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Biomedical subjects

J Frederic

Publications and source records attributed to J Frederic.

At least 19 recordsLinked to original sources
PubMed1989

Mosaicism of 46,XX/47,XX,+9/47,XX,+?mar in the same amniotic fluid with apparent loss of one cell line after delivery.

A 46,XX;47,XX,+9;47,XX,+?mar karyotype was detected in an amniotic fluid cell culture and confirmed in a subsequent fetal blood sample from a 40-year-old woman. After termination of the pregnancy, none of the 186 mitoses obtained from a second blood sample was trisomic for chromosome 9 (p less than 0.001). Selection against cells containing trisomy 9 is postulated to explain the disappearance of the lymphocyte clone.

Adult↗
PubMed1987

Chromosome 22 mosaic monosomy (46,XY/45,XY,-22).

A slightly dysmorphic and mentally defective child with mosaic monosomy 22 is reported. Chromosome 22 is absent in 10.5% of lymphocytes and 8.3% of fibroblasts. This is the second case report of that kind.

Child, Preschool↗
PubMed1984

Sister chromatid exchange frequency in workers exposed to high levels of ethylene oxide, in a hospital sterilization service.

Blood samples were taken from a group of 25 subjects professionally exposed to high levels of ethylene oxide (EO) during the past two years; the samples were compared to those from 22 control subjects, using sister chromatid exchange (SCE) methodology. The quantity of ethylene oxide inhaled during the two previous years was subsequently evaluated to fall between 500 and 5800 mg. When compared with the control group, the exposed group demonstrated a significant increase in the SCE rate. For certain individuals, the rate of increase rose 100% beyond the control mean. Smoking habits significantly influenced the data observed for the control group, but no significant differences in the SCE rate were found for the exposed group, regardless of smoking habits. Senior workers had the highest SCE mean levels. This observation indicated that the effect of exposure to EO was sufficient to produce a genetic reaction, was cumulative and in some cases persistent.

Air Pollutants, Occupational↗
PubMed1983

[Increased frequency of sister chromatid exchange in persons occupationally exposed to ethylene oxide].

Mutagenic effects of ethylene oxide have been demonstrated by short-term testing in vitro and in vivo in several organisms. Its oncogenic activity for man has been suspected and recently supported by experiments in mice. Exposure can occur during ethylene oxide gas sterilization of medical materials. We have tested effects on chromosomes by estimating sister chromatids exchange (SCE) frequency. Our results, reported here, show that exposure to this substance during work is followed by a very highly significant increase of SCE frequency as compared with controls. Thus, the SCE test may, under particular conditions, represent a reliable test for exposure to certain toxic agents.

Adult↗
PubMed1982

[Cytogenetic effects of ethylene oxide poisoning].

Mutagenic effects of ethylene oxide have been demonstrated by short-term testing in vitro and in vivo in several organisms. Oncogenic activity in human has been suspected and recently supported by experiments in mice. Exposure can occur during ethylene oxide gas sterilization of medical materials. We have tested effects on chromosomes by evaluative sister chromatids exchange frequency. A statistically significant increase in the rate of SCE has been observed in workers exposed occupationally to ethylene oxide, compared with controls.

Adult↗