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Biomedical subjects

J Fernández Seara

Publications and source records attributed to J Fernández Seara.

17 recordsLinked to original sources
PubMed2006

Prevalence of Helicobacter pylori infection in the general adult population of the province of Ourense.

OBJECTIVES: to determine the prevalence of Helicobacter pylori infection in the general adult population of the province of Ourense. MATERIAL AND METHODS: a cross-sectional study was carried out with a randomly selected populational sample. The diagnosis of Helicobacter pylori infection was reached using the 13C-urea breath test. RESULTS: three hundred and eighty-three subjects were studied, with a prevalence rate of 69.1% (95% CI: 61.7-75.1%); 69.8% (95% CI: 63.2-76.6%) in males and 68.4% (95% CI: 61.5-75.4%) in females (difference not statistically significant). Prevalence increases with age up to a maximum of 88.4% in the 45-54 years age group, and decreases thereafter to a rate of 57.1% in individuals over the age of 84 years. CONCLUSION: this study reveals that the prevalence rate of Helicobacter pylori infection is high in the general adult population of the province of Ourense. It increases with age until it peaks in the group of middle-aged individuals and is similar in both sexes.

Adolescent↗
PubMed2006

Risk factors associated with Helicobacter pylori infection. A population-based study conducted in the province of Ourense.

OBJECTIVES: to identify the relationship between Helicobacter pylori infection and various factors that have been described in other studies in the general adult population in the province of Ourense. MATERIAL AND METHODS: three hundred and eighty-three participants were enrolled in a study on the prevalence of Helicobacter pylori infection. All participants filled in a questionnaire under supervision, and the data obtained were examined by means of a univariate analysis. The odds ratio corresponding to each variable studied was calculated with their corresponding 95% confidence intervals. Furthermore, a multivariate analysis was performed. RESULTS: the univariate analysis revealed an association between infection and: age, place of residence during childhood, current social status based on the head of the family s profession, current blue collar/white collar profession of the head of the family, sharing a bedroom during childhood, type of drinking water, and contact with animals during childhood. No association was found with respect to the presence of dyspeptic symptoms. The multivariate analysis disclosed that only age is an independent risk factor associated with infection. CONCLUSION: age has been identified as the only independent risk factor associated with Helicobacter pylori infection in this population-based study. The univariate analysis has detected other factors. No association has been identified with respect to dyspeptic symptoms.

Adolescent↗
PubMed2005

Sedation at endoscopic units in Galicia: results of the "Sociedad Gallega de Patología Digestiva" inquiry.

AIM: To evaluate the human and material resources available for sedation, and the usual manner of handling them at endoscopic units in Galicia. METHODS: A prospective and descriptive study based on the performance, distribution, and analysis of a clinical practice inquiry. We requested information about endoscopies performed, available means for sedation, sedation monitoring, and level of sedation used in each procedure. RESULTS: Our inquiry was answered by twenty endoscopic units (thirteen were in public hospitals, and eleven performed complex procedures). Of these units, 80% had a pulse oximeter, 42% had continuous electrocardiography, 40% had a defibrillator, and 45% had a recovery area. The drug most commonly used in gastroscopies was midazolam (76%), and the combination midazolam-meperidine was most frequent in both colonoscopies (72%) and ERCPs (60%). An anesthesiologist was usually available for certain procedures in 15% of units, and as an exception in 65%. Of those inquired, 35% wished to have a full-time anesthesiologist in the unit, 25% wished to have an anesthetist only for certain procedures, and 35% on an exceptional basis. Finally, endoscopists considered that 83% of therapeutical gastroscopies, 87% of therapeutical colonoscopies, 98% of ERCPs, 95% of enteroscopies, and 98% of echoendoscopies deserved sedation. CONCLUSIONS: Although endoscopists consider that endoscopic procedures should benefit from sedation in a high proportion, the available resources to safely monitor patients are inadequate in some units.

Anesthesiology↗
PubMed2003

[Gastric epithelial polyps. A retrospective study 1995-2000].

OBJECTIVE: The analysis of the endoscopic and histological characteristics of all the gastric epithelial polyps diagnosed through endoscopy in our service during a period of 5 years, and the evaluation of the usefulness of the endoscopic monitoring after polypectomy. PATIENTS AND METHODS: Between January 1995 and January 2000 5,314 high digestive system endoscopies were carried out in the Gastroenterology Service of the Santa María Madre Hospital. Sixty-four gastric epithelial polyps were detected in 18 patients (10 men and 8 women) with a median age of 61.7 years. RESULTS: Sixty-three polyps were removed through endoscopic polypectomy, and one was biopsied because of its size (5 cm), 30 (46.87%) were hyperplastic polyps, 24 (37.5%) presented normal histological characteristics, 8 (12.5%) were adenomas and 2 (3.12%) were polypoid adenocarcinomas. 56.2% measured less than 6 mm and only 6.2% measured more than 11 mm. No patient presented simultaenous gastric adenocarcinoma. Only one complication was observed after the polypectomy, a hemorrhage that was treated successfully with local injection of adrenaline. During the follow-up no case of cancer was detected and the recurrence of the polyp was observed in 2/8 patients with adenoma. CONCLUSIONS: Gastric epithelial polyps are infrequent (0.33% gastroscopies); most of them (93.75%) measure less than 1 cm and they can be removed through endoscopy with safety. In our series, the most frequent histological type was the hyperplastic polyp (43.75%); polypoid adenocarcinoma constituted 3.12% of the cases, one of them with less than 6 mm. Endoscopic follow-up is considered absolutely essential after the polypectomy, especially in adenomatous polyps.

Adult↗
PubMed1995

[Comparative study of the efficacy and tolerance of 2 types of colon cleansing].

OBJECTIVE: To examine if (hypothesis): orally administered colon cleansing with 3 liters of balanced electrolyte/polyethylene glycol solution is superior to the standard method of bowel preparation with senna laxatives and sodium phosphate enemas. STUDY FACTORS: 1st) Quality of colon cleansing estimated by the attending endoscopist. 2nd) Patient tolerance. METHODS DESIGN: prospective randomized trial, blind to the endoscopist, comparing two methods of bowel preparation: group A received 3 L of the balanced electrolyte/polyethylene glycol solution the night before the procedure and group B was instructed to ingest 75 ml of a senna laxative the day before the colonoscopy and sodium phosphate enemas per rectum b.i.d. starting 2 days before the examination and again the morning of the procedure. Assessing criteria: 1st) Questionnaire filled by the attending endoscopist immediately after the completion of the colonoscopy. 2nd) Questionnaire filled by the patient the day after the procedure. PATIENTS INCLUSION CRITERIA: all the patients addressed to our Unit for colonoscopy (18 patients refused to participate). EXCLUSION CRITERIA: severe cardiovascular disease, decompensated diabetes mellitus and severe disease or neurological derangement that prevented collaboration (35 patients). Two hundred and sixteen patients were initially included, 110 in group A and 106 in group B; in 39 patients (18 in group A and 21 in group B) colonoscopy could not be completed for causes others than bowel preparation and were excluded for further evaluation by the endoscopist, thus, quality of bowel preparation was evaluated in 92 patients in group A and in 85 patients in group B; 83 patients (43 in group A and 40 in group B) did not answer the questionnaire, or did it incorrectly, thus, tolerance was evaluated in 67 patients in group A and in 66 patients in group B. RESULTS: In 2 patients in group A (2.2%) and in 9 patients in group B (10.6%) colonoscopy could not be completed because of solid stool (p = 0.045). Mucosal visualization was better in group A than in group B (p = 0.0108). A total of 11.9% of the patients in group A and 25.8% of the patients in group B found the preparation hard or very hard to tolerate (p = 0.0001), patients in this latter group presented more frequently abdominal cramps (p = 0.0004), and distress (p < 0.00001), and dizziness (p = 0.0031). Bad tolerance in group B was primarily due to the rectal enemas (p < 0.0001). CONCLUSIONS: Bowel preparation for colonoscopy with 3 L of orally administer balanced electrolyte/polyethylene glycol solution (PEG) results in a better colon cleansing and is better tolerated than the classical preparation consisting in oral purge and rectal enemas.

Colon↗
PubMed1993

[Ganglioneuroma of the duodenum].

Ganglioneuroma is an exceptional benign tumour of the duodenum and only three cases have been described previously. We report the case of a 71-year-old male in whom this pathology was incidentally discovered, as it usually happens with this type of tumour. Within rare duodenal nonepithelial tumours, gangliocytic paraganglioma is a fairly well defined entity characterized by a proliferation of neurons, Schwann cells, and endocrine-like epithelial cells. Ganglioneuroma lacks this last type of cells and represents and even rarer finding within tumoral pathology of the duodenum. The histopathogenesis of this tumor is discussed and there are theories that defend an hamartomatous origin against a neoplastic nature.

Adenocarcinoma↗
PubMed1991

[Agranulocytosis induced by captopril after 4 months of treatment].

A case of a patient treated by captopril who developed agranulocytosis and sepsis from pulmonary origin is presented. Shortly, we reviewed the pathogenesis of this complication and highlight the fact that in this patient this adverse reaction to captopril was late.

Agranulocytosis↗