Biomedical subjects
Publications and source records attributed to J Forejt.
The distribution of HLA phenotypes, gene and haplotype frequencies was studied in three Mongoloid populations in Central Asia (Tofs, Tuvinians and Buryats). In comparison with Caucasian populations increased frequency of HLA-A9, BW40 and BW15 and haplotype A9, BW15 as well as low frequency of HLA-A1, B8 and B12 are characteristic of all three populations. Buryats seem to have the relatively highest admixture of Caucasoid genes.
A hypothesis suggesting an evolutionary significance of centromeric heterochromatin polymorphism, which presumed the suppression of genetic crossing-over in the paracentromeric chromosome regions, was experimentally tested. The data obtained do not support the hypothesis; the frequency of paracentromeric chiasmata in two inbred mouse strains (differing in centromeric heterochromatin pattern) is not higher than in their F-1 hybrids. C-bands staining of centromeric heterochromatin allowed the distinction of two types of paracentromeric chiasmata. One of them--pseudochiasmata--is probably the consequence of centromeric heterochromatin affinity rather than the result of the preceding crossing-over.
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