Biomedical subjects

J Fernández Alonso

Publications and source records attributed to J Fernández Alonso.

15 recordsLinked to original sources

PubMed1998

[Acute interstitial pneumonia (Hamman Rich syndrome)].

We report the case of a 65-year-old woman with no history of respiratory disease who suffered onset of dyspnea after an episode of pseudoinfluenza. Dyspnea progressed such that within 15 days it was triggered by minimal effort. The patient died 15 hours after admission to our hospital, with a clinical picture of adult respiratory distress. Autopsy allowed us to rule out several diseases and arrive at a diagnosis of acute interstitial pneumonia, consistent with clinical course, anatomical and pathological findings as described in the literature.

Acute Disease↗

PubMed1992

Primary pure choriocarcinoma of the liver.

We report a pure choriocarcinoma of the liver studied at necropsy. The tumour was diagnosed ante-mortem and treated by chemotherapy with no satisfactory response. Previous cases of hepatic choriocarcinoma are reviewed and criteria to diagnose this extragonadal neoplasm are recommended.

Autopsy↗

PubMed1992

[Diffuse pulmonary hemorrhage due to capillaritis in a patient with typical periarteritis nodosa and necrotizing glomerulonephritis. Relationship with overlapping vasculitic syndrome and Wegener's granulomatosis].

Clinical and pathological postmortem study of a patient with NPA which died due to a fulminant pulmonary hemorrhage. In the postmortem study, diffuse pulmonary capillaries was observed as the cause of the disease, as well as lesions of necrotizing glomerulonephritis with granulomas, within the framework of a typical NPA. Correlation with the NPA-type overlapping polyangiitic syndrome and microscopic polyarteritis are discussed, as well as the correlation between the latter and Wegener's granulomatosis.

Capillaries↗

PubMed1991

[Cytomegalic inclusion disease in a patient with systemic lupus].

Cytomegalovirus (CMV) infections acquire characteristics of special severity when they occur in patients suffering primary or secondary cellular immune depression. We present a case of pneumonia with fatal evolution caused by CMV, in a female patient suffering systemic lupus erythematosus. The underlying disease, of recent onset, presented multiorgan involvement (skin, joints, kidney, blood) which could be controlled with steroids and azathioprine. The patient presented a few days after she had overcome an acute outbreak of the disease, a febrile status with rapid evolution with a diffuse pulmonary interstitial infiltrate. Circulating anti CMV antibodies were detected, of IgM class, by a enzyme-immunoassay. The necropsy showed a multiorgan infiltrate (liver, lung, skin, kidney) with cells containing cytomegalic inclusion.

Adolescent↗

PubMed1990

[Granulomatous hypophysitis probably of autoimmune etiology. A case diagnosed post mortem].

We report a case of idiopathic granulomatous hypophysitis diagnosed at autopsy in a 69-year-old female who, after endocrine coma, died from gastrointestinal hemorrhage. Immunohistochemical studies disclosed a predominance of T-lymphocytes in the inflammatory pituitary infiltrates. In addition to hypophysitis, lymphocytic thyroiditis and adrenalitis lesions and atrophic gastritis were found. These findings, consistent with autoimmune disease, are similar to those reported for lymphocytic hypophysitis, and raise the possibility that both types of hypophysitis are different aspects of the same condition.

Aged↗

PubMed1990

[Abscessing rhombencephalitis caused by Listeria in an iummunodepressed patient].

The cerebral trunk infection by Listeria monocytogenes is a very rare process, with only 24 described cases and only 2 in immunodepressed patients. We present a new case of cerebral trunk encephalitis caused by Listeria in a patient diagnosed of Polyarteritis nodosa on steroids and cyclophosamide treatment and fatal evolution, and whose hemoculture, spinal fluid culture and cranial CT scan did not contribute to the diagnosis. A necrotizing lesion in the protuberance with mesencephalic extension was observed in the necropsy study in which intra- and extracellular Gram + and silver positive bacilli were detected. Since L. monocytogenes was suspected as the causative agent, indirect immunofluorescence was performed on histological preparations with hyperimmune anti-L. monocytogenes serum giving a clearly positive result. In our case, this technique permitted the etiological diagnosis in the absence of positive cultures.

Aspergillosis↗

PubMed1988