PubMed Health⌕ Search

Biomedical subjects

J Fort

Publications and source records attributed to J Fort.

At least 37 records · Page 2Linked to original sources
PubMed1995

Serum lipoprotein (a) levels in patients with chronic renal failure--evolution after renal transplantation and relationship with other parameters of lipoprotein metabolism: a prospective study.

In order to analyze the relationship between lipoprotein (a) [Lp (a)] and other lipoproteins during chronic renal failure and once renal function is restored after kidney transplantation, we determined the serum levels of total lipoprotein, high-density lipoprotein, low-density lipoprotein, and very-low-density lipoprotein cholesterols, total and very-low-density lipoprotein triglycerides, apolipoproteins A-I, B, C-II, C-III, and E, and E, and Lp (a) in 30 patients with chronic renal failure before and 12 months after renal transplantation. During the 1st year after transplantation, all patients were treated only with ciclosporin and prednisone and had serum creatinine levels < 1.6 mg/dl (140 mumol/l) and proteinuria < 500 mg/day. No patients had chronic hepatic disease. To determine reference values we studied a control group of 60 healthy volunteers. Before renal transplantation, the study group showed higher concentrations of triglycerides, very-low-density triglycerides, very-low density lipoprotein cholesterol, apolipoproteins, C-II and C-III, and Lp(a) than the control group. There was no correlation between Lp(a) and any of the studied variables. After renal transplantation, the serum levels of total lipoprotein, high-density lipoprotein, and low-density lipoprotein and apolipoproteins A-I and B increased significantly. Apolipoproteins C-II and C-III and Lp(a) decreased and normalized. After these changes had taken place, there was no relationship between Lp(a) and other parameters of lipoprotein metabolism. We conclude that the increase in Lp(a) during the chronic renal failure phase is basically related to the loss of renal function and does not depend on the resultant alterations which are produced in other lipoprotein variables.

Adult↗
PubMed1995

Cost-effectiveness of MR imaging in evaluating polymyositis.

OBJECTIVE: Polymyositis is an inflammatory disorder of muscle that is often difficult to diagnose. The purpose of this study was to assess the usefulness and cost-effectiveness of MR imaging as a biopsy guide in patients with suspected polymyositis as an alternative to a blind biopsy. SUBJECTS AND METHODS: Our subjects were 25 patients with clinically suspected and ultimately confirmed polymyositis, 14 of whom had preoperative MR imaging at 1.5 T (including axial T1-weighted, axial T2-weighted [fat saturated], coronal T1-weighted, and coronal fast short-T1 inversion recovery images of both entire extremities). Images were prospectively interpreted for a specific location for a biopsy that showed the most muscle edema with the least atrophy. Surgical results and the estimated true cost of medical care (cost-accounting method) were compared between patients with preoperative MR images and patients whose biopsy site was selected on the basis of clinical criteria. RESULTS: Among the 14 patients whose biopsy site was selected on the basis of MR findings, only one biopsy result was false-negative. Patients without imaging had five biopsies with false-negative results. Patients with preoperative MR images averaged actual medical costs of $14,000 compared with $20,000 for those without MR images. Hospitalization time averaged 12 days for patients with MR images for guidance compared with 14 days for those without MR images. The average daily cost was $1,150 for the patients with MR images compared with $1,390 for those without. CONCLUSION: We conclude that MR imaging not only can aid in surgical planning but also can decrease the costs of patient care for patients with suspected polymyositis.

Adult↗
PubMed1989

[Pulmonary hemorrhage and glomerulonephritis associated with essential mixed cryoglobulinemia].

A 49-year-old male with essential mixed cryoglobulinemia IgM kappa-IgG of 4-years duration was treated with corticosteroids and immunosuppressive drugs during the repeated episodes. Finally, he developed a new episode with severe renal involvement and pulmonary hemorrhage without other associated etiological factors. The optical and immunofluorescent histological findings in lung and kidney are described. This is the second case of pulmonary hemorrhage and cryoglobulinemia associated with essential mixed cryoglobulinemia reported in the literature. A relation between essential mixed cryoglobulinemia and glomerulonephritis and pulmonary hemorrhage is suggested.

Cryoglobulinemia↗
PubMed1989

[Acute interstitial secondary to tricuspid endocarditis caused by Staphylococcus aureus].

The kidney diseases in patients with bacterial endocarditis and intravenous drug addicts (IVDA) tend to be of glomerular origin. Interstitial nephritis has been related to drug toxicity and only occasionally has it been described in other associations. We describe a 27-year-old patient IVDA with tricuspid endocarditis caused by S. Aureus whose first manifestations was acute renal failure. The renal biopsy showed an interstitial nephritis. It was treated with antibiotic and hemodialysis, obtaining the cure and normal levels of plasmatic creatinine.

Acute Disease↗
PubMed1988

False positive ELISA tests for anticardiolipin antibodies in sera from patients with repeated abortion, rheumatologic disorders and primary biliary cirrhosis: correlation with elevated polyclonal IgM and implications for patients with repeated abortion.

Non-specific binding in an ELISA test for antibodies to cardiolipin (ACA) was investigated in sera from patients with primary biliary cirrhosis, rheumatological disorders, and repeated abortion. Binding to wells without phospholipid was most frequent in ELISA assay for IgM class ACA and correlated with levels of serum polyclonal IgM in patients with repeated abortion and rheumatologic disorders (r = 0.79, 0.76). Using added polyclonal IgM we demonstrated that the increase in non-specific binding was most significant when levels of ACA were low; subtraction of binding to the unoccupied well over-corrected specific antibody estimates when a high affinity antibody was present. Absorption studies on three sera suggest that this 'non-specific' binding includes low affinity antibody binding. Elevated levels of polyclonal IgM in sera from patients with repeated abortion may account for some reports of elevated IgM class antibodies in other ELISA assays. The prevalence of a positive test for ACA in a sequential series of 412 such patients was reduced to 6.1% (95% confidence limits 4-9%) after subtraction of non-specific binding.

Abortion, Habitual↗