[A case of zinc deficiency during prolonged exclusively parenteral alimentation].
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Biomedical subjects
Publications and source records attributed to J Fogliani.
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The action of lipids on haemostasis has already been shown. The authors study possible changes of haemostasis induced by the use of a substance: Trive 1000 containing 3.8 g of Soya oil and 0.3 g of Soya lecithin per 100 ml. Twenty patient received 1 litre per day over a period of ten days and were compared with 16 controls receiving glucose and amino acides without lipids. Studies of haemostasis included: overall coagulation by the thrombo-elastogram, P.R.P. (platelet rich plasma), estimation of the co-factors of the prothrombin complex, thrombin and reptilase times, platelet count, platelet stickiness using the method of HELLEM, platelet aggregation using the method of Born, plasminogen and plasmin activity by the pH STAT method, and P.D.F. levels. These examinations were carried out on the 1st, 3rd, 5th, 7th and 9th postoperative days. The results in the patients receiving Trive 1000 were as follows: no change in blood coagulation, progressive fall in platelet activity in the sense of hypoaggregability which was significant from the 5th day onwards only. There was no change in fibrinolysis. By contrast, there was anaemia, as determined on the basis of a fall in haematocrit, maximal on the 5th day and attributed by the authors to the haemolytic properties of triglycerides. In conclusion, Trive 1000 had no signifcant influence on haemostasis, apart from platelet hypoaggregability of moderate degree after prolonged treatment and perhaps haemolytic anaemia.
The authors define the management of a patient following emergency admission for the ingestion of a caustic liquid: immediate assessment by fibroscope oesophagoscopy; avoidance of all corticosteroid therapy and of the insertion of a gastric tube; parenteral alimentation. The frequency of early deaths has considerably decreased since the applications of this method, either as a result of shock or of the inhalation of caustic liquid.
The authors report the results of 26 oesophagoplasties carried out using the descending colon for oesophageal stenosis as a result of a caustic lesion. Superior: in 5 cases the anastomosis being made to the pharynx. Inferior: 8 associated gastric lesions being treated either by resection or by short circuit. The remaining oesophagus was removed in two cases. There were two postoperative deaths. In all the remaining patients a satisfactory functional result was obtained.
Given the poor prognosis in carcinoma of the oesophagus, and with the aid of advances in anaesthesia and postoperative care, surgery has progressively evolved towards wider excision and a reduction in the number of operative stages. Partial oesophagectomy, with gastrolysis and gastro-oesophageal anastomosis, via a left thoracotomy, is favoured by large number of authors. However, it involves a certain number of disadvantages: by definition a limited excision, unsuitable for carcinomas in the cervical region and a marked risk of postoperative gastro-oesophageal reflux. Total oesophagectomy offers a hope of better results from an oncological standpoint, the more so since excision may be extended superiorly (laryngectomy) or inferiorly (total gastrectomy with lymph node excision). Continuity is re-established using a colonic transplant. The operation may be performed in two stages, though a single stage procedure with two teams would appear to be preferable, overall mortality and morbidity being reduced. Finally, colonic oesophagoplasty may be used alone, as a simply palliative measure, without associated tumour excision. By short-circuiting the oesophageal stenosis, it permits continued alimentation per os and the patient's period of survival is more comfortable.
Pre-operative assessment of a patient suffering from a carcinoma of the oesophagus demonstrates numerous pathological features and marked malnutrition. The authors give details of their method of nutritional preparation: operation is scheduled only when the patients are restored to a state of anabolism, i.e. when daily potassium balance is greater than 40 mEq and daily nitrogen balance exceeds 4 g. Carolies are provided either intravenously or via a gastric tube. Alimentation consists on average of 2,000 to 2,6000 calories as carbohydrate and lipids and 12 to 14 g of nitrogen. This preparation lasts on average for one week. It is associated with a reduction in mortality and the number of postoperative complications.
In a study involving 217 patients who had undergone thoracotomy, the authors noted 85 complications in 77 patients with a mortality of 2.5 per cent. Respiratory complications were the most common but never ended in death. By contrast, cardiac complications are the most severe. The absence of mortality of respiratory origin is certainly the result of regourous pre-operative selection based upon overall and separate pulmonary function studies. The great rarity of pulmonary embolism is related to routine postoperative preventive heparin therapy.
The authors recall the symptoms of peroperative and early postoperative bronchospasm. They emphasise the etiology and the treatment. In fact, bronchospasm may be induced by several causes:--mechanical or chemical vagal stimulation;--direct or allergic-induced histamine liberation, induced by certain drugs (mainly curare);--taking beta-blockaders before operation, favoured by the use of morphine during operation;--finally, any irritation of the bronchi (inhalation of gastric juice, pulmonary embolism, pulmonary oedemal). The treatment is etiological but also symptomatic:--enrich the inspired air with oxygen;--inject I.V. 1/2 to 1mg of atropine;--in case of failure, one should use Salbutamol I.V. which is very effective during contraction of the bronchial muscles;--massive corticosteroid therapy will be effective in mucosal oedema.
The authors report 36 cases of resection and suture for stenosis or tumour of the trachea and give details of their technique of anaesthesia, the post-operative follow-up and their results. The development of fiber endoscopy and simplification of intubation, increases the security of the patient, facilitates the task of the anaesthetist and thus improves greatly the operative conditions and post-operative period.
Among 109 subjects who had undergone cardiac surgery under ECC, the authors recorded 50 (45 p. 100) who suffered from shivering during the coming round period. Comparing the series of patients who shivered, with that of the subjects who did not shiver, the authors demonstrate in the first case, an increase in cellular metabolism, the cardiac index, heart rate, central venous pressure and cardiac work. They subsequently note the apprearance of mixed acidosis and an increase in the lactate-pyruvate ratio. Certain patients, in whom the cardiac output did not keep up with the metabolic demand considerably increased the arterio-venous oxygen difference. Blood loss is increased as well as coagulation time showing a more intense heparin rebound. The study of the drugs used during anesthesia showed that the patients who had received chlorprotixene, as the neuroleptic, a neuroleptic with adrenolytic properties, had a very decreased frequency of shivering in comparison with those who had received droperidol. The placing of the patient at the end of the intervention on a heating mattress, combined with the administration of chlorprotixene during anesthesia, prevented the appearance of shivering.
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The authors present 29 cases of post-operative respiratory complications in abdominal surgery in subjects without any past history of respiratory disorders. They stress the diagnostic value of these cases of acute respiratory failure shown in a third of the cases of surgical complications.
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Seven patients presenting a state of shock were treated with dopamine. The authors remark an undeniable effect on arterial pressure which rises again and on the diuresis.
The authors report two cases of artificial ventilation with the assistance of a membrane oxygenator that was used, on the one hand, in the case of a 'malignant pneumopathy' and, on the other hand, in the case of a cardio-respiratory failure after a complete mending of a tetralogy of Fallot. Recovery was obtained in the second case. They specify the method and the watching of anti-coagulation. They insist upon the merit of a re-injection of oxygenated blood into the ascending aorta. They recall the necessity to lay down instructions according to very strict criteria, by taking into account the degree and the visceral repercussions of hypoxia and the reversibility of lung lesions in so far as it is a matter of a very heavy palliative therapy upon whose efficiency it is difficult to pass a judgment.
A great number of congenital heart diseases are now amenable to treatment before school age. A homogeneous experience of 158 cases operated upon made it possible to make the follow remarks:--The operative mortality before the age of 1 year remains high, in view of the difficulties of ressuscitation, but mainly because of the severity of the heart disease to treat. --Between the ages of 1 and 5 years, the risk decreased with experience, and for the heart diseases most frequently encountered, lethality fell to 2.8% for the last 4 years. One may thus accept to perform, not only necessity operations, but principle operations before school age. The schematic indications in relation with each heart disease were analysed.
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