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Biomedical subjects

J Frottier

Publications and source records attributed to J Frottier.

137 records · Page 8Linked to original sources
PubMedDate not supplied

Pulmonary cryptosporidiosis in the acquired immunodeficiency syndrome.

Since the beginning of the AIDS epidemic, Cryptosporidium has emerged as a pathogen responsible for diarrhea in humans. Cryptosporidiosis confined to the respiratory tract has been documented only rarely in humans. An HIV-infected patient is described here, who developed pulmonary and intestinal cryptosporidiosis. Lung involvement was proven by biopsy, which also revealed bronchiolitis but no other pathogens. The patient died of respiratory failure 2 months after the onset of respiratory symptoms.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

[Problems posed by therapeutic combinations of zidovudine during the treatment of opportunistic infections in AIDS].

Opportunistic infections in patients with acquired immunodeficiency syndrome (AIDS) require hematotoxic drugs. Neutropenia and anemia are the major hematologic abnormalities attributed to zidovudine (AZT). Concomitant medications associated with an increased frequency of toxicity are trimethoprim-sulfamethoxazole (cotrimoxazole), sulfadiazine, pyrimethamine, ganciclovir. AZT is stopped during initial treatment then reintroduced at full dosage with cotrimoxazole, at reduced dosage with sulfadiazine + pyrimethamine or ganciclovir.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Current importance of resistance of group A streptococci to tetracyclines].

The resistance of group A streptococci to tetracyclines is a long-standing phenomenon, observed in numerous countries. Sixty strains of group A streptococcus, isolated in 1975 and 6976 at the Claude Bernard Hospital, were tested against natural and semi-synthetic tetracyclines and penicillin G. Whilst sensitivity to the latter was constant, approximately 30% of strains were resistant to tetracyclines. Amongst them, minocycline was nevertheless a little more active than natural tetracycline and doxycycline. The mechanism of this resistance would seem to be extra-chomosomal.

Penicillin G↗