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Biomedical subjects

J G Debbie

Publications and source records attributed to J G Debbie.

16 recordsLinked to original sources
PubMed1991

The geographic spread and temporal increase of the Lyme disease epidemic.

OBJECTIVE: To describe the temporal and geographic progression of the Lyme disease epidemic in New York State from 1977 through 1989. DESIGN: Communicable disease surveillance system. SETTING: Statewide. MAIN OUTCOME MEASURES: The progression of the epidemic was examined by analyzing trends in Lyme disease cases reported to the state surveillance system, town and county Lyme disease incidence rates, Lyme disease hospital discharge rates, and the distribution of Ixodes dammini ticks obtained from surveillance efforts and submitted for identification. MAIN RESULTS: The number of confirmed Lyme disease cases in New York has increased with concurrent increases in the number of hospital discharges. The number of counties endemic for Lyme disease increased from four to eight between 1985 and 1989. The number of counties with documented I dammini ticks increased from four in 1985 to 22 in 1989. Incidence of the disease also increased within known endemic counties. CONCLUSIONS: Tick surveillance indicated that the range of I dammini has expanded annually into areas up to 384 km from the original known endemic areas of Long Island, NY, and Connecticut. Cumulative data from human surveillance resources document both temporal increases and geographic expansion of the Lyme disease epidemic in New York.

Adolescent↗
PubMed1987

A community hospital outbreak of legionellosis. Transmission by potable hot water.

Seven cases of nosocomial legionellosis occurred between February and September 1982 in a small community hospital in Upstate New York. All seven were cases of Legionella pneumophila serogroup 1; six were hospital patients and one a hospital employee. None of the cases died. During the peak of the outbreak, the incidence of nosocomial legionellosis was 1.2 cases per 100 patient discharges. An epidemiologic comparison of the six patient cases with 21 matched patient controls suggested that longer hospital stay (chi 1(2) = 24.2, p less than 0.001) and the proximity of patients' rooms to ward showers (chi 1(2) = 4.4, p less than 0.04) were significant risk factors for acquiring legionellosis. An environmental investigation demonstrated that the ward showers and the hospital hot water system were contaminated with L. pneumophila serogroup 1. Monoclonal antibody subtyping performed on isolates obtained during the outbreak investigation confirmed that the hot water system and patient isolates had an identical pattern of reactivity. The outbreak demonstrates that legionellosis can be a significant cause of nosocomial pneumonia in a community hospital and that transmission can occur from contaminated potable hot water sources, potentially via shower aerosols.

Aged↗
PubMed1975

Some hematological values of free-ranging African elephants.

Blood samples were collected from 23 free-ranging African elephants(Loxodonta africana) in Tanzania. Red and white blood cell counts, white blood cell differential, hemoglobin, blood copper, and blood inorganic phosphate were determined. No correlation of any of these measurements with age and sex was discernible, except that the total white count was significantly higher in females than in males in all age groups. The findings are compared with those previously reported for captive and free-ranging African elephants.

Animals↗
PubMed1974

Use of inoculated eggs as a vehicle for the oral rabies vaccination of red foxes (Vulpes fulva).

The ERA vaccine strain of rabies virus propagated on continuous porcine kidney tissue culture cells (PK15) was inoculated into the yolk sac of embryonated chicken eggs for the purpose of oral vaccine distribution. Two inoculated eggs were subsequently fed to each of 12 serologically rabies-negative foxes. Six (50%) of the foxes developed demonstrable rabies serum-neutralizing antibody within 4 weeks of vaccination and resisted challenge to street virus 14 weeks postvaccination. Testing of inoculated eggs for virus stability in the presence and absence of a casein hydrolysate-sucrose stabilizer at 6, 22, and 37 C for up to 15 days revealed no advantage to the stabilizer-vaccine mixture in eggs.

Administration, Oral↗
PubMed1974

Rabies.

Explore the source record for details and available documents.

Animals↗
PubMed1972

Standardization and quantitation of immunofluorescence in the rabies fluorescent-antibody test.

The standardization and quantitation of immunofluorescence with a Farrand microphotometer in the rabies fluorescent-antibody technique were determined. The system is useful in maintaining the quality of examinations for rabies in a public health laboratory since quantitation of reagent, equipment performance, and specificity of reaction can be evaluated. An analysis of the results demonstrates the high degree of reproducibility and the accuracy of the techniques described.

Animals↗
PubMed1972

Rabies antibody determination by immunofluorescence in tissue culture.

A tissue culture (TC)-fluorescent antibody (FA) technique for the measurement of rabies-neutralizing antibody was found to be reliable and comparable to the standard mouse serum neutralization test. This test was performed with BHK-21 cells infected with the ERA vaccine virus strain on Lab-Tek TC chamber slides. A Flury high egg passage (HEP) rabies virus strain grown on continuous line of African green monkey (Vero) and on BHK-21 cells was investigated to determine its utilization in a TC-FA neutralization procedure. Although both the HEP and ERA viruses infected Vero and BHK-21 cells, the amount of fluorescent antigen observed was most consistent with ERA virus and BHK-21 cells.

Animals↗
PubMedDate not supplied

Public health aspects of current oral rabies vaccines.

The use of a live oral rabies vaccine for the immunization of foxes is an accomplished fact. An oral rabies vaccine for field use has been developed, with care taken to ensure that the vaccine virus will not become established in nature. Education has been a major component of oral rabies vaccination campaigns.

Animals↗