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Biomedical subjects

J G Gutierrez

Publications and source records attributed to J G Gutierrez.

6 recordsLinked to original sources
PubMed1986

A multipurpose overtube for diagnostic and therapeutic flexible fiberoptic endoscopy.

A newly devised overtube for diagnostic and interventional endoscopy has been used in 140 cases. In 60 cases of acute gastrointestinal bleeding, adequate gastric lavage was completed in 14.1 +/- 1.3 min, using an average of 7.5 +/- 0.69 liters; the volume of fluid recovered was 103.9 +/- 0.58% of the volume infused. This tube also allows simultaneous gastric lavage and esophageal or gastric tamponade, enabling therapeutic intervention with sclerotherapy or bipolar coagulation in the patient with acute massive bleeding. This device can be employed for the removal of bezoars, foreign bodies, and multiple polyps.

Adolescent↗
PubMed1980

Reflux esophagitis: effect of oral bethanechol on symptoms and endoscopic findings.

We ascertained the effectiveness of oral bethanechol on symptoms and endoscopic evaluation of reflux esophagitis in a double-blind controlled study. Forty-four patients were treated with either 25-mg bethanechol tablets or placebo, each given four times daily for 4 weeks, in addition to conventional medical therapy. Both therapies significantly decreased symptoms as well as endoscopic lesions; however, endoscopic improvement was significantly better in the bethanechol-treated group. Bethanechol therapy resulted in complete endoscopic healing in 10 of 22 cases, whereas only three of 22 patients in the control group had such healing. No worsening of endoscopic lesions was seen in either group. Our study indicates that bethanechol is an effective drug offering advantages over conventional antacid therapy in the treatment of reflux esophagitis.

Administration, Oral↗
PubMed1978

Methyldopa-induced pancreatitis.

An acute febrile illness associated with gastrointestinal upset developed in a patient within one week after starting treatment with methyldopa. The illness was characterized by prompt subsidence of symptoms when the patient withdrew therapy secondary to gastrointestinal upset, and recrudescence of symptoms when methyldopa therapy was reinitiated. This was associated with hyperamylasemia, hyperlipasemia, hyperpyrexia, and epigastric pain, both on admission to the hospital and upon rechallenge with methyldopa. Although gastrointestinal upset has been reported as an untoward side effect of methyldopa, this is the first report to our knowledge of documented methyldopa-induced hyperamylasemia and hyperlipasemia secondary to pancreatitis.

Amylases↗
PubMed1977

Effect of motilin on the lower esophageal sphincter of the opossum.

We have studied the effect of Yajima's synthetic motilin on the lower esophageal sphincter (LES) of the opossum and compared its potency to that of gastrin and its interaction with secretin. Dose-response curves for the LES were constructed from the intravenous bolus injection of graded doses of motilin and gastrin alone and motilin given against a background infusion of secretin. The smallest dose of motilin that elicited a significant response was 0.05 microng/kg, and the highest response was observed with the highest dose used in this study (1.0 microng/kg). Over a wide dose range, both motilin and gastrin were found to be equally potent in stimulating the LES of the opposum, and secretin caused inhibition of the LES pressure to motilin. Therefore, we conclude that (1) motilin is a potent stimulant of the LES; (2) this response is dose dependent; (3) motilin's potency is similar to that of gastrin; and (4) secretin counteracts the effect of motilin on the LES.

Animals↗