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Biomedical subjects

J Frucht

Publications and source records attributed to J Frucht.

11 recordsLinked to original sources
PubMed1996

[Effect of the contour line on cup surface using the Heidelberg Retina Tomograph].

BACKGROUND: Significance of topometric follow-up examinations of the optic nerve head in glaucomatous eyes depends on the reproducibility of the calculated parameters. Since the definition of the standard reference plane in software version 1.11 of the Heidelberg Retina Tomograph has been changed, intrapapillary parameters depend directly on the position of the contourline in the sector between -10 degrees to -4 degrees, and therefore on the observer variability to determine the disc border. We evaluated intra- and interobserver variability and present a simple approach to increase reproducibility. METHOD: The disc border of 4 glaucomatous eyes, 3 ocular hypertensive eyes and 3 eyes of healthy subjects were traced by two observers, 5 times using the free draw mode and 5 times by the addition of contourline circles. RESULTS: We found a median variability of the mean disc radius in sector -10 degrees to -4 degrees of 51 microns, which defines the position of the standard reference plane, resulting in a median variability of the position of the standard reference plane of 33 microns which caused a variability of 81 microns2 of the cup area. Addition of contourline circles smoothing the final contourline along the border of the optic disc resulted in a decrease of the coefficient of variation of the standard reference plane of 3.76% (6.76% vs. 3.0%), of the cup area of 2.34% (3.87% vs. 1.53%) and of the rim volume of 3.41% (9.75% vs. 6.34%). CONCLUSION: The calculation of the cup area using software version 1.11 of the Heidelberg Retina Tomograph depends on observer variability. The addition of contourline circles to define the final contourline along the disc border increases reproducibility. However, in follow-up of topometric examinations of the optic nerve head the software supported transfer mode should be used. Comparing topometric data of an individual optic disc in follow-up suppose the same definition of the contourline. Therefore, topometric data evaluated using software version 1.10 or earlier needs to be recalculated.

Adolescent↗
PubMed1986

Use of infant and child corneas for grafting.

Six corneal transplants, for which donor material was taken from infants or children, were grafted in adults with different types of corneal pathology. Acceptable mean keratometric readings of 45.8 diopters were obtained 6 months after surgery, very similar to those of grafted corneas taken from adults. After 3 years of follow-up, we found complications similar to those of corneas taken from adult donors. No technical problems were encountered while using infants' or children's donor material. We suggest that this type of donor be considered for corneal transplantation in countries where sufficient adult corneas are not available.

Adult↗
PubMed1985

Early intraocular pressure response following laser trabeculoplasty.

The early response in the intraocular pressure following laser trabeculoplasty was investigated in 38 patients. An increase in pressure was found in 16 patients (42%), of whom eight had a moderate (less than 9 mmHg) and eight a severe (greater than 10 mmHg) increase. The maximum increase was recorded during the first post-laser hour in 13 patients (34.2%) and at 4 h in three patients postoperatively. A routine follow-up observation at 4 h after laser treatment is recommended to prevent 'silent' hypertensive risk.

Aged↗
PubMed1984

Central retinal vein occlusions in young adults.

This study was a long term follow-up of 11 young adults aged 15-45 with central retinal vein occlusion (CRVO). Seven patients classified as the ischemic type of CRVO showed a poor visual acuity at the first examination and did not improve throughout the study. In addition, systemic diseases were found in all these patients. Four patients classified as venous stasis retinopathy type of CRVO, had, in contrast, fairly good visual acuity at the first examination and showed additional improvement during the follow-up period. No systemic diseases were detected. Physical examinations are recommended periodically for young adults with ischemic type of central retinal vein occlusion.

Adolescent↗
PubMed1984

Intraocular pressure in retinal vein occlusion.

The intraocular pressure of 59 patients with retinal vein occlusion was studied. Central retinal vein occlusion (CVO) was diagnosed in 24 patients and branch retinal vein occlusion (BVO) was diagnosed in the rest. The intraocular pressure of a sex and age matched group of controls was also studied for comparison. The intraocular pressure in the CVO group were significantly different from those of the matched controls (p less than 0.001). A statistically significant difference of a lesser degree (p less than 0.05) was also found in a comparison of the intraocular pressures of the BVO group with those of their sex and age matched group of controls. These findings may indicate the possible role of increased intraocular pressure in the pathogenesis of CVO and BVO.

Constriction, Pathologic↗
PubMed1984

Ocular side effects of disopyramide.

A patient who suffered from severe decrease of accommodation and pupillary dilatation following the systemic use of disopyramide is described. The ocular side effects when this drug is used in large doses result from its anticholinergic action.

Accommodation, Ocular↗
PubMed1984

Topical indomethacin effect on neovascularisation of the cornea and on prostaglandin E2 levels.

The effect of indomethacin 1% drops against a placebo (NaCl 0.9% solution) was tested in rabbits' corneas injured by a standardized chemical burn. The corneas treated with indomethacin 1% had less neovascularisation and a much smaller increase in the PGE2 levels as compared with the control fellow eyes treated with a placebo. It appears that indomethacin 1% drops have a clear effect on the inflammatory response of the cornea and deserve a clinical trial in selected patients suffering from corneal inflammatory changes.

Administration, Topical↗
PubMedDate not supplied

The normalised rim/disc area ratio line.

The assessment of the cup of the optic disc depends, among other criteria, on the disc area. A small cup in a small optic disc can indicate an advanced glaucomatous lesion, on the other hand a large cup in a large optic disc can be normal. Therefore, an individual normalised rim/disc area ratio line together with the curves of 50th percentile and the 95th percentile of normal could help to better distinguish between glaucomatous and normal optic cups. The aim of our study was to calculate and to evaluate such a normalised rim/disc area ratio line. Heidelberg Retina Tomograph examinations of the optic nerve head of 100 randomly selected eyes of 100 normal subjects were evaluated. We calculated the disc area adjusted rim/disc area ratio in sectors of 10 degrees. The 95th percentile and the 50th percentile of each of the 36 sectors were calculated. Based on these normal percentile lines it was possible to display an individual normalised rim/disc area ratio line in the topographic images of an individual optic disc examination. Here we demonstrated examples of a normal optic disc, optic nerve heads with moderate and advanced lesions and a small optic disc with glaucomatous damage. We present a new display mode of the results of Heidelberg Retina Tomograph optic nerve head examination, which may be helpful for an easy and reliable assessment of glaucomatous optic nerve head damage only looking at topographic images.

Adolescent↗