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Biomedical subjects

J Fodor

Publications and source records attributed to J Fodor.

At least 55 records · Page 3Linked to original sources
PubMed1988

Radiotherapy alone or in combination with surgery in the management of stage III breast cancer.

239 women with stage III carcinoma of the breast were treated by primary radiation therapy from 1977 to 1985. Of them 212 had an objective response and 27 showed no response to irradiation. From the objective responders, 105 patients were subjected to mastectomy and axillary dissection and in 107 cases the radiotherapy was not followed by surgery. Patients of operated group had a 71% and the RT alone group had a 61% local-regional tumor control at 5 years. The analysis of local-regional recurrences revealed that none of the operated patients had axillary recurrence but 8 had in the RT alone group. Postirradiation surgery is recommended for patients who have residual disease especially in the axillary region. The 5-year survival rate of operated patients was significantly better, 58% vs. 35%. However, these results are not comparable since the incidence of less favourable cases was higher in the RT alone group. Chemotherapy was initiated for the 27 patients who failed to respond to RT, but results were unsatisfactory. None of them survived three years. Further studies are needed to explore the role of chemotherapy in this stage of breast cancer.

Adult↗
PubMed1987

Prognostic significance of residual disease after radiation therapy of stage III breast cancer.

239 Consecutive women with stage III carcinoma of the breast were treated by primary radiation therapy (RT) from 1977 to 1985. The response rate was 89%, the 5-year survival 40% and the local-regional tumor control (LTC) 59%. For the 27 non-responders, postirradiation chemotherapy was initiated but they died within 3 years. 105 Patients were subjected to mastectomy and axillary dissection after RT. In 107 cases, the RT was not followed by surgery. Systemic treatment consisted of hormonal therapy in both groups. The RT plus surgery group had better survival rate, 58% vs. 35% at 5 years. However, the incidence of less favorable cases was higher in the RT alone group. Histological findings in the operated group are analysed to determine prognostic significance of residual disease. No residual or only damaged microscopic disease was found in the breast in 36% of the cases. The axillary lymph nodes (ALN) were free of disease in 42% of the women. Patients with negative ALN after RT had significantly better 5-year survival (82% vs. 43%) and LTC (85% vs. 60%) rates. Decreased chest wall recurrence rate was associated with no residual or damaged microscopic disease in the breast (5% vs. 21%). The disease-free ALN were more common after 50-80 Gy telecobalt than after 40-50 Gy kV irradiation (51% vs. 33%). Primary tumor size (phi less than 5 cm vs. phi greater than 5 cm) had no significant impact on histological findings or on prognosis. Residual disease is mainly a marker of tumor-host relationship which indicates the biological aggressiveness of the disease.

Adult↗
PubMed1987

Productivity monitoring of the non-technical staff.

Productivity monitoring of non-technical staff can be a difficult task for the manager, according to the authors. They suggest one method, work-sampling, which can be used effectively with this group, and describe its application in a radiation oncology department.

Efficiency↗
PubMed1984

Monitoring the iodine dose.

The administration of large amounts of iodinated contrast media can result in acute renal failure. Many diagnostic examinations, including pyelography, computed tomography and digital vascular imaging, require the injection of significant amounts of contrast media. Additionally, these examinations may be performed within 24-48 hours of each other, increasing the likelihood of a dose-induced acute renal failure. To avoid this complication, we have developed and implemented a system to monitor and control the patient's dose of iodine. This system effectively alerts individuals to the iodine dose the patient has received within the last 48 hours. The information is being used to compile a study concerning the relationship between iodine dose and the occurrence of acute renal failure.

Acute Kidney Injury↗
PubMed1984

Occupational injuries in radiology: strategies for cost containment.

Occupational injuries represent a measurable part of the operating costs in the health care environment. Injury rates in hospitals have been documented to be higher than those in industry; one possible cause may be the cost-based reimbursement setting which provides no incentive to reduce occupational injuries. With the advent of prospective payment, the costs associated with occupational injuries must be reduced. This paper will discuss the common hazards in radiology, as well as action that can potentially reduce these costs. Prospective payment has given a new meaning to cost containment, forcing the radiology administrator to seek all possible means to contain costs.

Accidents, Occupational↗
PubMed1983

The role of leukocytes in the serum acute-phase reaction accompanying inflammatory reactions.

The effects of whole-body X-irradiation with a dose of (7 Gray) were studied on the time course of systemic responses (fever, leukocytosis, serum coeruloplasmin concentration) in turpentine-induced inflammation and on the acute-phase reaction (coeruloplasmin, haptoglobin and seromucoid) produced by various stressful conditions (turpentine-abscess, immobilization, restraint conditions). Results showed that in the irradiated animals the lack of the leukocytic and febrile response to turpentine administration was accompanied by a normal coeruloplasmin response. Therefore, we have concluded to the involvement of more than one mediator in the development of systemic reactions accompanying inflammation. The leukopenia induced by whole-body irradiation could not prevent the development or reduce the magnitude of the acute-phase response in any of the models analysed. This observation appears to make doubtful the exclusive role of leukocytes in the mediation of the acute-phase reaction.

Animals↗
PubMed1980

Clinical trials with MTDQ /6,6'-methylene-bis (2,2,4-trimethyl-1,2-dihydroquinoline)/ an antioxidant with radiation sensitizing effect.

Daily doses of 1320 mg MTDQ have been administered orally to 7 patients for 100 subsequent days. Biological half-life and serum concentration measurements were performed. Function of vital organs, as well as routine laboratory findings revealed that MTDQ did not induce any toxic changes. The effect of MTDQ on the radiosensitivity of hypoxic tumor cells was studied in a combined treatment modality including 12 patients. The action on tumor regression was found encouraging. It has been found remarkable, too, that due to the effect of MTDQ and radiotherapy some of the nonspecific and general symptoms (e. g. pruritus) also disappeared.

Clinical Trials as Topic↗
PubMed1979

Basal cell carcinoma treated with MTDQ and irradiation.

Patients with basal cell carcinoma of the skin were treated with combined MTDQ (6,6'-methylene-bis-(2,2,4-trimethyl-1,2-dihydroquinoline)) administration and irradiation. Significantly better results were obtained with a skin exposure of 2 000 R combined with MTDQ than with the same dose alone. The results were comparable to those obtained with an exposure of 4 000 R. MTDQ administration induced decrease of tissular malonaldehyde concentration and suggested the peroxide-decomposing action of the radiation sensitizer.

Adult↗
PubMed1979

[Rapidly growing carcinoma of the penis].

After a brief review of the cancer of the penis the case of a 24-year-old man is described. After five months of the rapidly progressing cancer of the penis no radical operation could be performed in the intact tissue. The importance of biopsy is stressed which has to be repeated, occasionally involving the preparation of series of slides.

Adult↗
PubMed1976

Dose contribution to regional lymph nodes from gynecological remote afterloading cobalt-60 sources.

Dose contribution to the regional lymph nodes from high dose rate gynecological intracavitary technique was studied. For computer, calculating radiation dosage, rectangular lymphograms were taken. The average dose to point B and obturator nodes was nearly equal, 29-28% of point A dose. The common iliac nodes received the lowest dose, 14% of point A dose on the average. Due to the wide variation in the position of the uterus (deviation and dislocation), the dose at each of the two corresponding points or nodes (right and left side) was never equal. The effect of the uterus deviation and dislocation on the dose distribution was also studied in computer model display. We managed to describe this effect by an exponential curve. Because of the wide variation in the position of the uterus, only the individual dose calculation to the lymph nodes makes it possible to determine the most accurate amount of additional external irradiation.

Cobalt Radioisotopes↗
PubMed1976

Peripheral blood lymphocyte counts and survival in breast cancer.

The lymphocytes in the peripheral blood of patients with breast cancer were studied. Peripheral blood lymphocyte counts were found to be significantly lower in the short-survivors when compared with the long survivors. Lymphocyte count may be a host factor, that influences survival in breast cancer.

Breast Neoplasms↗