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Biomedical subjects

J Fiedler

Publications and source records attributed to J Fiedler.

68 records · Page 4Linked to original sources
PubMed1977

[Analysis of etofenamate. Particular determination in biological material (author's transl)].

The determination of 2-(2-hydroxyethoxy)-ethyl-N-(a,a,a-trifluoro-m-tolyl)-anthranilate (etofenamate, active principle of Rheumon gel) following its isolation from biological material is reported. Depending on the method of extraction etofenamate, free and alkali-labile conjugated flufenamic acid, total conjugates or the sum of CF3-containing compounds (sum of metabolites) are isolated. Separation is achieved by TLC, quantitative determination is made by degradation to flufenamic acid and fluorimetric measurement in CCl4/trichloracetic acid at 372/445 nm. Etofenamate can be identified by TLC, derivatisation, UV- and fluorescence spectroscopy and differentiated from its metabolites. It is demonstrated that etofenamate is the main component of fenamates in inflamed tissue.

Animals↗
PubMed1976

Endocrine-metabolic response to acute starvation in human gestation.

During a 72 hour fast in pregnant women, significant decrements in the maternal plasma glucose concentrations, accompanied by a significant increase in the plasma placental lactogen (hPL) concentration, occur. At the same time, utilization of glucogenic amino acids, principally alanine, takes place. The mean postprandial glucose concentration in pregnancy is significantly lower than that of comparable nonpregnant women (70.5 +/- 1.7 versus 79.5 +/- 1.3 mg. per 100 ml., p less than 0.001). There appears to be a significant sparing effect on the maternal plasma glucose concentration during acute fasting which may be mediated through hPL. Concentrations of amniotic fluid and fetal plasma glucose from women undergoing fasting decrease in a manner parallel to that of the mother. Fasting provokes a mean rise in plasma hPL of 33.2 per cent over basal levels. This rise is still evident 72 hours after refeeding, after which it gradually returns to pretest concentrations. The infusion of alanine or arginine to pregnant women at the end of the fast produced increments in the peripheral maternal glucose concentration. The response was much greater with alanine than with arginine, demonstrating the increased gluconeogenic potential of this amino acid. The increment in human growth hormone (hGH) following alanine infusion was significantly greater than that observed after arginine administration. Hypoaminoacidemia was present in nonpregnant and pregnant women in response to fasting, but the decline was greater in pregnancy. Acute fasting in the first half of gestation appears to produce significant alterations in carbohydrate metabolism evidenced by profound hypoglycemia, hypoinsulinemia, and hypoaminoacidemia. This maternal deficit can be reflected in fetal substrate concentrations. The effect of these changes on fetal growth and development is speculative at this time.

Abortion, Therapeutic↗
PubMedDate not supplied

The receptor and neuron distribution in the cochlea of the bat, Taphozous kachhensis.

Cochlear receptors and spiral ganglion neurons in the inner ear of the bat, Taphozous kachhensis of the family Emballonuridae, were quantitatively analyzed on the basis of surface specimen technique, histological sections, and three-dimensional computer reconstruction. The length of the basilar membrane was 12.1 (+/- 0.4) mm. There were about 23,000 neurons in the spiral ganglion and about 1430 inner hair cells and 4635 outer hair cells in the organ of Corti. Cochlear neurons had two density maxima, one basal and one apical. Inner hair cells had basically the same distribution but less pronounced. Outer hair cells had only one density maximum in the apical region corresponding to the respective maxima of inner hair cells and cochlear neurons. Basal density maxima of inner hair cells and neurons are most probably involved in the analysis of echolocation signals, and presumably correlated with maximum sensitivity of the auditory system. A comparison with the bat, Nyctalus noctula of the family Vespertilionidae revealed a conspicuous similarity in some quantitative aspects of the cochlear structure. These particular similarities may be looked upon as convergent adaptations given by similar flight, hunting, and echolocation strategies in both bat species.

Animals↗
PubMedDate not supplied

Death concern and attitudes toward the elderly in nursing home personnel.

The present project investigated the relationship between death fear and threat, attitudes toward the elderly, and personal anxiety toward one's own aging in a group of 145 nursing home employees and a matched comparison group of 130 individuals who worked in non-death related occupations. Contrary to predictions, nursing home personnel did not have higher levels of death threat when compared to controls; in fact, control group subjects had higher levels of death concern on two dimensions of death fear (fear of the dead and fear of significant others dying). However, the results also indicated that increasing levels of death concern were associated with greater anxiety toward aging, especially in the nursing home sample, and nursing personnel displayed significantly fewer positive attitudes toward the elderly than did controls.

Adult↗