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Biomedical subjects

J Foster

Publications and source records attributed to J Foster.

At least 55 records · Page 3Linked to original sources
PubMed1991

Teenagers and alcohol: results of a Scottish national survey.

During 1990 a survey was conducted of the self-reported drinking habits and alcohol-related knowledge and beliefs of a national sample of 7009 Scottish teenagers. The study group were age 14-16. Results indicated that only 3% of respondents had never consumed alcohol. The great majority of teenagers reported consuming only moderate quantities of alcohol. Even so 18.9% of males and 10.3% of females reported consuming 11 or more units on their last drinking occasion. The proportion of teenagers classified as 'heavy drinkers' increased markedly between the ages of 14 and 16. This study confirmed earlier findings indicating that Scottish teenagers are more likely than those in England to drink heavily and rather less frequently.

Adolescent↗
PubMed1991

The construction and selection of predictive scales, with special reference to parasuicide.

Issues concerning the use of predictive and screening instruments include the difficulties posed by temporal changes in the base rates for the behaviour of interest, the possible advantages of using three rather than the customary two risk categories, and the desirability of specifying in advance the proportional sizes of the risk subgroups. A method is proposed for constructing and assessing tripartite risk scales, and a new scale for predicting the repetition of parasuicide, with the results of a prospective validation study, is reported.

Adult↗
PubMed1990

The identification of psychiatric disorders in children who fail to attend school: a cluster analysis of a non-clinical population.

Interviews were conducted with parents of 100 children taken to a 'school attendance committee', because of persistent failure to attend school. Clinical assessment of the attendance problem was carried out so that children were categorized as 'school refusers' (N = 24), 'truants' (N = 53), 'both refusers and truants' (N = 9), or as 'neither' (N = 14). Any ICD-9 psychiatric disorder was separately identified. Cluster analysis of information collected in a standard way indicated that there was a group of children with the features of 'school refusal' who often had generalized neurotic disorders as well and who were mostly girls, another group with the features of 'truancy' all of whom had conduct disorders who were mainly boys, and a third cluster of children who were usually 'truants' but less often psychiatrically disturbed. The study provided evidence for the existence of school refusal with and without generalized neurotic disturbance in a non-clinical population.

Absenteeism↗
PubMed1990

Young people and drinking: results of an English national survey.

An account is presented of a survey of self-reported drinking habits and beliefs about alcohol amongst a national sample of teenagers in England. Fieldwork was conducted during 1988 and 1989 and involved 27 systematically selected state secondary (high) schools. Respondents were virtually all aged 14-16. The majority of teenagers reported drinking only moderate amounts of alcohol. Even so, a third of the males and nearly a fifth of the females reported having at some time consumed the equivalent of five and a half pints of beer on a single occasion. Factual knowledge about alcohol was not high and more than half of the study group supported a reduction in the legal minimum age at which alcohol may be purchased in licensed premises.

Adolescent↗
PubMed1990

Teenage heavy drinkers: alcohol-related knowledge, beliefs, experiences, motivation and the social context of drinking.

During 1988 and 1989 a survey was conducted of the drinking habits and alcohol-related beliefs of a national sample of teenagers in England. Data were obtained from 6,244 respondents virtually all aged 14-16. Heavy drinkers were significantly more likely to report drinking in a mixed sex group than were other teenagers. They were also more likely than others to have drunk illegally in licensed premises, and were distinctive from other teenagers in relation to their self-reported reasons for drinking and their alcohol-related beliefs.

Adolescent↗
PubMed1990

Identification of human acrosomal antigen SP-10 in primates and pigs.

The intra-acrosomal human sperm protein SP-10 was previously designated a "primary vaccine candidate" by a World Health Organization Taskforce on Contraceptive Vaccines. In the present study, a monoclonal antibody to SP-10 (MHS-10) was employed on Western blots to identify immunoreactive SP-10 in sperm extracts from baboon (Papio cyanocephalus anubis) and two macaques (Macaca mulatta and Macaca fascicularis). In each of these primates, the MHS-10 monoclonal antibody recognized a polymorphic pattern of immunoreactive peptides similar to that in humans. Immunoreactive SP-10 was also demonstrated in pig sperm. Using purified preparations of the previously described intra-acrosomal molecules acrosin and sperminogen in the pig, we observed that the MHS-10 monoclonal antibody did not react with these proteins, indicating SP-10 is distinct from these known acrosomal components. Sperm from several common species including the rabbit, bull, rat, guinea pig and cat did not immunoreact with the MHS-10 monoclonal antibody. By use of a radioactive probe spanning 628 nucleotides of the open reading frame for SP-10 on Northern blots of poly A + RNA obtained from testes of Macaca fascicularis, Papio papio, and Papio cyanocephalus anubis, a 1.35-kb mRNA of identical size to the mRNA from human testes was identified. These results indicate that baboons, macaques, and pigs may be appropriate models for testing an SP-10-based contraceptive vaccine.

Acrosome↗
PubMed1990

Impact of asymptomatic congenital cytomegalovirus infection on size at birth and gestational duration.

Cytomegalovirus (CMV) is the most common viral agent causing congenital infection in humans, affecting 0.2 to 2.4% of all live births. Symptomatic congenital CMV infection has previously been shown to cause low birth weight and prematurity. Whether or not asymptomatic congenital CMV infection, which represents the majority of cases (90 to 95%), affects intrauterine growth or gestational duration is unknown. Using a population of 146 infants with asymptomatic congenital CMV infection and 1419 controls from two socioeconomically diverse populations (biracial low income and white mid- to upper income), determinants of body size (birth weight and crown-heel length) were investigated using multiple regression techniques. We found that congenital infection following the transmission of maternal primary and "unknown" CMV infection resulted in a significant mean birth weight deficit of 163 g (P less than 0.04) for the low income term infants (blacks and whites), but not in the mid- to upper income white infants. Newborns with congenital infection following the transmission of maternal reactivated (recurrent) CMV infection were significantly shorter by a mean of 1 cm (P less than 0.03) than controls, a finding that was consistent regardless of socioeconomic status or race.

Birth Weight↗
PubMed1990

Medical indications and contraindications for eye donation.

Potentially useful and valuable donor-eye tissue is lost because physicians decide erroneously that certain deceased people are not suitable donors. The Indiana Lions Eye Bank Inc. needs and will receive with gratitude any and all donated eyes. Donated ocular tissue can be used for research or teaching, if not for actual transplantation. All deceased people should be regarded as suitable eye donors, except when the cause of death or other factors might pose risks for enucleators themselves.

Contraindications↗
PubMed1989

Cellular mechanisms of toxicity and tolerance in the copper-loaded rat. II. Pathogenesis of copper toxicity in the liver.

The distribution of copper has been studied in the liver of the copper-loaded rat at the ultrastructural level by X-ray electron probe microanalysis in order to clarify the pathogenesis of copper-induced damage. Male rats fed a high copper diet (1500 ppm) for 16 weeks were killed at intervals; their livers were removed and fixed in 4% paraformaldehyde and 2% glutaraldehyde for electron microscopy and were analyzed for copper by AA spectrophotometry. Three different forms of lysosomes were identified with respect to their morphology and X-ray emission profiles: Type I lysosomes appeared early and contained iron and zinc in addition to markedly elevated copper peaks, whereas later appearing Type II lysosomes included sulfur and phosphorus in addition to copper. Type III lysosomes were associated with the recovery period and contained much reduced elemental residue. Degenerative changes were not observed in any of the three types of lysosomes. Copper and other elemental residues, including sulfur, were also identified within the hepatic parenchymal cell nuclei and by contrast were associated with irreversible nuclear damage. Nuclear copper is directly injurious to this organelle and responsible for the subsequent cell death whereas copper contained within lysosomes is apparently innocuous.

Animals↗
PubMed1989

The neuroteratogenicity of procarbazine hydrochloride in the rat: histopathological and immunocytochemical aspects.

Procarbazine hydrochloride, and antineoplastic drug, was administered to pregnant rats from days 13 to 16 of gestation at doses of 0, 1, 5 and 15 mg per kg as part of a behavioural study. Histological examination of the brains from the offspring at 12 to 15 weeks of age revealed cerebral atrophy, which increased in severity with increasing dose, together with a reduction in neuronal numbers, with no apparent effect upon the astrocyte and oligodendrocyte populations.

Abnormalities, Drug-Induced↗
PubMed1989

Comparative study of early-season prophylaxis using ivermectin with lungworm vaccination in the control of parasitic bronchitis and gastroenteritis in cattle.

Twenty-four first-season calves were randomly allocated to three similar groups (1-non-treated controls; 2 - vaccinated against lungworm; 3 - treated with ivermectin 21, 56 and 91 days after turnout) and set-stocked on separate pastures. Parasitic bronchitis became evident in the controls and signs of parasitic gastroenteritis were seen later in the vaccinates, but the ivermectin-treated calves remained healthy. After autumn housing, all were kept as a single group for the winter. The following summer, six of the ivermectin-treated animals and their matching vaccinates were grazed together, without further prophylaxis, along with six first-season calves. The latter displayed evidence of mild but debilitating pulmonary and gastrointestinal parasitic disease while both groups of yearlings remained healthy (with the exception of one diarrhoeic vaccinate). Thus, the immune status of the ivermectin-treated animals appeared to be comparable to that of the vaccinates. This conclusion was supported by parasitological observations and by artificial challenge at the end of the second grazing season.

Animals↗
PubMed1989

Cellular mechanisms of toxicity and tolerance in the copper-loaded rat. III. Ultrastructural changes and copper localization in the kidney.

The distribution of copper and related changes have been studied in copper-loaded rat kidneys at the ultrastructural level by X-ray electron probe microanalysis, in order to clarify the pathogenesis of copper-induced damage and subsequent recovery in this organ. Male rats fed a high copper diet (1500 ppm) for 16 weeks were killed at intervals; their kidneys were removed and portions of kidney cortex fixed in 4% paraformaldehyde and 2% glutaraldehyde for electron microscopy: other samples were analysed for copper by AA spectrophotometry. Increasing copper accumulation was associated with progressive PCT cell disarray and characterized by irreversible nuclear damage coincident with the intranuclear accumulation of Cu, S, P, and Ca. Copper was also identified within structurally intact lysosomes associated with Zn and Fe (Type I lysosomes) or P and S (Type II lysosomes, putative Cu-MT). Subsequent copper decline and tubular recovery was associated with the facilitated lysosomal sequestration of copper and excretion of copper-containing cell products into the tubule lumina, Cu-MT and alpha-2 urinary protein-copper. The cytotoxicity of copper in the kidney, as well as the liver, is associated primarily with irreversible nuclear damage, whereas lysosomal copper sequestration protects the cell from injury.

Animals↗
PubMed1988

Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver. A mechanistic inter-relationship.

Eight structurally diverse hypolipidaemic agents have been examined for their ability to induce the microsomal cytochrome P-452-dependent fatty acid hydroxylase system and the enzymes of peroxisomal beta-oxidation in rat liver. Using a specific ELISA method, we have shown that the cytochrome P-452 isoenzyme is induced up to ten fold by hypolipidaemic challenge, concomitant with a pronounced elevation of the peroxisomal beta-oxidation enzymes, mirrored by an increase in peroxisomal volume as determined morphometrically. In addition, the induction of cytochrome P-452 is accompanied by a decrease in the activities of cytochromes P-450b and P-450c as measured by benzphetamine N-demethylase and ethoxyresorufin O-deethylase activities respectively, the latter being more extensively reduced by hypolipidaemic treatment. A hypothesis is presented whereby an early biological response is the hypolipidaemic induction of microsomal cytochrome P-452 resulting in omega-hydroxy fatty acids and their subsequent further oxidation to dicarboxylic acids, the latter providing the proximal stimulus for peroxisomal proliferation.

Animals↗
PubMed1988

Heroin users in general practice: ascertainment and features.

A case-control study of heroin users in general practice showed a prevalence of roughly two per 1000 of the urban population or four per "average" general practice list of patients. A method of studying heroin users who attend general practice was used that has advantages over existing techniques. Thirty six heroin users had a statistically significantly higher yearly doctor-patient consultation rate than a group of matched controls. More heroin users also failed to attend appointments than controls. When consultations directly related to heroin and its effects were excluded, however, the consultation rates in the two groups were similar. The heroin users did not have an excess of psychiatric disorder or disturbed family background compared with controls but had a noticeable history of dishonest and violent behaviour towards medical staff. A high proportion of heroin users in the study were antibody positive for the human immunodeficiency virus. General practitioners should take advantage of their frequent contacts with heroin users and their families to give them support and counselling about the acquired immune deficiency syndrome.

Family Practice↗
PubMed1988

Splenic resection with the Contact Nd:YAG laser system.

Splenic resection in the dog was proven to have decreased blood loss (52%), decreased operating time (44%), and decreased surgical manipulation using the SLT Contact Nd:YAG Laser System with the synthetic sapphire probe, as compared with the noncontact CO2 laser. Tissue damage and hematologic changes were minimal and equivalent in both laser systems. The overall ease of use and operating technique was subjectively better with the contact Nd:YAG laser, and the danger of scattered and reflective beam damage was eliminated. The contact Nd:YAG laser with the synthetic sapphire probes offers a significant advantage over the noncontact CO2 laser in the resection of splenic tissue. Future applications in pediatric surgery now need to be evaluated.

Animals↗
PubMed1988

Recent clinical and epidemiological trends in parasuicide in Edinburgh and Oxford: a tale of two cities.

This is a report of clinical and epidemiological trends in parasuicide in Edinburgh and Oxford over the period of 1976 to 1984. Rates of parasuicide declined in both cities, but more markedly among women than men. Male rates tended to be higher in Edinburgh and female rates higher in Oxford. Age-specific rates were similar for the two cities in 1983-84, with peak rates for females among 15-19 year olds and those for males among 20-24 year olds in Edinburgh and 25-34 year olds in Oxford. Parasuicide incidence was higher in lower social class groups and among the unemployed in both cities. During the study period there was a massive decline in barbiturate overdoses, a more modest decline in minor tranquillizer overdoses but, in Oxford, a marked increase in self-poisoning with paracetamol. By the end of the study period the proportion of patients receiving a diagnosis of drug addiction had doubled in Edinburgh, although it had remained fairly constant in Oxford. There were differences in patterns of aftercare offered to patients in the two cities; these almost certainly reflect differing clinical policies.

Adolescent↗