent sustained-release oral preparations.

Adolescent↗
PubMed1989

Severe complication to phytomenadione after intramuscular injection in woman in labor. Case report and review of literature.

A 28-year-old woman in labor developed a severe anaphylactoid reaction, necessitating acute cesarean section, with subsequent neonatal death, after receiving 10 mg of phytomenadione (Konakion) by the intramuscular route. Allergologic investigations revealed no type I reaction against the drug, and the symptoms were considered to be caused by drug-induced intolerance. Prophylactic administration of phytomenadione to the infant rather than to the parturient is recommended.

Adult↗
PubMed1989

99mTc-sucralfate scintigraphy in inflammatory bowel disease.

Technetium-99m-labeled albumin-sucralfate was orally administered to 11 patients (Crohn's disease, 8; ulcerative colitis, 3) and 3 healthy volunteers. Serial scintigraphy was performed, and scintigraphic interpretations were compared with radiographic and endoscopic findings in an open study. We were not able in any patient to relate the scintigraphic findings to the localizations of inflammatory bowel disease, nor could we distinguish the scans in the patients from the scans of the healthy volunteers. We conclude that 99mTc-albumin-sucralfate scintigraphy is of no value in the detection of inflammatory bowel disease.

Adult↗
PubMed1989

Serum selenium concentration in patients with ulcerative colitis.

Selenium deficiency may be implicated in the pathogenesis of some human diseases, including colon cancer. The incidence of carcinoma of the colon is increased in patients with ulcerative colitis. We measured the serum concentration of selenium (S-Se) in 20 patients with ulcerative colitis and 20 sex-, age-, height- and weight-matched controls. Although no significant difference was found in mean S-Se between patients and controls (patients: S-Se = 0.93 mumol/l, controls: S-Se = 0.98 mumol/l), the S-Se level decreased with increasing extension of the disease (p less than 0.02). No correlation was found between S-Se and the sex, age, height, or weight of the person or between S-Se and the activity or duration of the disease. The inverse correlation between S-Se and the extension of the disease may be caused by a decreased absorption of selenium from the diseased colon in ulcerative colitis. The significance of the decreased S-Se in patients with extensive disease is unknown, but the possibility exists that this may further increase their risk of developing colonic cancer.

Adolescent↗
PubMed1988

Severe persistent cerebellar dysfunction complicating cytosine arabinoside therapy.

A case of persistent cerebellar dysfunction following high-dose cytosine arabinoside (Ara-C) treatment of acute myelogenous leukemia is reported. The symptoms developed after a cumulative dose of 24 g/m2, and 6 months after the start of symptoms, the signs of cerebellar damage were unchanged. The symptoms aggravated during a subsequent low-dose therapy with Ara-C, 15 mg twice daily. This supports the presumption that this adverse effect is caused by the cumulative dose rather than by high plasma concentrations.

Adult↗
PubMed1986

HLA antigens in a family with Behçet's syndrome.

A family is described in which 3 of 12 members suffered from Behçet's syndrome. Four members, including the three patients with Behçet's syndrome suffered from recurrent aphthous stomatitis. These four family members possessed the HLA-haplotype HLA A2, B15, Cw3, DR4. However, one relative had inherited the same HLA-haplotype without showing any symptoms of the disease. Genetic influence from the actual HLA-haplotype may interact in manifestation of the syndrome.

Adolescent↗
PubMed1986

Abnormal duodenal loop in patients with irritable bowel syndrome.

The frequency of an abnormal duodenal loop (AD) was investigated in 36 patients with irritable bowel syndrome (IBS) and in a sex- and age-matched control group of patients with Crohn's disease. The frequency was significantly higher in the patients with IBS than in the control group (41% versus 18%; p less than 0.02). Among IBS patients with AD, the frequency of food-provoked pain was higher than in IBS patients with a normal duodenum (65% versus 21%; p less than 0.01). We conclude that AD may be one of the reasons for complaints in IBS.

Adult↗
PubMed1986

Microscopic appearance of the esophageal mucosa in a consecutive series of patients submitted to upper endoscopy. Correlation with gastroesophageal reflux symptoms and macroscopic findings.

The histologic finding of basal-layer hyperplasia and papillosis as consequences of gastroesophageal reflux still constitute an area of controversy. Consequently, a prospective study of symptoms and endoscopy and biopsy interpretation was undertaken in 200 patients consecutively submitted to upper endoscopy, whereof 12 were excluded. Complete agreement among all three variables was found in half of the patients and harmony between two of the variables in one fourth. In the last fourth the outcome was positive in one variable only, equally distributed among the symptoms, endoscopy, and histology. It is concluded that histology is of considerable value in gastroesophageal reflux disease.

Esophagoscopy↗
PubMed1985

Decreased gelatin-binding fibronectin in patients with chronic inflammatory bowel diseases.

The plasma fibronectin concentration (PF) was measured in 48 patients with chronic inflammatory bowel disease (CIBD) and in 48 age- and sex-matched healthy controls, using electroimmunoassay and a functional (gelatin-binding) assay. Whereas no difference in immunochemically measured PF was found between the two groups, patients with CIBD had significantly lower gelatin-binding PF than healthy controls (p less than 0.001). Immunochemically measured PF increased, whereas functionally measured PF tended to decrease with increasing disease activity.

Adolescent↗
PubMed1985

Atraumatic rupture of the spleen in periarteritis nodosa.

A case of atraumatic rupture of the spleen is described. The underlying disease was found to be periarteritis nodosa. Involvement of the spleen is common in this disease, but to our knowledge atraumatic rupture of this organ in a patient with histologic verified periarteritis nodosa has not previously been reported. In the present case the splenic rupture was the incident which led to the diagnosis. A possible mechanism of the rupture is proposed.

Aneurysm↗