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Biomedical subjects

J Friemann

Publications and source records attributed to J Friemann.

At least 19 recordsLinked to original sources
PubMed1995

Muscarinic receptors in gastric mucosa are increased in peptic ulcer disease.

Muscarinic receptors stimulate the secretion of acid pepsinogen and mucous in gastric mucosa. Whether muscarinic receptors are involved in the pathogenesis of benign gastric disease is unknown. Receptor changes in these conditions were therefore sought. An autoradiographic technique was developed to determine quantitatively muscarinic receptors in microtome sections of biopsy specimens obtained during gastroscopy. Muscarinic receptor density was mean (SEM) 18.4 (1.2) fmol/mg protein in the corpus and 8.9 (0.7) fmol/mg protein in the antrum (n = 53). Neither chronic nor active gastritis was associated with receptor changes in the antrum but chronic gastritis was associated with a receptor loss in the corpus. Patients with acute or recent duodenal or antral ulcers (n = 23) had significantly higher levels of muscarinic receptors in the corpus than controls (n = 25) (22.2 (1.5) v 16.9 (1.7) fmol/mg protein respectively (p < 0.025). These results suggest that muscarinic M3 receptor is overexpressed in duodenal ulcer disease and may play a part in its pathogenesis.

Acute Disease↗
PubMed1994

[Elevated p53 protein expression in normal and neoplastic light-exposed epidermis].

p53 protein levels are frequently elevated in basal (BCC) and squamous (SCC) cell carcinomas of UV-exposed sites. As recent findings in benign epidermal neoplasia (BEN) and normal epidermis (NE) are controversial, our aim was to look by immunohistochemistry for elevated p53 levels in NE (n = 52), reactive hyperplastic epidermis (REH, n = 8), BEN (n = 48), actinic keratosis (AK, n = 60), SCC (n = 13), and BCC (n = 42) of sun-exposed sites. 81.7% of AK, 100% of SCC, 73.8% of BCC as well as 29.2% of BEN, 37.5% of REH, and 26.9% of NE showed p53 positivity. The results further support that p53 elevated levels are an early marker of UV-mediated epidermal DNA damage.

Basal Cell Carcinoma↗
PubMed1991

Ultrastructure of mesothelial regeneration after intraperitoneal injection of asbestos fibres on rat omentum.

In order to describe the ultrastructural features of the early phases of regenerating mesothelium in rat peritoneum, 69 cases were examined after intraperitoneal injection of 0.05-15 mg crocidolite, chrysotile B and other mineral and synthetic fibers. The findings show the presence of intermediate or transition cells between proliferating submesothelial connective tissue cells bearing the ultrastructural phenotype of myofibroblasts and mature fully regenerated mesothelium. Our results and data accumulated in the literature provide strong support for the hypothesis of submesothelial cells origin for regenerating mesothelium.

Animals↗
PubMed1990

Mesothelial proliferation due to asbestos and man-made fibres. Experimental studies on rat omentum.

The intraperitoneal test in rats has proven to be an appropriate method controlling fibrogenicity and carcinogenicity of asbestos fibres and other fibrous dusts. We analyzed the reaction patterns of mesothelial cover layer to different natural mineral fibres (crocidolite, chrysotile, actinolite, erionite, wollastonite) and man-made mineral and synthetic fibres (glass fibres 104/475, polypropylene, aramide fibres). The injection of doses between 0.01 and 100 mg dust suspended in saline solution led to a continued repairing proliferation of submesothelial connective tissue cells and focal submesothelial fibrosis. These changes were never observed after application of granular dusts as mine dust and quartz. After 15 to 28 months we often found an association of fibrosis and local reactive hyperplasia of partly atypical proliferation of rat omentum mesothelium. These changes were also demonstrated in cases without macroscopically visible tumors. In later stages the underlying fibrosis was often infiltrated and dissolved by mesotheliomas.

Animals↗
PubMed1990

[Significance of sonography of the breast for surgical treatment of breast cancer].

In a prospective study of 119 patients with breast carcinoma the value of ultrasonography for surgical therapy was compared with the value of clinical results and mammography. The tumor localization (in 96.8%) and the exact preoperative staging following the pTNM-system (tumor size in 85.8%, lymph node involvement in 77.2%) were better predicted by ultrasonography than by mammography and clinical examination. Especially the multicentric-multifocal carcinomas (20 of 29 cases) were better detected. Preoperative ultrasonography especially improves planning a conservative management of breast cancer.

Breast Neoplasms↗
PubMed1990

[Perioperative ultrasound examination of the breast in breast cancer].

127 cases of breast carcinoma were examined in a prospective study. By means of preoperative ultrasonography the staging following the pTNM-system validates the tumor size in 85.5% and the lymph node involvement in 77.2%. Multicentric-multifocal carcinomas were diagnosed by ultrasonography in 20 of 29 cases, merely 9 of 29 by mammography. Ultrasonography of specimen is recommended in cases of negative clinical findings and positive ultrasound examination to verify tumour excision. In addition to clinical exploration and mammography the ultrasonography of the breast obtains a diagnostic significance for planning a conservative management of breast cancer.

Breast Neoplasms↗
PubMed1987

Asbestos induced fibrosis in the omentum of rats. Immunofluorescence microscopical demonstration of collagens types I and III; laminin and fibronectin.

Fibrosis and neoplasia are evoked by asbestos fibres. Different experimental models have been used to elucidate the cellular mechanism of their pathogenesis but there is no report available dealing with the role of structural glycoproteins and collagens in the development of the fibrosis. The omentums of 20 female SPF-Sprague-Dawley rats were investigated 1, 2 and 6 months after intraperitoneal injection of 15 mg UICC reference samples of crocidolite, by light- and immunofluorescence microscopy. Using monospecific antibodies, laminin, collagens types I and III and fibronectin were localized. After 6 months typical asbestos bodies were detected. By indirect marking of the basal lamina with anti-laminin-antibodies the marked degree of vessel proliferation occurring during the development of granuloma became visible. The deposition of connective tissue which was already established after 4 weeks was mainly due to collagen type III. After 4 and 8 weeks an accumulation of fibronectin associated with larger asbestos fibres was observed. The results suggest that fibrogenesis is promoted by the opsonic activity of fibronectin for long asbestos fibres. The fibrosis may derive from activated resident fibroblasts.

Animals↗
PubMed1987

[Primary and secondary chest wall tumors from the pathologist's viewpoint].

Fibrous dysplasia (20%), metastases (16%) and chondrosarcoma (11%) are the most common bone tumors of the chest wall. Except lipoma, primary lesions of the soft tissue of the chest occur rarely as well. The Askin- and Abrikosoff tumor, elastofibroma dorsi and desmoid can be seen as typical exceptions. With respect to the histogenetic classification of undifferentiated sarcomas and thoracic metastases (f.e. prostatic carcinomas or mesotheliomas) an intimate cooperation of surgeons and pathologists as well as modern immunohistochemical investigations are required.

Bone Neoplasms↗
PubMed1986

[Decision aids in determining therapy of breast cancer by preoperative staging using sonography and computerized tomography].

In a prospective study the preoperative ultrasonography of 54 cases of carcinoma of the breast was able to predict the pTNM staging precisely in 83.3% for tumor size and in 72.3% for lymphnode metastases. Multicentric-multifocal carcinomas were diagnosed by ultrasonography in 10 of 13 patients, better than by mammography (6 of 13). The CAT scan is indicated only in advanced tumor stages. The preoperative staging by ultrasonography enables with more precision planning and differentiated therapy of the carcinoma of the breast, especially in view of breast-preserving therapy.

Breast↗
PubMed1985

Effects of trilostane in normotensive and hypertensive rats.

The effect of trilostane, a competitive inhibitor of 3 beta-hydroxysteroid dehydrogenase, on adrenal tissue and blood pressure was studied in normotensive and spontaneously hypertensive rats. The drug was administered orally in doses of 10, 200 and 650 mg/kg/day for 2 and 4 weeks. Trilostane induced an increase in adrenal weight by lipoid transformation of the zona fasciculata. Simultaneously a reduction of retroperitoneal fat tissue was seen in all animals. A significant increase in blood pressure was observed under a trilostane medication of 650 mg/kg/day in normotensive as well as in spontaneously hypertensive rats. Blood pressure under lower doses did not increase significantly. Both increase of blood pressure and reduction of retroperitoneal fat tissue might be caused by increased release and synthesis of catecholamines.

3-Hydroxysteroid Dehydrogenases↗
PubMed1984

Scintigraphic localization of phaeochromocytomas.

131I-meta-iodobenzylguanidine scanning was performed in 14 patients with phaeochromocytomas. In all but one patient scintigraphy successfully localized the lesion(s). The results confirm that scintigraphic imaging with 131I-meta-iodo-benzylguanidine, a noninvasive method, is a valid and reliable procedure for imaging and localization of adrenal and extra-adrenal phaeochromocytomas, both benign and malignant.

3-Iodobenzylguanidine↗
PubMed1984

Role of kidney and adrenals in the humoral pathogenesis of primary hypertension.

In 18 spontaneously hypertensive rats (SHR) of the Münster strain the circulation was connected to that of normotensive animals using the carotid arteries and external jugular veins. The circulations were mixed by a peristaltic pump. In this model the normotensive rats were made hypertensive after a 10-min cross-perfusion cross unidentified humoral factors causing vasoconstriction play an essential role for the development of hypertension in SHRs.

Adrenal Glands↗