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Biomedical subjects

J Fedrick

Publications and source records attributed to J Fedrick.

At least 37 records · Page 2Linked to original sources
PubMed1973

Influence of pregnancy spacing on outcome of pregnancy.

To assess the significance of the length of time between two pregnancies on the outcome of the second we used information collected by the British Perinatal Mortality Survey of 1958. From questionnaires on the 16,994 singleton births in the first week of March 1958 and the 7,117 singleton stillbirths and neonatal deaths in March, April, and May 1958 we abstracted information on the date and outcome of any preceding pregnancy. The interpregnancy interval was taken as the length of time between this preceding pregnancy and the last menstrual period before the index pregnancy. The most important factors influencing pregnancy spacing were outcome of the preceding delivery, social class, and maternal age. When these variables had been taken into account we found that the length of interpregnancy interval had little effect on stillbirth rates. High neonatal death rates, however, occurred when interpregnancy intervals were less than six months (P <0.005), though longer intervals had no significant effects.

Adolescent↗
PubMed1973

Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.

The files of the Oxford Record Linkage Study were used to identify 223 infants delivered to 168 epileptic women as the result of 218 pregnancies. There were six stillbirths, two of which were grossly malformed. It was shown that the population of epileptic mothers differed significantly from the total reproducing population in respect of social class. Each pregnancy resulting in a livebirth was therefore matched exactly for social class, civil status, maternal age, parity, hospital, and year of delivery with three control deliveries resulting in livebirths. The defects noted at birth were abstracted from the Record Linkage files, and any subsequent hospital admissions or deaths of the children were also abstracted.There were highly significant excesses of congenital abnormalities among the infants born to epileptic mothers (13.8% of livebirths had some degree of defect of congenital origin compared with 5.6% of controls, P <0.0005). It was shown that neither the frequency with which the mother had fits nor the length of time she had had the epilepsy seemed to bear any relation to the frequency of defects in the offspring-with the exception of the two mothers who developed epilepsy in the first

Abnormalities, Drug-Induced↗
PubMed1972

Reported influenza in pregnancy and subsequent cancer in the child.

A longitudinal study of 1,959 infants born in the first week of March 1958 to mothers who were reported to have had influenza during pregnancy revealed an incidence of cancer of 4.1 per 1,000 compared with only 0.8 per 1,000 among the 14,791 infants of mothers who had not had influenza.This increase was caused by cases of leukaemia and other neoplasms of lymphatic and haematopoietic tissue (I.C.D. 200-209) (P <0.0001).Data from the reports of the Registrar General for England and Wales were used to estimate the number of infants born in each year from 1955 to 1964 who subsequently died of cancer before 5 years of age. The rates for each year were compared with an estimate of the prevalence of influenza during the preceding winter. After allowing for the overall trend in the cancer death rate, a highly significant correlation was shown with deaths attributed to causes classified as I.C.D. 200-209 (P <0.005), but not with deaths attributed to other cancers. The increase in the risk of developing these neoplasms among children whose mothers had influenza is estimated to be not less than fourfold. Even so the risk remains small (3 to 4 per 1,000).

Child↗