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Biomedical subjects

J G Ljunggren

Publications and source records attributed to J G Ljunggren.

At least 55 records · Page 3Linked to original sources
PubMed1978

The effect of propranolol on serum levels of T4, T3 and reverse-T3 in hyperthyroidism.

The effect of propranolol (40 mg t.d.s.) on the peripheral levels of T4, T3 and reverse-T3 was studied in 26 patients with hyperthyroidism. The compounds were measured by specific radioimmunoassay techniques. The levels were followed for five weeks and compared with the levels before treatment. The results show that propranolol had no significant effect on the peripheral levels of T4 despite a rapid amelioration of clinical symptoms. A significant reduction of T3 levels was obtained during the first to fourth week of treatment. No significant decrease was obtained after the fourth week. A significant elevation in reverse-T3 levels was obtained during the second to fourth week of treatment. No significant change was obtained either during the first week or after the fourth week. Inconsistent fluctuations in hormone levels, both before and during treatment, could be seen in individual cases. The results suggest that the reduction of clinical symptoms must be caused by an extrathyroidal action of propranolol which does not seem to involve the pituitary gland.

Adult↗
PubMed1978

Radioimmunoassay of triiodothyronine and thyroxine in capillary blood.

A radioimmunoassay technique for the estimation of T3 and T4 levels in capillary blood is described and evaluated in comparison to a simultaneously drawn and equally analyzed sample from the cubital vein. A total number of 236 samples thus received from the capillary and the vein from euthyroid, hypo- and hyper-thyroid patients were collected. For both T3 and T4 a good correlation (r = 0.94) was obtained. The clinical implication would especially be for paediatric practice.

Capillaries↗
PubMed1977

Comparison between serum thyroxine and triiodothyronine estimation and the TRH test in the routine diagnosis of hyperthyroidism.

Serum T3 and T4 levels have been determined by a radioimmunoassay technique and the TRH test has been performed in 50 patients in whom hyperthyroidism could not be ruled out by the first clinical examination alone. Each patient was then further evaluated in order to establish the state of the thyroid function. The extent to which the determination of T3 or T4 could replace the TRH test in the routine diagnosis of hyperthyroisism was evaluated. The results showed that 26 of the 50 patients had normal thyroid function and 24 had hyperthyroidism. No patient in the normal groups and all but one in the hyperthyroid group had T3 levels above the upper normal limit (2 S.D.). Two of the patients in the normal group and 19 in the hyperthyroid group had T4 levels above the upper normal limit (2 S.D.). Twenty of the patients in the normal group showed a normal TSH response to TRH (increment is greater than 3.0 micronU/ml); the remaining 6 showed an impaired or absent response. Twenty of the hyperthyroid patients had no response and four had a slightly positive response to TRH. No hyperthyroid patient had a TSH response exceeding 3.0 micronU/ml. It is concluded that the determination of T3 is superior to both the determination of T4 and the TRH test for the laboratory discrimination between eu- and hyperthyroidism.

Adult↗
PubMed1977

The effect of body temperature on thyroid hormone levels in patients with non-thyroidal illness.

During studies on the mechanism underlying the low serum T3 levels in euthyroid patients with various acute and chronic non-thyroidal illnesses, it became evident that body temperature may be one parameter associated with changes in serum T3 levels. Forty-nine hospitalized, euthyroid patients with hyperpyrexia caused by various non-thyroidal illnesses were studied. The levels of serum T3 were found to decrease gradually with increasing body temperature. T3 was already below the normal level +/- 2 S.D. at a body temperature of around 38 degrees C. Such low T3 levels as were seen at temperatures of above 40 degrees C are observed in thyroid patients only during severe hypothyroidism. The levels of T4 and TSH remained unchanged and within the normal range regardless of body temperature. The levels of reverse-T3 in the sera analyzed were found to be unchanged in some cases, while in others they paralleled body temperature. It is concluded that the body temperature must be taken into consideration when studying the serum levels of T3.

Adolescent↗
PubMed1976

Radioimmunoassay of triiodothyronine in human serum with special reference to methodological problems.

A radioimmunoassay for measuring the level of triiodothyronine in human serum has been developed and studied with respect to interference from hormone-binding substances present in human serum. Dextran-coated charcoal was used for the separation of free and antibody-bound hormone. ANS (8-anilino-1-naphthalenesulfonic acid) was used to reduce the interference from hormone-binding substances in serum. Extraction of the hormone by ethanol before the radioimmunoassay did not solve the problem of interference, even in the presence of an internal standard. The protein concentration in the assay system strongly influenced the charcoal adsorption of free and antibody-bound hormone, and optimal concentrations for both proteins and ANS had to be worked out to get a reliable assay for unextracted serum.

Anilino Naphthalenesulfonates↗
PubMed1976

Rapid simultaneous radioimmunoassay for the measurement of triiodothyronine and thyroxine in unextracted human serum.

A rapid simultaneous radioimmunoassay for the measurement of triiodothyronine and thyroxine in unextracted human serum is described. The method requires 25 mul serum. Approximately 150 human sera can be tested for triiodothyronine and thyroxine levels in one day by one technical assistant. The triiodothyronine levels in peripheral venous blood in euthyroid subjects and in patients with various thyroid diseases are as follows: euthyroid (50) 115 +/- 22 (mean +/- SD) ng/100 ml, hypothyroid (20) 33 +/- 35 (mean +/- SD) ng/100 ml and hyperthyroid (20) 411 +/- 142 (mean +/- SD) ng/100 ml. The corresponding levels for thyroxine are: 6.9 +/- 1.3, 2.0 +/- 1.4 and 21.4 +/- 5.2 mug/100 ml. The levels of triiodothyronine in the thyroid venous blood are higher (P less than 0.05) than in the peripheral venous blood. The levels of thyroxine in the thyroid venous blood was not significantly higher than in peripheral venous blood.

Binding Sites, Antibody↗
PubMed1976

Concentration of thyroxine, tri-iodothyronine and thyroglobulin in the thyroid lymph.

Human thyroid lymphatic fluid was collected from 8 patients operated upon for thyroid tumours. All tumours were of small size and localized to one lobe. The lymph was collected from the side opposite the tumour. The levels of thyroxine and tri-iodothyronine in the lymph were determined by a radioimmunoassay technique in 7 of the patients. The thyroglobulin content of thyroidal lymph from one patient was analysed. The results demonstrate higher levels of thyroxine and tri-iodothyronine in the human thyroid lymphatic fluid as compared with those seen in peripheral or thyroid venous blood. Evidence for the presence of thyroglobulin in the human thyroid lymphatic fluid was obtained.

Adult↗
PubMed1975

Subcutaneous administration of sodium l-thyroxine to patients with hypothyroidism.

Two patients with primary hypothyroidism are described in whom an euthyroid condition could not be achieved by oral administration of 1-thyroxine, 1-triiodothyronine or desiccated thyroid. Daily subcutaneous injections of 1-thyroxine normalized the thyroxine and triiodothyronine levels in the blood and the patients became euthyroid.

Aged↗
PubMed1975

Preoperative treatment of thyrotoxicosis with a beta-adrenergic blocking agent.

The clinical usefulness of propranolol as the sole drug in the preoperative treatment of thyrotoxicosis has been investigated. The effect of the drug on the serum levels of thyroxine and triiodothyronine has also been studied. Eight consecutive patients were treated. Four of these showed good clinical response to propranolol and both pre- and postoperative periods were uneventful. Two patients also showed a good clinical response but developed accentuated thyrotoxic symptoms in the immediate postoperative period. One patient showed no clinical response to propranolol therapy and in one further patient the treatment was discontinued because of discomfort. All glands were resected without technical difficulty. They were more vascular and friable after this therapy than after pretreatment with antithyroid drugs and thyroxine. The serum levels of thyroxine and triiodothyronine decreased during propranolol treatment. It is concluded that treatment with propranolol as a sole preoperative drug might be used as an alternative only in cases where conventional therapy is not suitable.

Adrenergic beta-Antagonists↗