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Biomedical subjects

J Freyschmidt

Publications and source records attributed to J Freyschmidt.

At least 73 records · Page 4Linked to original sources
PubMed1982

HLA-B27 in possible ankylosing spondylitis with peripheral arthritis.

Among 86 patients selected as possibly having ankylosing spondylitis because of clinical symptoms and radiologically normal sacroiliac joints. HLA-B27 was positive in 41%. Four years later a representative sample of 38 individuals were re-examined and radiographed. HLA-B27 positive patients developed sacroiliitis as defined by radiological criteria twice as often (P less than 0.05). They also showed increased uptake of technetium 99 m upon quantitative scintigraphy with a region of interest method and more often probable or definite ankylosing spondylitis as defined by the New York criteria. Further differences between the HLA-B27 positive and negative follow-up groups concerned the frequency of clinical symptoms and peripheral arthritis. It is suggested that HLA-B27 typing may be helpful both in diagnosis and in judging the prognosis of possible or abortive ankylosing spondylitis.

Adult↗
PubMed1982

[Computer-tomographic evaluation of tumors of the pelvis (author's transl)].

Some cases selected from a group of 35 patients with bone tumors of the pelvis (16 primary, 15 secondary malignant neoplasia, 3 semimalignant tumors, and 1 benign tumor) serve to demonstrate the significant information gained by computed tomography. In bone tumors of the pelvis neither conventional radiography nor angiography render reliable information about the extent of the tumor. Computed tomography is helpful in showing the intra- and extraosseous extent of the lesion, in demonstrating the relationship of the tumor to the organs in the neighbourhood, in measuring of volume and density and discovering the recurrence of tumor.

Adolescent↗
PubMed1982

[Possibilities of errors in radiological diagnostics of the skeleton (author's transl)].

Errors in the radiological diagnosis of the skeleton can be based on physicotechnical factors, on the use of a wrong technique of examination, or on erroneous evaluation of x-ray films. The individual factors contributing to possible errors are sub-classified and discussed as examples. An attempt is made to set up quality criteria for skeletal radiology.

Bone Diseases↗
PubMed1981

[Pachydermoperiostosis (Touraine-Solente-Golé syndrome). Clinical and radiological differential diagnosis (author's transl)].

This report describes a patient with pachydermoperiostosis (Touraine-Solente-Golé-syndrome). This disorder is characterized by clubbing of the terminal phalanges with watchglass-like nails, enlargement of hands and feet, pachydermia and periostotic skeletal changes. The signs of pachydermia are cutis verticis et frontis gyrata, ptosis and increased skin-thickness of the palms of the hand and soles of the feet. Frequently, a hyperhidrosis of the hands and feet can be found. The differential diagnosis of clinical symptoms and changes in the bones is discussed in detail.

Adult↗
PubMed1981

[Radiological changes in the skeleton due to anticonvulsant therapy in childhood (author's transl)].

Anticonvulsant therapy can lead to severe rachitic changes in the skeleton which closely resemble renal osteopathy. In addition to apparent widening of the epiphyseal plate, there are changes in the cortex of the long bones. Within four to six weeks of the commencement of vitamin D therapy, recalcification of the poorly recognised. Since the changes are best seen in the hand, further examinations of the skeleton are only indicated if there are positive findings in the hand.

Adolescent↗
PubMed1981

[Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma) (author's transl)].

Fibrous cortical defect and non-ossifying fibromas can be classified together as fibrous metaphyseal defects (FMD) since they have the same pathological substrate, with a tendency to the same localisation around the knee, and occurring at the same age. They have a tendency to spontaneous healing, are clinically silent and are usually discovered accidentally during radiological examination. A radiological survey of 5.674 metaphyseal regions in the upper and lower extremities of 2.065 unselected patients aged one to 20 years revealed an incidence of 1.8%; exclusive examination of the distal femur showed an incidence of 2.7%. 96% of all lesions were in the lower extremities and only 4% in the upper. The marked discrepancy in the incidence rate between American and German publications is discussed.

Adolescent↗
PubMed1981

[Fibrous metaphyseal defect (fibrous cortical defect, non-ossifying fibroma). Paper II: differential diagnosis (author's transl)].

FMD, whether in the stage of a fibrous cortical defect or a non-ossifying fibroma, possesses very characteristic radiological appearances which rarely make it necessary to resort to biopsy. In order to avoid mistakes, it is necessary to observe strictly the known radiological features: metaphyseal position, clearcut relationships to the cortex, well defined margins, maximal size 6 to 7 cm., presence during growth, rarely observed in the upper extremity. The differential diagnosis, which needs to be considered only rarely, is discussed.

Adolescent↗
PubMed1981

[Radiological changes in systemic lupus erythematosis (author's transl)].

In a study of 50 patients with systemic lupus erythematosis, radiologically demonstrable lung changes and pleural effusions were found in 50%. Changes in the peripheral skeleton, such as osteoporosis, erosions or mutilations, were seen in only two patients. Our radiological analysis has shown that systemic lupus erythematosis does not produce changes in the joints, but is responsible for abnormalities in the lungs, as well as for pericardial and pleural effusions.

Adult↗
PubMed1981

[Malignant fibrous histiocytoma of bone (MFH)--an new tumour? ].

Malignant fibrous histiocytoma of bone (MFH) is a histologically defined bone tumour, which can be distinguished from osteo- and fibrosarcomas. The present paper deals with the question whether MFH can be distinguished from these tumours on clinical grounds. One hundred and fifty-seven previously published, and four additional cases have been analysed with respect to their localisation and their biological, clinical and radiological behaviour and their prognosis. It was found that MFH can be distinguished from osteosarcomas on clinical grounds and that this is significant in relation to treatment; its distinction from fibro-sarcomas is clinically not justified.

Adolescent↗
PubMed1981

[EMO-syndrome. Clinical and roentgenologic signs].

The EMO-syndrome (thyroid acropachy) consists of the triad of exophthalmos, circumscribed pretibial myxedema and clubbing of fingers and toes. This report describes a patients with EMO-syndrome. The skeletal changes are discussed.

Adult↗
PubMed1980

[On the problem of knee joint articular space in the x-ray film (author's transl)].

Measurements of the width of the intraarticular space were performed in x-ray films of 64 human knee joints (32 patients), taken laterally, and in standing position after 24 hours of rest in bed or after exposure to load for one hour. In more than half of the knee joints, the width of the intraarticular space increased after load. However, the distance between the articular surfaces rarely changed in the same patient in the same sense in the right and left knee joint, respectively medially and laterally. Hence, this method of indirect measurement of the cartilaginous layer is unsuitable, and the question raised in literature regarding the cartilaginous changes under load can be explained as being due to influx of fluid or as an expression of the viso-elastic properties of the articular cartilage.

Adolescent↗
PubMed1980

[X-ray of osteopathies (author's transl)].

Osteoporosis, osteomalacia, fibro-osteoclasia and osteosclerosis are essential reactions to pathologico-metabolic processes of the bone. The x-ray film shows precisely which changes have taken place in the bone structure, thus supplying the means for an analysis based on anatomic pathology. These phenomena are discussed in detail, special attention being paid to structural modifications. Attention is also focused on the problems connected with x-ray technology. The value of direct and indirect magnification of the skeleton of the hand for the identification and classification of osteopathies is explained. Phenomena observed in x-ray films, such as enosteal erosion, intracortical longitudinal stripes or tunnelisation, as well as subperiostal absorption, can be of pathognomonic importance for certain osteopathies.

Bone Diseases↗
PubMed1980

[On the clinical value of roentgenological observation of the clinical course of renal osteopathy (author's transl)].

Basing on radiological observation of the course of renal osteopathy confirmed both clinically and by bone biopsy in 96 patients -- the x-ray examination comprising primarily the entire axial skeleton including the proximal extremities and hands -- 60% of the patients showed mineralisation in their hands. The rest of the skeleton was affected only if there were identifiable alterations at the hands, although the affection of the axial skeleton was definitely lower in terms of percentage. Hence, radiological observation of renal osteopathy based on x-ray films of both hands with additional magnification technique appears both possible and meaningful.

Adolescent↗