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Biomedical subjects

J Follana

Publications and source records attributed to J Follana.

11 recordsLinked to original sources
PubMed1999

Prevalence of GBV C/HGV RNA and GBV C/HGV antibodies in French volunteer blood donors: results of a collaborative study.

BACKGROUND AND OBJECTIVES: Posttransfusion hepatitis still occurs at an incidence of about 1 in 118,000 for HBV and 1 in 220,000 for HCV. This collaborative study aimed to determine the prevalence of a novel flavivirus, GBV-C/HGV, even though its role in transfusion-associated hepatitis is uncertain. MATERIALS AND METHODS: GBV-C/HGV RNA was detected by PCR using either the Boehringer detection kit or by primers previously described. HGV antibodies were detected by a serological assay from Boehringer. RESULTS: The observed GBV-C/HGV RNA frequency was 3.4%. HGV antibodies occurred in 9.5% of donors. CONCLUSION: In our study, 12. 9% of the donors had been in contact with the GBV-C/HGV virus.

Adolescent↗
PubMed1990

Skin necrosis after injection of aminosides. Arthus reaction, local toxicity, thrombotic process or pathergy?

A case of extensive skin necrosis following intramuscular injections of sisomycin is described. Eight cases of necrosis following subcutaneous injections of aminoside antibiotics have been reported in elderly females under anticoagulant theray, but the pathogenic mechanisms of these lesions have not been investigated. Defective fibrinolysis and abnormalities of oxidative metabolism of neutrophils were noted in our patient. Four major mechanisms are discussed: an Arthus reaction, a thrombotic process, a direct toxicity of aminosides for subcutaneous tissue, or a pyoderma-like neutrophilic reaction. Subjects with a tendency to thrombosis and/or abnormalities of neutrophil functions may be predisposed to these skin necroses.

Arthus Reaction↗
PubMed1980

[Perforating generalized granuloma annulare. A two case study (author's transl)].

This article deals with two new cases of perforating generalized granuloma annulare characterized, from a clinical and biological standpoint, by a long course of evolution for one case and the presence of diabetes and dyslipidemia for the other case. Histologic study confirms the possible coexistence of typical granuloma annulare lesions with epidermic corbelar aspects pinching necrotic material which could lead to complete epidermic perforation. Based on the study of previous cases in the literature, the process of transepidermic elimination and the actual pathophysiologic concepts of granuloma annulare are reviewed. From the therapeutic standpoint, if the first case did not appear to profit from the administration of an alkylating agent, the second case seems to be presently improved through gluco-lipid re-equilibrium associated with lipocaic heparin.

Aged↗
PubMed1978

[Cutaneous periarteritis nodosa. Critical study about 4 cases (author's transl)].

Cutaneous form of periarteritis nodosa. Four personal cases are added to 70 cases of the previous literature. The clinical and biological picture of the cutaneous form of P.A.N. are different from the systemic one by the lack of visceral involvement and a noteworthy good long-term prognosis. Venous (superficial thrombophlebitis) and distal arterial involvement in some cases, raise doubts about diagnosis and classification. The solution is in an accurate definition of the diagnostic clues and specially of the histopathological ones.

Adult↗
PubMed1976

[Infantile digital fibromatosis. Anatomo-clinical and ultrastructural study].

About one personal case, authors consider clinical, histological and ultrastructural aspects of the infantile digital fibromatosis. They insist on the caracteristic features of the large granular and fibrillar cytoplasmic inclusions observed in the proliferative fibroblasts, and on the different signs of the metabolic hyperactivity of these cells. Elastogenesis was very scarce within the swelling but showed no evidence of qualitative abnormality. The discussion provides no definitive clue as to the nature or origin of the inclusions.

Female↗
PubMedDate not supplied

[Self-healing juvenile cutaneous mucinosis. Clinical, histological and ultrastructural study (author's transl)].

Referring to two other cases reported in the literature, the authors suggest the individualisation of a new form of cutaneous mucinosis which is characterized:--clinically, by the young age of the patient, the peculiar topography of the eruption extending to the face, neck, scalp, abdomen and thighs and the association to deep nodules of the face and the periarticular regions;--biologically by the absence of inflammation, dysglobulinemia, endocrinologic changes or bone marrow plasmocytosis;--by the acute on set of the lesions with spontaneous resolution within a few weeks. The diagnosis is based on histologic and histochemical criteria. The mucinous change occurs in the reticular dermis. Ultrastructural features are similar to those found in other dermal mucinoses. The deposit appears to be composed of an electron lucent matrix containing a micro fibrillar network, probably of polysaccharidic nature. In spite of the histochemical similarity to epithelial mucins, the biochemical composition and mode of production of the deposited substance remain to be elucidated.

Adolescent↗