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J Farrell

Publications and source records attributed to J Farrell.

At least 73 records · Page 4Linked to original sources
PubMed1980

Molecular limits on the size of a genetic locus in Drosophila melanogaster.

This report places outer limits on the size of the DNA region required for expression of a Drosophila gene. This region, termed the unit of expression, includes not only the structural gene but also any cis-acting sequences that modulate its activity. The locus we have chosen, Sgs-4, codes for one of the glue proteins secreted by larval Drosophila salivary glands. Cytological deficiencies have been identified that eliminate sequences on one side or the other of Sgs-4 without affecting its expression. The ends of these deficiencies have been localized accurately with respect to restriction endonuclease sites in and near the locus. These endpoints limit the Sgs-4 structural gene and essential flanking sequences to a 16- to 19-kilobase region of the X chromosome. The results also show that there is no DNA sequence rearrangement in the Sgs-4 region during development of either the polytene larval salivary glands or adult flies.

Animals↗
PubMed1980

Audiometric and radiologic findings in acoustic tumor.

We surveyed 13 proven cases of neuro-otologic tumors to determine the value of audiometric and radiologic studies. Angle myelography was positive in 100% of cases tested. CT scan with intravenous enhancement was positive in 91% of cases tested. Stapedial reflex decay or tone decay was positive in 100% of cases tested. A practical management plan is suggested for follow-up of patients with vertigo, unilateral tinnitus, and hearing loss.

Adolescent↗
PubMed1980

Immunological responses of L. donovani infection in mice and significance of T cell in resistance to experimental leishmaniasis.

The parasite burdens of livers and spleens of several strains of mice following infection with L. donovani were determined for a period of over 120 days. The parasite loads of the spleens and livers were correlated with the development of immunity to reinfection, footpad sensitivity and antibody titres. The strains of mice studied could be divided into two groups--those highly susceptible and those relatively non-susceptible. The antibody in the susceptible strains appeared 12 days after infection and increased thereafter. The antibody in the less susceptible strains appeared some time later and remained at the same level throughout the test period. In strains CAFl, C57B1/6 and BALB/c skin reactivity to Leishmania antigen developed at the time when the parasite burden had decreased from its peak. Skin reactivity never developed in DBA!l mice, the most highly susceptible strain, and in A/j the least susceptible strain. The development of resistance to reinfection with L. donovani following i.v. and i.p. infection was observed in C57Bl mice. Upon cell transfer from these immune animals, it was found that protective immunity was mediated through the thymus-dependent lymphocytes. Serum from immune mice was not able to confer immunity to the recipient animals.

Animals↗
PubMed1979

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Dentistry↗