PubMed Health⌕ Search

Biomedical subjects

J Fielding

Publications and source records attributed to J Fielding.

At least 73 records · Page 4Linked to original sources
PubMed1969

Effect of sulphydryl inhibition on the uptake of transferrin-bound iron by reticulocytes.

Iron transferrin, the highly stable carrier of plasma iron, may be dissociated, under physiological conditions, by sodium thioglycollate, a reaction which involves the formation of iron thioglycollate complexes. This suggested that sulphydryl radicals, which are the active groups in thioglycollate and related compounds, may play a part in the uptake of iron by immature red cells from iron transferrin. If this were so, it could be predicted that the sulphydryl inhibitor, p-hydroxymercuribenzoate, would depress the uptake of iron by reticulocytes. It is demonstrated here that inhibition of uptake of transferrin-bound iron by reticulocytes, which have been exposed to micromolar concentration of p-hydroxymercuribenzoate, is virtually complete. It is suggested that sulphydryl-containing compounds are intimately involved in the process of iron uptake by immature red cells.

Humans↗
PubMed1968

Storage iron depletion in male blood donors: its significance for iron status in women.

Among 24 male blood donors without anaemia who had been giving a mean of 2.2 donations per year involving a mean blood loss of about 900 ml a year, 10 (41%) were found to be depleted of storage iron. This is somewhat higher but similar to the previously recorded findings in healthy women without anaemia. The results may well support a policy of limiting blood donation to twice a year in men and to once a year in women. Both men and women blood donors require medicinal iron after each donation. It is considered that storage iron depletion in non-anaemic women is not in the main related to pathological levels of menstrual loss but rather to inadequate dietary iron. Food iron in present-day diets should be supplemented.

Adult↗
PubMed1966

Differential ferrioxamine test in idiopathic haemochromatosis and transfusional haemosiderosis.

The differential ferrioxamine test measures the amount of body iron as ferrioxamine (Fv) chelated by a standard dose of desferrioxamine.Five patients with untreated, uncomplicated idiopathic haemochromatosis and one with transfusion haemosiderosis gave Fv in the range 1,948 to 2,462 mug./kg. (normal 110 to 500). One case of transfusion haemochromatosis with haemolytic anaemia and renal failure gave an Fv value of 8,019 mug./kg. Four patients with idiopathic haemochromatosis after therapeutic venesection gave Fv values of 212 to 885 mug./kg. One relative with a value for Fv of 776 mug./kg. was shown to have early cirrhosis by liver biopsy. Serial Fv measurement after venesection in this patient provided a preliminary assessment of the relationship between Fv values and available iron stores up to about 2,000 mg. iron. This relationship applies only when red cell survival is normal. Approximate figures for the range of available storage iron in 31 healthy men are deduced, namely, 200 mg. to 1,000 mg. (3 to 14 mg./kg.). The test should prove useful in the diagnosis of iron overload, in the screening of relatives for early haemochromatosis, and in the management of iron storage diseases.

Adolescent↗
PubMed1966

Iron chelation in haematomas at fracture sites.

Previous work suggested that during the catabolism of haemoglobin a physico-chemical form of iron was released which was more readily chelatable by desferrioxamine than normal storage forms, as ferritin-haemosiderin. Desferrioxamine chelation was therefore investigated in five patients with major fractures in which haemoglobin catabolism is greatly enhanced by the red cell destruction which proceeds in the associated haematoma. Considerable increases in the amounts of iron mobilized by desferrioxamine were observed from the second day after injury. In severe interstitial haemorrhage, these values tended to increase until 10 to 20 days, and sometimes were as high as chelation values seen in haemochromatosis. These results are considered to support the hypothesis that a highly chelatable form of iron is found at some stage during haemoglobin catabolism.

Adult↗
PubMedDate not supplied

'Sister, what's this?'.

Explore the source record for details and available documents.

Community Health Nursing↗