PubMed Health⌕ Search

Biomedical subjects

J Forty

Publications and source records attributed to J Forty.

At least 37 records · Page 2Linked to original sources

Videothoracoscopy in the diagnosis of intrathoracic pathology: early experience.

We report our experience using the new technique of videothoracoscopy in the diagnosis of intrathoracic pathology. In the last 12 months, 40 patients (24 male; 16 female) have undergone investigation by this method. Lung biopsy has been performed in 17 patients, pleural biopsy in 20 patients and mediastinal biopsy in three patients. The majority had been referred after other investigations had been inconclusive. All biopsies were diagnostic except one mediastinal biopsy. This early experience suggests that videothoracoscopic biopsy is a well-tolerated technique with high diagnostic yield.

Adolescent↗

A technique for perfusion of an isolated working heart to investigate hyperacute discordant xenograft rejection.

We developed an isolated working heart preparation to investigate hyperacute rejection of discordant xenografts. It is possible to correlate organ failure with the rejection process, and end points of rejection are easily identified. This unique model permits easy sampling of perfusates and examination of the rejected organ. The perfusate may be modified in ways not possible in in vivo preparations. Investigation of the discordant rabbit-to-pig combination with the technique has confirmed that hyperacute xenograft rejection can be reproduced. Rejection appears to be a complement-mediated immunologic phenomenon rather than the consequence of a nonspecific physical incompatibility. Hyperacute xenograft rejection can be prevented by depletion of C3 from the perfusing blood by treatment with cobra venom factor.

Animals↗

Videothoracoscopy in the treatment of spontaneous pneumothorax: an initial experience.

We report an initial experience with the new and potentially advantageous technique of videothoracoscopy in the treatment of pneumothorax. A series of 18 consecutive patients (14 male, 4 female) presenting with spontaneous pneumothorax over a 4-month period underwent surgical treatment by this method. The indication for surgery was recurrent pneumothorax in nine patients and persistent air leak in the remainder (median duration 15 days, range 5-28 days). Stapled apical bullectomy with apical parietal pleurectomy was performed in 14 patients, bullectomy alone was performed in one patient and pleurectomy alone in three patients. Additional talc pleurodesis was carried out in three of these patients. Median duration of operation was 53.5 min (range 35-120 min). The median postoperative drainage was 300 ml in 24 h (range 50-580 ml). The median duration of intercostal drainage was 48 h (range 24-384 h) and of postoperative hospital stay 4 days (range 3-18 days). The mean postoperative analgesic requirement was 1.3 mg morphine/h. Three complications required reoperation. In two patients a large air leak persisted after operation; one proceeded to thoracotomy for suturing of the air leak and in the other this was accomplished by videothoracoscopy. A further patient re-presented at 2 weeks with recurrent pneumothorax which was treated at thoracotomy. At a median follow-up of 68.5 days (range 10-124 days) this is the only recurrence. These complications were caused by errors in surgical technique early in our series. This initial experience of videothoracoscopic pleurectomy suggests it is an effective, well-tolerated treatment of spontaneous pneumothorax.

Adolescent↗

Perfusion of rabbit hearts with human blood results in immediate graft thrombosis, a temporally distinct component of hyperacute rejection.

Hyperacute discordant xenograft rejection can be simulated by a blood-perfused working isolated heart. The survival of the heart is dependent on its functional integrity, and the preparation is thus sensitive to early myocardial damage. Perfusion of rabbit hearts with human blood produces immediate graft destruction by a thrombotic process which is a distinct component of hyperacute rejection.

Acute Disease↗

Activation of the alternative pathway of complement is an important component of hyperacute rejection of rabbit hearts by human blood.

Hyperacute discordant xenograft rejection can be simulated by blood perfused working isolated heart. The survival of the heart is dependent on its functional integrity, and the preparation is thus sensitive to early myocardial damage. Perfusion of rabbit hearts with human blood results in immediate graft destruction by a thrombotic process. Prevention of this process results in rapid rejection at about 20 min by the alternative pathway of complement.

ABO Blood-Group System↗

Inhibition of rejection of hamster-to-rat heart xenografts.

Prolonged survival of concordant organ xenografts as typified by hamster-to-rat heart transplants is difficult to produce. Studies have revealed that T cells are not primarily involved in rejecting such xenografts and that the rat recipients produce high titres of lytic anti-hamster antibodies. In this study, 200 hamster-to-rat cardiac xenografts performed in 30 different experiments revealed that cyclophosphamide (CyP) and cyclosporin A (CyA) could inhibit this antibody production. CyP alone was relatively ineffective in prolonging graft survival (the median survival time was 14 days versus 3 days in untreated controls). Combining CyP and CyA virtually abolished rejection in this model. Four critically timed doses of CyP combined with continuous CyA resulted in recipients not producing anti-hamster antibodies, despite cessation of CyP therapy, and prolonged graft survival time (median survival time was more than 100 days). Cessation of CyA at 60 and 100 days resulted in the rejection of the xenografts and the appearance of the rat anti-hamster antibodies. Xenografts in recipients given only one or two doses of CyP (and continuous CyA) had a median survival time of 7 and 12 days respectively. However xenograft rejection in rats given only 1 or 2 doses of CyP could be averted by complement depletion using a 3-week course of cobra venom factor (CoF) starting on day 4 or day 7 post-transplantation respectively. Discontinuation of CoF after 3 weeks did not result in graft rejection. These results showed that immunosuppressive therapies directed at inhibiting antibody production may be of value in preventing rejection of concordant xenografts. Short-term complement depletion could rescue xenografts from rejection such that rescued grafts appear to be accommodated.

Animals↗

Perfusion of rabbit hearts with pig blood results in complement mediated hyperacute xenograft rejection.

Investigation of hyperacute rejection of discordant xenografts has been hampered by the lack of a model for the study of rapid time course events. In vivo models are unsuitable for observation of early rejection processes and, along with most ex-vivo perfusion preparations, are insensitive since no functional demand is placed on the organ which may have undergone extensive damage whilst still appearing viable. For this reason a blood perfused isolated working heart preparation has been developed. With left atrial and left ventricular loading the heart performs measurable work as it ejects into a mock circulation with both afterload and compliance components. When cardiac function is compromised the heart is no longer able to eject against the fixed afterload and both cardiac output and coronary circulation cease with resultant organ failure. The model is thus highly sensitive to minimal organ damage and has an easily identifiable endpoint. In the present study, we used this preparation to study the discordant species combination of rabbit hearts perfused with pig blood.

Animals↗

Traumatic intercostal pulmonary hernia.

Traumatic intercostal pulmonary hernia is a rare sequel to injury, especially in children and where there is no penetrating wound. Spontaneous regression of these hernias has been reported and conservative management has been advocated. We describe a case in which a smooth-walled intercostal defect and lung hernia that did not regress developed in a child. This was successfully repaired with a Gore-Tex (expanded polytetrafluoroethylene) patch. Repair is advisable in such cases, but operation can be delayed to allow possible resolution.

Adolescent↗

Empyema thoracis: a review of a 4 1/2 year experience of cases requiring surgical treatment.

During the period January 1985 to June 1989, 53 cases of empyema thoracis were treated surgically at Papworth hospital regional cardio-thoracic centre. Of these, 47 patients underwent thoracotomy and decortication as their primary surgical treatment. The remaining six patients were treated by rib resection. Prior to surgical referral 20 of these had undergone previous tube drainage for a mean period of 18 days (range 7-42 days). The principle cause of empyema was broncho-pulmonary infection. In 57% of cases no organisms were isolated from pleural debris or fluid. In the remainder, a variety of organisms were encountered. Early surgical drainage and freeing of the underlying lung met with good results and no deaths in the uncomplicated group. The median duration of postoperative chest drainage for the whole group was 7 days (mean 12 days) and median postoperative in-hospital stay was 13 days (mean 20 days). This is in stark contrast to the duration of hospitalization of patients prior to surgical referral (mean 103.6 days). There were five deaths. All occurred in patients with severe debilitating associated illnesses. In these patients initial drainage of the empyema space with a tube or by rib resection may have allowed recovery prior to more major surgery.

Adolescent↗

The functional result of pelvic ileal reservoir in 10 patients with familial adenomatous polyposis.

Ten patients with familial adenomatous polyposis (FAP) were treated by total colectomy, mucosal protectomy and ileoanal anastomosis with a pelvic ileal reservoir. The functional results were assessed by means of a patient questionnaire and suggested that this operation may represent the ideal treatment for the condition, irradicating disease-bearing mucosa, avoiding an ileostomy and providing acceptable function.

Adenomatous Polyposis Coli↗

Comparison of stapling and hand-suture for left-sided large bowel anastomosis.

One hundred patients undergoing elective left-sided colonic or rectal resections were randomly allocated to have an anastomosis performed either with the EEA stapling gun or by hand suture using a single layer of interrupted sutures. In six patients the anastomosis could not be performed with the stapling gun. Clinical leakage occurred in two of the remaining 94 cases; both had hand-sutured anastomoses. Radiological leakage was demonstrated in 13 further cases (7 stapled, 6 sutured); there was no statistical difference in leakage rate with stapled and hand-sutured anastomoses.

Adult↗

Initial impressions of dazoxiben in the treatment of the ischaemic limb.

1 Dazoxiben, a selective thromboxane synthetase inhibitor, which is active after oral administration, has been used to treat eight patients with severe peripheral vascular disease associated with ischaemic rest pain. 2 Patients were selected for treatment on the basis that amputation was the only alternative procedure. 3 Three of eight patients are well and pain-free 1, 7 and 11 months after initially receiving the drug and have not required amputation. 4 Dazoxiben may prove useful in the treatment of peripheral vascular disease.

Adult↗