Local anaesthesia for large loop excision of the cervical transformation zone: has prilocaine/felypressin less side effects than lignocaine/adrenaline?
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Biomedical subjects
Publications and source records attributed to J Foden-Shroff.
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OBJECTIVE: To evaluate whether routinely giving an antibiotic after loop diathermy excision of the cervical transformation zone reduced post-operative vaginal loss. DESIGN: Prospective, randomised, double-blind placebo controlled parallel study. PARTICIPANTS: Five hundred women undergoing loop diathermy excision in a colposcopy clinic. INTERVENTION: Administration of either ofloxacin 400 mg (2x200 mg) once daily for 5 days or an identical placebo. MAIN OUTCOME MEASURE: Vaginal loss, assessed using a pictorial chart. RESULTS: No significant difference in post-operative vaginal loss was found. CONCLUSION: Routine antibiotic prophylaxis after loop diathermy excision is not justified.