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J Frei

Publications and source records attributed to J Frei.

81 records · Page 5Linked to original sources
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Acute and long-term effects of prostaglandin E1 assessed by clinical and microcirculatory parameters in critical limb ischemia: a pilot study.

We treated 14 patients suffering from critical limb ischemia (CLI) as defined by the Consensus Document, and in whom possibilities of surgical or percutaneous arterial reconstruction were excluded, by PGE1 60 micrograms i.v. daily during 3 weeks. Effects were evaluated by clinical, macrocirculatory and microcirculatory parameters during a follow-up of 1 year. After treatment with PGE1, we noted a significant reduction in analgesic use and in pain score. The average tcpO2 values on the forefoot in the supine and sitting positions, with or without inhalation of O2 through a face mask, showed a significant improvement after 3 weeks, as well as capillary stage. Laser Doppler flux did not change, but was significantly higher in diabetic patients than in nondiabetics with CLI. In 4 patients (28%) no improvement could be found after 3 weeks' treatment. Although in 6 patients the improvement lasted for up to 4 months, the legs eventually deteriorated. In 4 patients (28%) the legs were preserved after 1 year without further active therapy. No patient with initial tcpO2 values above 40 mm Hg in the supine and 100 mm Hg in the sitting positions during O2 inhalation lost a leg. Although other effects like local care could have influenced the outcome favorably, we noticed a beneficial albeit transient effect of PGE1 for the majority of our patients with CLI. TcpO2 measurements with O2 inhalation might be a valuable predictor of a positive long-term result.

Adult↗
PubMedDate not supplied

Amiodarone. Therapeutics and guidelines.

Amiodarone, a newly marketed Type III antiarrhythmic, is indicated in the treatment of life-threatening ventricular dysrhythmias, including sustained ventricular tachycardia and ventricular fibrillation. Nurses who specialize in the treatment of cardiac patients should familiarize themselves with the general pharmacology of amiodarone. Specifically, nurses should be knowledgable of the considerable side effects of amiodarone and be able to translate to their patients pertinent information about prevention, detection, and management of potential side effects.

Amiodarone↗