[A century and a half of the first surgical anesthesia].
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Biomedical subjects
Publications and source records attributed to J Firmat.
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A retrospective study of 500 consecutive cases of acute renal failure (ARF) in a period covering 1978 through 1991 is presented. A total of 316 females and 182 males with an average age of 46.4 years (14 to 84) had a global survival rate of 68%. Oligoanuric ARF was present in 77% of the patients and, except in 13 cases, all were dialyzed with varied techniques. The treatment plan consisted of early and repetitive dialysis, rational use of antibiotics, and parenteral and/or oral nutritional support. The patients have been divided into three main categories according to etiology: gyneco-obstetric, medical, and postsurgical cases, the latter having the poorest survival rate. With regard to ARF post-septic abortion, we strongly believe that a hysterectomy should not be carried out except in the presence of gangrene or proven uterine perforation, as surgery increases the morbomortality rate in these septic patients.
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Ten patients with acute renal failure post-septic abortion were studied. Two groups of patients are described in terms of duration of oliguria, number of dialysis per patient and maximal concentration of BUN during the acute episode of tubular necrosis. Despite different oliguric periods, when the patients reached 500 ml of urine volume in 24 hours, the recovery of diuresis was similar in both groups as well as the decrease of BUN concentration at the end of the hemodialysis period. Functional studies were carried out, up to an average of 10.5 years after the acute episode. Mean values for inulin and para-aminohippurate clearances were 107 +/- 11.53 and 534.6 +/- 62.9 ml/min./1.73 m2 in nonoliguric patients or those with a short period of oliguria. These values are not significantly different from the mean values of Wesson for normal women. On the other hand, reductions in both clearances were present in most patients who had a long period of oliguria (GFR: 84.9 +/- 4.2 and RPF: 418.1 +/- 33.1). These results demonstrate that the duration of oliguria at the time acute renal failure occurred is the most important factor influencing the rate and extent of long-term recovery of renal function.
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