Immunosuppression in toxoplasmosis: preliminary studies in mice infected with louping-ill virus.
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Animals↗
Biomedical subjects
J Finlayson
Publications and source records attributed to J Finlayson.
Immunosuppression in toxoplasmosis: further studies on mice infected with louping-ill virus.
Mice were infected with an avirulent cyst-producing strain of Toxoplasma gondii and given injections of louping-ill virus 7 days later; control mice were given virus but not Toxoplasma. Test and control mice were then killed, in groups, 2, 4, 6, 8 and 10 days later. In the dually infected mice viraemia was later, greater and more prolonged; titres of virus recovered from brain and spleen were greater; production and haemagglutinating antibody to louping-ill virus was later and less, and inflammation in the brain was more severe, than in mice given virus alone. We suggest that T. gondii suppressed the immunity of mice, making them more susceptible to the virus, and that a significant proportion of the increased number of inflammatory cells observed in the brain could have been toxoplasma specific and not virus-specific and hence contributed to the increased susceptibility of the dually infected mice to louping-ill virus.
Animals↗
Effect of chronic Trypanosoma brucei infection on the course of louping ill virus infection in mice.
The course of louping-ill virus infection in mice chronically infected with Trypanosoma brucei was investigated. The mean survival time of mice infected with virus alone was 10.2 days, compared to 12.8 days in mice infected with T. brucei 14 days before virus challenge, and the cumulative mortality in the two groups was 62.5 and 90%, respectively. Virus was only inconsistently detected in the blood of mice given virus alone but was regularly present at high titers for up to 12 days in the blood of mice previously infected with T. brucei. Titers of virus in brains were also higher in dually infected mice, and encephalitis was of greater severity. These results indicate that the immunosuppressive effect of chronic trypanosomiasis may markedly increase susceptibility to acute virus infection. In addition, it is concluded that vector-vertebrate relationships of arthropod-transmitted viruses may be altered by concurrent trypanosome infection.
Animals↗
A behavioral manifestation of the development of interhemispheric transfer of learning in children.
Two hundred and fifty normal, right-handed children ranging from aged 5 to 15 were administered measures of grip strength, finger-tapping speed and the Tactual Performance Test. In order to assess the development of manual preference, analysis for each of the measures were performed on the left hand score as a percentage of the right hand score. Small age-related trends were found for the pure motor measures of speed and strength. In the case of the TPT, a clear age-related practice effect was found. The results were discussed in terms of the development of hemispheric cooperation.
Adolescent↗
Tactile-perceptual functioning in relation to intellectual, cognitive and reading skills in younger and older normal children.
Forty-eight 12- to 14-years-olds and 40 six- to eight-year-old normal boys and girls were distributed into two groups on the basis of the number of errors they made on several tests of tactile-perceptual ability. The groups were then compared on measures of intellectual, cognitive and reading ability. In the older group, children with poor tactile-perceptual skills performed significantly less well on the other measures than children with few tactile-perceptual errors. This relationship was not so clearly demonstrated in the younger groups. The results are discussed in terms of individual differences in brain function.
Adolescent↗