Biomedical subjects
J G Blaivas
Publications and source records attributed to J G Blaivas.
Defining words: overactive bladder.
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Tissue strength analysis of autologous and cadaveric allografts for the pubovaginal sling.
The aim of this study was to compare the mechanical properties of autologous rectus fascia (ARF), two groups of commercially available cadaveric fascia lata commonly used in pubovaginal sling surgery [freeze-dried (FD) and solvent-dehydrated (SD)], and commercially available cadaveric dermal grafts (DG) evaluate differences in tissue strength and stiffness. We prospectively studied the maximum load to failure (MLF) and stiffness in 20 specimens of ARF, 20 specimens of FD, 20 specimens of SD, and 10 specimens of DG. Autologous fascia was obtained from patients undergoing pubovaginal sling operation utilizing rectus fascia. Cadaveric fascia was re-hydrated in saline. All specimens were then tailored into 1 x 1-cm samples and mounted onto the Instron tensiometer. Samples were loaded to failure at a 100% strain rate and force-elongation curves were generated. MLF was defined as the minimum force needed to tear the tissue. Stiffness was determined by the slope of the linear portion of the force/elongation curve between 5 and 15% strain. Statistical analysis was performed using Student's t-test. There is no statistical difference in both MLF and stiffness among ARF, SD, and DG. These data show that MLF and tissue stiffness of SD and DG are comparable to that of ARF. FD has a significantly lower MLF and is significantly less stiff than ARF, SD, and DG. The SD cadaveric fascia lata allograft and the cadaveric dermal allograft may be suitable alternatives to ARF for pubovaginal sling surgery. Neurourol. Urodynam. 18:497-503, 1999.
Conflict of interest.com.
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Evaluation of the etiology of nocturia in men: the nocturia and nocturnal bladder capacity indices.
To determine and quantify the cause of nocturia in men, we describe and evaluate the relative contribution of two complementary indices of nocturia: the nocturia index (Ni), a measure of nocturnal urine overproduction, and the nocturnal bladder capacity index (NBCi), reflective of nocturnal bladder capacity. The records of 100 consecutive men with lower urinary tract symptoms (LUTS), having undergone video-urodynamic studies (VUDS), were prospectively studied. Evaluation included American Urological Association symptom score (AUASS), micturition diary (day, night, and 24-hr voided volume), and VUDS. Voiding diary analysis was carried out as previously described by us, determining the Ni, NBCi, and nocturnal polyuria index (NPi) (nocturnal urine volume/24-hr urine volume). In the case of AUASS question #7 (degree of nocturia), the odds of having a severe AUA question #7 response was found to be 4.09 times higher for patients with NBCi > 2.0 compared with patients whose NBCi was </= 2.0 using logistic regression analysis. In comparing patients with severe nocturia and low NBCi with those having mild nocturia and low NBCi, Ni performed in a fashion superior to NPi in identifying relative nocturnal urine overproduction as the suspected explanation for their nocturia (Ni = 3.42 vs. 1.42, P = 0.0002 cf. Npi = 0.44 vs. 0.27, P = 0.018, Mann-Whitney test, respectively). We suggest a discriminating threshold of NBCi > 2 as highly significant in defining diminished NBC as a factor in the etiology of nocturia. In addition, we propose Ni of 1.5 as a threshold greater than which nocturia may be attributed to nocturnal urine overproduction in excess of maximum bladder capacity. Together, these indices describe in quantitative fashion the relative contributions of nocturnal urine overproduction and diminished NBC in identifying the etiology of nocturia in male patients. Neurourol. Urodynam. 18:559-565, 1999.
Suprameatal transvaginal urethrolysis.
PURPOSE: We describe and assess a method of urethrolysis using a transvaginal suprameatal approach without lateral perforation of the urethropelvic ligament. MATERIALS AND METHODS: Between March 1993 and December 1997, 32 consecutive women 32 to 79 years old underwent suprameatal transvaginal urethrolysis at 2 institutions. In all cases anti-incontinence surgery was done previously, including a pubovaginal sling procedure in 12, Marshall-Marchetti-Krantz procedure in 8, Burch colposuspension in 6, modified Pereyra transvaginal urethropexy in 4, and Gittes suspension and anterior repair in 1 each. Of the 32 patients 20 were in urinary retention and 12 had primarily urge and/or irritative voiding symptoms, or urge incontinence. In the patients in urinary retention average maximal detrusor pressure was 41.4 cm. water. In all cases physical examination, cystourethroscopy and video urodynamics were done before suprameatal transvaginal urethrolysis. Obstruction was defined as detrusor pressure greater than 20 cm. water at maximum urinary flow of less than 12 ml. per second. Urethral obstruction was presumed when examination revealed urethral angulation, tethering, narrowing or scarification. Impaired detrusor contractility was diagnosed when detrusor pressure at maximum urinary flow was less than 20 cm. water at maximum urinary flow of less than 12 ml. per second. RESULTS: After suprameatal transvaginal urethrolysis 13 of the 20 women (65%) in urinary retention voided well and in 8 of the 12 (67%) with urgency symptoms resolved. Postoperative stress urinary incontinence developed in only 1 case. CONCLUSIONS: The success rate of suprameatal transvaginal urethrolysis to treat urinary obstruction associated with anti-incontinence procedures compares favorably to that of other described alternative approaches. The success rate in patients with definite urodynamic criteria for obstruction was not significantly better than in those who underwent suprameatal transvaginal urethrolysis based on physical examination and clinical judgment. Preoperative maximal urinary flow rate was associated with operative success (p = 0.018), while preoperative post-void residual urine and maximum detrusor pressure failed to reveal a difference between operative success and failure.
Results of pubovaginal sling for stress incontinence: a prospective comparison of 4 instruments for outcome analysis.
PURPOSE: Presently to our knowledge there are no standardized techniques to assess outcomes after surgery for stress incontinence. We performed a prospective blinded study to assess the correlation among physician and patient assessments, and a validated 24-hour pad test and voiding diary. MATERIALS AND METHODS: A total of 84 women were evaluated before and after pubovaginal sling for stress incontinence with a voiding diary, pad test and symptom questionnaire (patient assessment) administered by a blinded third party. The operating surgeon evaluated the patient using history, physical examination, pad test and voiding diary but was blinded to results of the outcome questionnaire. Preoperative focused neurourological examination and video urodynamics confirmed stress incontinence. Patients were assessed at least 1 year postoperatively. We compared patient assessment (cured, improved, failure) to the outcome of the pad test, voiding diary and physician assessment. The physician and questioner were blinded to each other. We considered patients with a pad test of 0 to 2 ml. as cured, 50% or more volume reduction as improved and less than 50% volume reduction as failure. Postoperative assessment did not differentiate between stress and urge incontinence. The kappa coefficient was used for statistical comparison. RESULTS: Average patient age was 58 years and average followup for the entire group was 4 years. Agreement among the 4 instruments to assess outcome was excellent (k >0.9) with respect to cured/improved versus failure but only good for cured versus improved versus failure (k >0.5). CONCLUSIONS: Outcomes following incontinence surgery may vary depending on how the analysis was performed, patient selection, definition of success and so forth. Our results indicate that a pad test and voiding diary are reliable and should be part of the normal followup after pubovaginal sling for sphincteric incontinence. When these tests are used in conjunction with defined parameters of success, there is excellent agreement with patient feelings in regard to success or failure of surgery. Nevertheless, these instruments and methods are imperfect at best.
The effect of genital prolapse on voiding.
PURPOSE: We determined whether genital prolapse causes obstruction that may be relieved by a vaginal pessary as well as the degree to which voiding difficulty, urethral hypermobility, bladder outlet obstruction, occult stress incontinence, detrusor instability and impaired detrusor contractility are associated with prolapse. MATERIALS AND METHODS: We prospectively evaluated 60 women with a mean age of 52 years who had genital prolapse, including 35 (58%) with grade 1 or 2 and 25 (42%) with grade 3 or 4 cystocele, using pressure-flow video urodynamics and cotton swab testing. Leak point pressure and uroflowmetry were repeated in patients with severe prolapse after insertion of a ring pessary. RESULTS: Urethral hypermobility (p<0.05) and symptoms of voiding difficulty (p<0.01) were more common in women with grade 3 or 4 cystocele. Urodynamics revealed bladder outlet obstruction in 2 patients (4%) with grade 1 or 2 cystocele and 18 (58%) with grade 3 or 4 cystocele (p<0.001). After vaginal pessary placement bladder outlet obstruction reverted to normal free flow in 17 women (94%) with grade 3 or 4 cystocele. Seven women (20%) with grade 1 or 2 cystocele versus 13 (52%) with grade 3 or 4 cystocele had detrusor instability (p<0.05). Impaired detrusor contractility was noted in each group (p>0.05). In patients with stress incontinence intrinsic sphincter deficiency did not correlate with the degree of prolapse and urethral hypermobility did not correlate with leak point pressure. CONCLUSIONS: Lower urinary tract symptoms are common in women with genital prolapse. Voiding difficulty, bladder outlet obstruction and occult stress incontinence may coexist and they are associated with prolapse. Detrusor instability and urethral hypermobility also correlate with the degree of prolapse but impaired detrusor contractility and intrinsic sphincter deficiency do not. In women with severe prolapse ring pessary reduction of prolapse during urodynamics is useful to determine symptomatic and occult conditions.
"If you build it, they will come".
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Medical identification numbers: a good idea that won't work...yet.
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Nocturia in adults: etiology and classification.
Nocturia is one of the most bothersome of all urologic symptoms, yet even a rudimentary classification does not exist. We herein propose a classification system of nocturia based on a retrospective study. The records of 200 consecutive patients with nocturia were reviewed. Evaluation included history, micturition diary (including day, night, and 24-hr voided volume), postvoid residual urine (PVR), and videourodynamic study (VUDS). Functional bladder capacity (FBC) was determined to be the largest voided volume in a 24-hr period. The etiology of nocturia was thus classified into one of three groups: nocturnal polyuria ([NP] in which voided urine volume during the hours of sleep exceeds 35% of the 24-hr output), nocturnal detrusor overactivity ([NDO] defined as nocturia attributable to diminished bladder capacity during the hours of sleep), and mixed (NP+NDO); polyuria (24-hr urine output >2,500 cc) was classified separately. There were 129 women and 65 men ranging in age from 17 to 94 years (x=59). Overall 13 (7%) had NP, 111 (57%) NDO, and 70 (36%) had a mixed etiology of their nocturia (both NP and NDO). Forty-five (23%) also had polyuria. These data confirm that the etiology of nocturia is multifactorial and in many instances unrelated to the underlying urologic condition. Nocturnal overproduction of urine is a significant component of nocturia in 43% of patients, most of whom will also have NDO. We believe that treatment should be directed at both conditions.
Health care for all.
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Outcome measures for urinary incontinence.
UNLABELLED: OBJECTIVES; To discuss the rudiments of data that need to be collected in order to develop validated, reproducible, well-accepted efficacy instruments for assessing treatment outcomes in urinary incontinence (UI). METHODS: Information is presented from two reports issued by the Urodynamics Society: "Definition and Classification of Urinary Incontinence" and "Standards of Efficacy for Evaluation of Treatment Outcomes in Urinary Incontinence." RESULTS: Instruments to assess the efficacy of treatment should be reliable and valid. Such instruments include structured histories, questionnaires, structured physical examinations, urodynamics, voiding diaries, and pad tests. Recommended primary outcome variables include the number of incontinent episodes, volume of urinary loss, and type of incontinence. Secondary measures include patient satisfaction, quality of life, bladder symptoms, uroflow, postvoid residual urine, and other urodynamic variables. General considerations for the development of clinical trials include 1) using a standard lexicon, 2) consistent timing of follow-up, 3) proper outcome assessment at each follow-up, 4) proper data collection, 5) proper data analysis, and 6) formulating conclusions that are supported by the data. CONCLUSIONS: At the present time, there are no validated, reproducible, well-accepted efficacy instruments for assessing treatment outcomes in UI. Further work directed toward the development of such instruments is warranted.
Pubovaginal fascial sling for all types of stress urinary incontinence: long-term analysis.
PURPOSE: There is a lack of consensus regarding indications and long-term efficacy of the many surgical techniques for treating stress incontinence. Historically pubovaginal sling has been reserved for cases of intrinsic sphincter deficiency or prior surgical failure. Transvaginal needle and retropubic suspensions have been used mainly for sphincteric incontinence unassociated with intrinsic sphincter deficiency. We report the long-term results of pubovaginal sling for all types of stress incontinence. MATERIALS AND METHODS: A total of 251 consecutive women with all types of stress incontinence who underwent pubovaginal fascial sling by a single surgeon were retrospectively and prospectively reviewed. Patients were evaluated preoperatively with history, physical examination, standardized symptom questionnaire, voiding diary, pad test, uroflow, post-void residual urine, video urodynamics and cystoscopy. Postoperatively women with at least 1-year followup were assessed by an independent third party (J. R.) who had no prior knowledge of them, and who recorded the parameters of the questionnaire, examination with a full bladder, voiding diary, pad test, uroflow and post-void residual urine. RESULTS: Overall stress incontinence was cured or improved in 92% of the patients with at least 1-year followup (median 3.1 years, range 1 to 15). The majority of patients with postoperative incontinence had de novo (3%) or persistent (23%) urge incontinence. Permanent urinary retention developed in 4 patients (2%). CONCLUSIONS: Fascial pubovaginal sling is an effective treatment for all types of stress incontinence with acceptable long-term efficacy.
Weakened cadaveric fascial sling: an unexpected cause of failure.
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