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Biomedical subjects

J Freyschmidt

Publications and source records attributed to J Freyschmidt.

At least 109 records · Page 6Linked to original sources

[Radiculo-tomography for lumbosacral myelography (author's transl)].

The use of tomography can increase the value of lumbosacral myelography in certain circumstances. Post mortem studies have resulted in standardisation of the examination, which will combine optimal diagnostic information with the least amount of effort and with an acceptable amount of stress on the patient. 110 tomographic examinations were performed amongst 680 lumbosacral myelograms (Dimer X). On the basis of this experience, the value of this procedure is illustrated from various points of view and its indications are discussed.

Humans↗

[The effect of haemodynamic factors on tomograms during angio-tomography (author's transl)].

Haemodynamic factors may influence the appearance of the tomograms during the performance of angio-tomography. Model experiments have shown that the thickness of section able to demonstrate vessels may depend on the relationship between vessel opacification and the timing of the cut. The clinical relevance of this is illustrated by tomographic studies of the renal and cerebral circulations.

Angiography↗

X-ray enlargement modified for use in experimental animal science.

The primary enlarged x-ray image is produced by a reduction of the focal-film-distance to 80 cm at a given focal size of 0-15 mm. The advantages of this technique as compared to conventional x-ray methods are exemplified with x-ray images from the shoulder joint of a European hamster, a pseudoarthrosis in the foreleg of a beagle, and a renovasography of a rat. The principles of the technique and its significance for investigations using small laboratory animals are discussed.

Animals↗

[A new model for reflux prevention following distal and total stomach resection].

By means of a short isoperistaltic invagination of a small bowel segment a valve mechanism has been developed experimentally. After complete or partial gastric resection (B II) reflux of alkaline intestinal secretion could be prevented. Even under extreme pathological conditions like head down position and external compression normal valve function has been achieved.

Animals↗

[The "bull horn sign"--scintigraphic pattern in sternocostoclavicular hyperostosis and pustular arthro-osteitis].

27 patients with sternocostoclavicular hyperostosis (SCC) and/or pustulotic arthroosteitis (PAO) were examined with whole body scintigraphy, conventional radiography, and other imaging modalities, such as CT, MRI. 25 of 27 patients with SCCH showed a characteristic high bullhorn-like uptake of the sternocostoclavicular region with the manubrium sterni representing the skull and the inflamed sternocostoclavicular joints corresponding to the horns (= bullhorn-sign). Scintigraphy revealed additional skeletal manifestations (spondylitis, sacroilitis, osteitis, periostitis) in 19 of the 27 patients with SCCH and/ or PAO. In combination with PPP or psoriasis pustulosa, the typical scintigraphic bullhorn pattern enables the diagnosis of PAO (19 patients) with high confidence. Patients with SCCH but without skin disease at the time of presentation (8 of 27 patients) may develop PPP later and, therefore, it is justified to classify them as incomplete PAO with high risk to develop other skeletal manifestations later in the course of the disease.

Adult↗

Evaluation of early diagnostic criteria for ankylosing spondylitis in a 10 year follow-up.

A set of early diagnostic (ED) criteria comprising clinical data, ESR, radiological spinal signs, and the risk factor HLA B27 was evaluated after 5 and 10 years in a follow-up of 54 patients with an initial diagnosis of possible ankylosing spondylitis (AS). After 10 years 32 patients (59%) had developed definite AS according to the New York criteria, 10 individuals (19%) had possible or undifferentiated spondylarthropathy (SA), whereas in 12 patients (22%) other diagnoses were stated. ED criteria had a high discriminatory significance for the development of AS after 5 and 10 years (P less than 0.005, P less than 0.001 respectively). In this respect they were more valuable than B27 determination alone (P less than 0.01) or the ED criteria without HLA B27 (P less than 0.05). Furthermore, patients with still possible or undifferentiated SA had a higher mean score at the first examination than individuals with other final diagnosis (P less than 0.05). Thus, the ED criteria were useful for the identification of patients developing definite AS and of individuals in the AS related group of possible or undifferentiated SA.

Back Pain↗

Evaluation of early diagnostic criteria including HLA-B27 for ankylosing spondylitis in a follow-up study.

Early diagnostic criteria, a combination of the HLA-B27 test with clinical data, ESR and radiological signs, were evaluated in a 5-6 year follow-up study of 77 patients with possible ankylosing spondylitis (AS) and 45 with other rheumatic diseases. 34 (44%) with possible AS at first examination developed definite AS according to the New York criteria and 29 (38%) were classified as still possible AS. From these data a sensitivity of 82%, a specificity of 68%, a positive predictive value of 50% and a negative predictive value of 91% were calculated. Therefore the early diagnostic criteria, although of limited value for the diagnosis of definite AS, may clearly define patients at risk of AS or unclassified seronegative spondylarthropathies.

Adult↗