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Biomedical subjects

J Fernández-Diez

Publications and source records attributed to J Fernández-Diez.

15 recordsLinked to original sources
PubMed1998

Prognostic significance of cutaneous depigmentation in Mexican patients with malignant melanoma.

BACKGROUND: The clinical significance of cutaneous depigmentary phenomena in patients with malignant melanoma is not clear. There are two varieties: 1) vitiligo (VIT), and 2) leukoderma acquisitum centrifugum (LAC). METHODS: In order to evaluate the outcome of our patients with malignant melanoma and skin depigmentation (VIT or LAC), the patients in this study with this association were retrospectively reviewed and compared with the total melanoma patients at the Oncology Hospital and the XXI Century National Medical Center of the Mexican Social Security Institute in Mexico City. RESULTS: Nine cases were found from 1985-1995. There were eight women and one man, their mean age was 63 years. Six melanomas were located in the foot, one in the leg, one in the anus and one in the neck. All were Clark's levels III, IV or V, and their mean tumor thickness was 5.7 mm. Four out of nine patients had regional lymph node metastasis. Six melanomas were associated with VIT and three with LAC. Three patients developed the depigmentation after chemo- or chemoimmunotherapy. All nine patients are alive (100%) with a mean follow-up of 55 months (9-141), eight out of nine have no evidence of tumor. CONCLUSIONS: From these data it may be concluded that the study patients with malignant melanoma and VIT or LAC have a higher-than-expected survival according to their prognostic factors. Therefore, the presence of the depigmentation phenomena must be looked for intentionally.

Adult↗
PubMed1993

[Hodgkin's disease with the nephrotic syndrome. A case report].

It is presented a child with Hodgkin's disease which at diagnosis present associated at nephrotic syndrome. Male of nine years old which present a ganglionic growing of left jugular chain of one year evolution without systemic symptoms and anasarca. Were underwent a ganglionic biopsy with histopathology report of Hodgkin's disease mixed cellular variety and renal biopsy with histopathology report of minimal change disease. The patient present remission of nephrotic syndrome in simultaneous form at the control of the disease. In the reported cases of nephrotic syndrome associated with Hodgkin's disease it not clear the physiopathology. In this patient were realized immunologic studies of renal tissues to treat to find a possible mechanism of action of the neoplastic cells on the basal glomerular membrane but we can not found.

Biopsy↗
PubMed1982

Occupational dermatitis from IPPD in tires.

A tire assembler developed contact dermatitis from IPPD, a rubber antioxidant. The lichenoid clinical pattern corresponded histologically to lichenified dermatitis. Tire assemblers appear to acquire contact dermatitis to this aromatic amine more frequently than any other workers in the tire manufacturing industry. Possible adjuvant factors and preventive measures are discussed.

Antioxidants↗
PubMed1980

Skin immunoflorescence in patients with systemic lupus erythematosus, SLE. Relationship between the immunohistochemical pattern and systemic activity.

19 SLE patients between 12 and 18 years of age were studied. In all cases a renal histological study was performed and patients received prednisone daily or on alternate days; 10 also received azathioprine. Patients were hospitalized for disease activity assessment from the clinical and biochemical standpoints. A healthy skin biopsy was simultaneously performed in the antero external face of the forearm and the fragment was subject to direct immunofluorescence study. IgG, IgM or C3 granular deposits were fund in six patients (33 per cent). Presence, type and intensity of deposits were related with other clinical and biochemical activity aspects, type of nephropathy, evolution and treatment time, and none was statistically significant. We can conclude that immune deposits in the skin of SLE patients can be useful as an auxiliary method for the diagnosis of this disease not having a relationship with the type and severity of the nephropathy or clinical activity of the disease.

Adolescent↗
PubMed1978

[Study of the pathogenicity of Conidiobolus coronatus in experimental animals].

The pathogenicity of a strain of Conidiobulus coronatus isolated from Aenolamia postica was investigated in 152 mice, 42 guinea pigs and 47 hamsters. Four routes of inoculation were used: intraperitoneal, subcutaneous, intratracheal and scarification in the oral mucosa. Each animal was inoculated 3 times at 3 week intervals. Animals were sacrificed at 1, 8, 15, 45 of 225 days after the first inoculation. Observations of macroscopic lesions (nodules, abscesses, adhesions, etc.) direct examinations, cultures and histopathological studies of different tissues were performed. The aforementioned lesions of tissue were the most frequently found and all of them were resolved by spontaneous cure. The animals inoculated intraperitoneally and subcutaneouslly presented the highest number of postive results. The histopathological features at the 1st and 8th days after inoculation showed an acute inflamatory infiltrate with well preserved fungus filaments; at the 15th day granulomas with giant cells were observed containing fragmented and disintegrated fungal hyphae; at the 45th and 225th days a fibrosis reaction was observed and no fungal filaments, could be found. In no animal was rhinoentomophthoromycosis never reproduced, and according to these results it is considered that either this strain is not a pathogen or its pathogenicity is very low.

Animals↗
PubMed1978

Acute massive pulmonary hemorrhage in systemic lupus erythematosus.

Acute massive pulmonary hemorrhage is described as part of the clinical picture of SLE. Seven patients had sudden onset of high fever, dyspnea, tachycardia, and cough with blood-tinged sputum that within hours progressed to massive hemoptysis and death. There were no vasculitis or other inflammatory lung changes found at autopsy. Only one of the seven reported cases survived when treated with 2 g of intravenous hydrocortisone daily. The mechanism of this pulmonary bleeding is unknown but seems to be an immune complex mediated phenomenon.

Adolescent↗
PubMed1978

Universal acquired melanosis. The carbon baby.

A Mexican child was born white and progressively became black. At the age of 21 months, the whole integument was deep black in the absence of other alterations. Electron microscopy showed a Negroid pattern in the epidermal melanosomes. Among the different forms of progressive mucocutaneous pigmentations previously described in the literature, we were unable to find a similar case.

Adolescent↗
PubMed1977

[Reiter's syndrome in children. Ultramicroscopic study of the synovial membrane].

The clinical picture of a 12 year-old boy with Reiter's syndrome, manifested by conjunctivitis, keratitis, polyarthritis and urethritis, is presented and compared with the other 26 boys and girls with this syndrome that have been reported elsewhere. Light microscopy and inmunofluorescence studies of synovial membrane showed nonspecific changes. However, with the electron-microscope two types of cellular inclusions were seen in both, synovial cells and macrophages. Such changes were similar to those described in adults with Reiter's syndrome.

Anti-Bacterial Agents↗
PubMedDate not supplied

Occupationally induced psoriasis.

Psoriasis of the hands may be triggered by work, especially in occupations involving physical trauma or contact with irritants. When limited to the hands and in absence of other typical lesions, diagnosis can be difficult particularly when coexisting with contact eczema. It is necessary to establish diagnostic criteria which help to establish a relationship between clinical manifestations and noxious stimuli at work. Prevention should be directed to early identification of cases and adequate preemployment physical examinations in order to avoid permanent disability.

Dermatitis, Occupational↗