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Biomedical subjects

J G Chang

Publications and source records attributed to J G Chang.

148 records · Page 9Linked to original sources
PubMed1980

Systemic lupus erythematosus and lymphoma.

2 cases of non-Hodgkin's lymphoma developing in young women with systemic lupus erythematosus (SLE) are described. The interval between the diagnosis of SLE and the development of lymphoma was 4 years and 4 months, respectively. In 1 patient the lymphoma was localised primarily in the lung. It is suggested that the development of lymphadenopathy in a patient with SLE should be an indication for early lymph node biopsy.

Adolescent↗
PubMedDate not supplied

Ras oncogene and p53 gene hotspot mutations in colorectal cancers.

Ras oncogene and p53 gene mutations are frequently observed in colorectal cancers. The role of co-operation between these two genes in the tumorigenesis of colorectal cancer was evaluated. Point mutations in K-ras oncogene and hotspot codons of p53 gene of colorectal cancers were evaluated by naturally created or amplified created restriction site method. Nine of 42 cases (21.4%) of colorectal cancer showed K-ras oncogene mutations. Six of 42 cases (14.3%) of colorectal cancer showed p53 gene hotspot point mutations. The low frequency of p53 gene mutation in this series may be due to racial difference or different hotspot codons. When six cases with mutated p53 gene were examined, only one (16.7%) showed concurrent K-ras oncogene codon 12 and p53 gene codon 248 mutations. We concluded that the co-operation between ras oncogene and p53 gene hotspot point mutations in the tumorigenesis of colorectal cancer in Chinese was not common. Other factors such as adenomatous polyposis coli gene mutations, oncogene activation or tumour suppression gene inactivation may be involved.

Base Sequence↗