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J Fernandes

Publications and source records attributed to J Fernandes.

164 records · Page 10Linked to original sources

[Spirometric alterations caused by hemodialysis. Their relation to changes in the parameters commonly used to measure hemodialysis efficiency].

The Forced Expiratory Volume in the 1st second (FEV1) and the Forced Vital Capacity (FVC) was determined before and after a hemodialysis (HD), in 61 patients suffering from chronic renal failure (CRF). Before and after the same HD the value of the following parameters were determined: Na; K; Cl; Urea; Creatinine, Ca; P and hematocrit. We found the following values: initial FEV1 91.68%, final FEV1 100.35%, (P less than 0.001); initial FVC 87.4%, final FVC 95.87% (P less than 0.001). The 61 patients were separated in two sub-groups. In the first the FEV1 variation less than or equal to 8%, while in the second it was greater than 8%. The mean variation of the other parameters was determined in both sub-group. No significant difference was found between them. On the other hand a significant correlation was found (r = 0.06, P less than 0.03) between the improvement of pulmonary function and the ponderal loss. The correction of the hydrosaline overload seems to be an important factor in the reported spirometric improvement.

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Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts.

OBJECTIVES: To evaluate the effect of therapeutic and pharmacologic concentrations of two non-steroidal anti-inflammatory drugs (NSAIDs), nimesulide and naproxen, on the synthesis of urokinase (uPA), plasminogen activator inhibitor (PAI-1) and interleukin-6 (IL-6) in human synovial fibroblasts isolated from osteoarthritis (OA) patients. METHODS: Urokinase, PAI-1, and IL-6 production were measured by specific ELISA. RESULTS: Nimesulide and naproxen induced a dose-dependent decrease in uPA synthesis. The two drugs, at therapeutic concentrations, exerted a stimulatory effect on the synthesis of PAI-1 whereas the synthesis of IL-6 was significantly reduced by both NSAIDs. CONCLUSION: The results of this study indicate some of the mechanisms by which nimesulide and naproxen could exert their effects on the arthritis process. The suppressive action of the two drugs on the synthesis of uPA, while stimulating PAI-1 production, may have a positive impact on the balance of plasminogen activator/inhibitor, which could help reduce cartilage catabolism.

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